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What are the two anatomical subdivisons of the nervous system?
- Central nervous system
- Peripheral nervous system
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What body cavity does the CNS belong to?
Dorsal body cavity
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What is the function of the CNS?
- Integration, processing,
- Interperts incoming sensory information
- Directs motor responses (both visceral
- & organs)
- Seat of higher functions
- Intelligence, memory, learning
- Emotion
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In early developement how does the CNS begin?
As a mass of neural tissue organizing into hollow tubes
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What is the PNS?
All neural tissue outside the CNS
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What is the funciton of the PNS?
- Communication link with the CNS
- Provides sensory input
- Carries motor output
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How does the PNS create a link with the CNS?
Nerves extend to/from brain & spinal cord
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In the PNS where do the cranial nerves connect?
To & from brain
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In the PNS where do the spinal nerves connect?
To & from the spinal cord
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What are the two different types of cranial and spinal nerve fibers?
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Afferent and Efferent are what type of anatomical division?
Functional divisons
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Where does the afferent division of the PNS begin?
Begins at receptors
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Where does the efferent division of the PNS begin?
Begins inside the CNS
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What does afferent mean?
Toward
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What does efferent mean?
Exiting
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What is the function of the afferent nerve fiber?
Brings information to the CNS
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What is the function of the efferent nerve fiber?
Carry motor commands from the CNS to the body
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What type of nerve fibers are afferent?
Sensory nerves
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What type of nerve fibers are efferent?
Motor nerves
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Give examples of efferent nerve fibers.
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What are the efferent nerve fibers specialized to do?
Perform specific functions
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Give examples of receptors.
- May be a dendrite, specialized cell or cluster of cells
- Or a complex sense organ
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Name the two components of the afferent and efferent divisions?
Somatic & visceral
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What does the somatic component monitor?
- Skeletal muscles, joints & the skin
- Voluntary of Involuntary
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What does the visceral compontent control?
- Smooth muscle, cardiac muscle, glands
- Ventral body cavity system
- ANS outside awareness of control
- Homeostasis
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What is neural tissue? What are two basic cell types?
- Nervous tissue
- Neurons
- Neuroglia
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What is the function of neural tissue?
- Specialized for the conduction of electrical impluses from one
- Region of the body to another sends signals that are
- Rapid, specific and usually cause immediate response
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What is another name for the perikaryon?
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Describe the characteristics of the cell body?
- Usually has several branching dendrites, is attached to an
- Elongated axon that ends at one or more synaptic terminal
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What is the does the cell body contain?
- Organelles responsible for energy production & biosynthesis
- Of organic molecules such as enzymes
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The nerve cell neuron is highly specialized, what funciton can it perform as a result of this?
Transfer & process information
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What is the function of the neurons?
Transmit the electrical impulse along their cell membrane
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What kind of cell is a neuron (not nerve cell)?
- Excitable cells
- Highly specialized
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What is the longest cell in the body? How long?
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Why do neurons have longevity?
- It cannot divide or repair
- Lacks centrioles and centrosomes
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Name the neuroglial cells of the CNS.
- Astrocytes
- Oligodendrocytes
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What are the functions of neuroglial cells?
- Supporting framework for neural tissue
- Provides nutrients to neurons
- Isolate and protect neurons
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How many neuroglial cells are their?
5 times as many as neurons
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What are the neuroglial cells capable of that the neurons are not?
Can divide and repair
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How many types of glial cells are in the CNS?
4 types
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How many types of glial cells are in the PNS?
2 types
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What makes the neural tissue of the CNS different from the PNS?
Glial cells
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When a stimulus is received it can only move one direction, why?
Because of the chemical synapse
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What are astrocytes known as?
Star cells
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What is the function of the astrocytes?
- Shield neurons from direct contact with other neurons & fluid
- Maintain blood-brain barrier
- Structural repairs
- Absorbs and recycles neurotransmitters
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What is the astrocyte feet?
Process of the astrocyte.
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What is the function of the astrocyte feet?
Contacts the surface & covers most of the surface of capillaries within the CNS
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What significantly increases the suface area of the astrocyte?
A large number of cytoplasmic processes
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How does the increase of surface area of the astrocyte control the interstitial environment?
- By facilitating the exchange of ions and
- Other molecules within the extracellular fluid
- Within the CNS
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What is the frame work of astrocytes?
Packed with microfilaments that extend across the breadth of the cell.
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How does the astrocyte support the brain & spinal cord?
By forming a structural framework
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What is essential for maintaining the blood-brain barrier?
Chemical secretions of the astrocyte
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What are neurotropic factors?
- Secreted astrocyte chemicals involved in directing growth &
- Interconnection of developing neurons
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What is the function of the oligodendrocytes?
Myelinate CNS axons
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How does myelin improve the functional performance of neurons?
Myelin helps prevent the electrical current from leaving the axon
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Define internodes?
Large area wrapped in myelin
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What are nodes of ravier? How are they produced?
- Gaps between the myelin sheaths
- Produced by adjacent oligodendrocytes
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What is another name for myelin sheaths?
Nodes of Ravier
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What is the area called white matter? Why does it appear white?
- Regions dominated by myelinated axons of the CNS
- Lipids
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What is the area of gray matter? What makes it gray?
- Regions dominated by neuron cell bodies, dendrites, & unmyelinated axons
- Ribosomes
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What are the microglia in the CNS?
Phagocytic cells
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In times of infection or injury what glial cells increase dramatically in the CNS?
Microglial
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Describe microglial cells?
Smallest glial cells, posess slender cytoplasmic processes with many fine branches
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How are microglial cells developed?
Appear early in embroynic development through the division of mesodermal stem cells
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Describe ependymal cells?
- Cubodial to columnar in form. Unlike typical epithelial cell axon
- They have a slender process that branch extensively, making direct
- Contact with glial cells in surrounding neural tissue
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What is the ependyma?
A thin epithelial membrane(made up of ependymal cells) that lines ventricles or the brain, central canal of the spinal cord. A type of neuroglial
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What do the ciliated ependymal cells assist with?
Circulation of the cerebrospinal fluid
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What do the ependymal cells secrete?
Cerebrospinal fluid
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Where is the neuroglial of the PNS appear?
Outside brian and spinal cord
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What is a collection of nerve bodies in the PNS?
Ganglia
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Where are satellite cells located?
They surround neuron cell bodies within ganglia
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What is the function of satellite cells?
- Insulate the neuron from other stimuli
- Regulate the exchange of nutrients & wastes with extracellular fluid
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Every cell in the PNS is covered by what?
Schwann cell
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What does the schwann cell aid in?
Regrowth of damaged axons
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What is the neurolemma?
The superficial cytoplasmic covering of schwann cells
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What does the perikaryon contain?
- Organelles that provide energy and perform biosynthetic activities.
- Neurons, mitochondria, free & fixed ribosomes & membranes of the
- Rough endoplasmic reticulum
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Where does the nerve impulse begin?
The axon hillock
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What do neurons lack?
Centrioles
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Because the neuron lack centrioles what does that result in?
An inability to divide
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What are neurofibrils?
Bundles of neurofilaments. Cytoskeleton elements that extend into the dendrites and axon
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What does the cytoskeleton of the perikaryon contain?
Neurofilaments & neurotubules
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What are nissl bodies?
Ribosomal clusters
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What is another name for nissl bodies?
Chromatophilic substance
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How is the action potential generated?
- At the axon when it is exposed to appropiate stimuli, producing a localized change in the
- Transmembrane potential
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What is the transmembrane potential?
A property resulting from the equal distribution of ions across the neurilemma
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Define axon?
A long cytoplasmic process capable of propagating an action potential
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Where is the axon hillock?
A special region in the multipolar neuron that connects the initial segments of the axon to the soma
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What is the axoplasm?
Cytoplasm of the axon
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What does the axoplasm contain?
- Neurofibrils, neurotubules, numerous small vesicles, lysosomes, mitochondria and various
- Enzymes
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What is the side branching of an axon called?
Collaterals
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What are the terminal arborizations?
- The main trunk & the collateral end
- In a series of fine terminal extentions
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Where does the terminal arborization end?
At the synaptic terminal
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What is the synaptic terminal?
- Where the neuron contacts another neuron or effector
- Part of the synapse
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Describe axoplasmic transport?
Movement of organelles, nutrients, synthesized molecules & waste products between the cell body and synaptic terminals. Complex process. Consumes energy & relies on movement along the neurofibrils of the axon and it's branches
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What is the synapse?
Specialized site where the neuron comminicates with another cell
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Where is the terminal bouton found?
Where one neuron synapses on another
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What is another name for the terminal bouton?
Synaptic knob
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What is the function of the glial cells?
To limit the number & type of stimuli
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Name the four structural classifications of neurons?
- Anaxonic
- Bipolar
- Pseudounipolar
- Multipolar
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What are anaxonic? Where are they found?
- Small, cannot distinguish from dendrites
- Only found in CNS and in special sense organs
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What does bipolar neurons contain?
A number of fine dendrites that fuse to form a single dendrite. Cell body lies between this dendrite & a single axon. Relatively rare
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What important role do bipolar neurons play? Are their axons myelinated?
- Relaying sensory information concerning sight, smell, & hearing
- Axons are not myelinated
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What does the pseudounipolar look like? Is it myelinated? What type of neurons are these?
- Continious dendrite & axonal processes & cell body lies off to one side. The initial segment lies at the base of the dendrite branches. May be myelinated
- Usually sensory neurons
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What is the most common neuron in the CNS?
Multipolar
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Describe a multipolar neuron?
All motor neurons that control skeletal muscles. Myelinated axons. Several dendrites & a single axon that may have one or more branches.
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What are pre-ganglionic fibers?
Axons extending from the CNS to a ganglion
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What are post ganglionic fibers?
Axons connecting the ganglion cells with the peripheral effectors
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What are afferent fibers? Where are they found?
Axons of sensory neurons. Extend between sensory receptor and the spinal cord or brain
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Name the three catagories of receptors.
- Exteroceptors
- Proprioceptors
- Interoceptors
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Name the three functional classifications of neurons. Which system do they belong to?
- Sensory (PNS)
- Interneurons (CNS)
- Motor (PNS)
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What is the function of the sensory neurons?
Transmits impulses from sensory receptors to CNS using afferent fibers
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What forms the two afferent divisions of the PNS?
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What does the somatic division of the PNS deliver?
- Information about the outside world and our position in it
- Consciously controlled
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What organs belong in the somatic division?
Muscles, joints, skin, sense organs
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What does the visceral division of the PNS deliver?
Information on internal conditions & status of other organs
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What organs belong to the visceral division of the PNS?
Smooth muscle, cardiac muscle, organs, glands
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What is the function of interneurons? Where are they located?
- Analysis of sensory inputs & coordination or motor outputs
- Within the CNS
- May be between the sensory & motor neurons
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What neurons account for 99% of the body?
Interneurons
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Most interneurons are structurally what type of neuron?
Multipolar
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Finish this sentence, the more complex the given stimulus...
The greater the number of interneurons involved
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What is the function of motor neurons?
Carry impulses away from the CNS to stimulate or modify the activity of a peripheral tissue or organ
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What type of fibers are the motor neurons?
Efferent fibers
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What is the efferent somatic division (SNS) responsible for?
Innervate skeletal muscles consciously controlled
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What is the efferent visceral division responsible for?
- Autonomic(ANS)
- Effects organs, tissues, other muscles
- Little conscious control
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What two properties of an axon determines the rate of impluse conduction?
- The presences or absence of a myelin sheath
- The diameter of the axon
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What results in a change in the resting membrance potential?
Ion movement
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How does the action potential develope?
After the plasmalemma is stimulated to a level known as threshold. Once threshold has been reached, the membrane permability to sodium & potassium ions changes
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Define excitiability.
Ability of cell membrane (plasmalemma) to conduct electrical impulses
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Define nerve impulse.
Propagation of action potentials
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What is a vesicular synapses?
Chemical synapse
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All somatic neuromuscular synapses utilize what?
Ach
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What is the synaptic communication?
Neuroeffector junction where axon interacts with another neuron, muscle or gland
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What is the process of chemical synapses?
- Action potential arrives at end of presynaptic axon
- Synaptic vesicles release neurotransmitter
- Neurotransmitter diffuses across synaptic cleft
- Neurotransmitters bind to postsynaptic membrane receptors
- Effects channels in postsynaptic membrane (close or open)
- Result=stimulation or inhibition
- Neurotransmitters are broken down by enzymes or transported back into presynaptic terminal.
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What is present in the electrical synapses?(non-vesicular)
Gap junctions between the CNS & PNS neurons
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In chemical synapses communication is which direction?
Only one way from presynaptic to postsynaptic
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In electrical synapses communication is which direction?
Can convey nerve impulses in either direction
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What are neuronal pools?
- Organized interneurons into smaller numbers
- Group of neurons with specific functions
- Defined by function soley
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How many neurotransmitters are their?
Over 50
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