Author:
tswhite
ID:
76767
Filename:
Study Guide Chapters 8,9 Pharmacology
Updated:
2011-04-02 19:07:16
Tags:
Xanthines Mucus controlling drug therapy
Folders:

Description:
Part 2 of 3 for Test for Chapters 6-11
Show Answers:

Study Guide Chapters 8,9 Pharmacology

  1. The mechanism of action by xanthines is:
    A. unclear
    B. not published
    C. understood by a few physicians but not public knowledge
    D. well defined
    A. unclear
    (this multiple choice question has been scrambled)
  2. Theophylline has been used to treat all of the following except:
    A. COPD
    B. apnea of prematurity
    C. pneumonia
    D. asthma
    C. pneumonia
    (this multiple choice question has been scrambled)
  3. The xanthine of choice to treat apnea of prematurity is:
    A. aminopylline
    B. caffeine citrate
    C. dyphylline
    D. theophylline
    B. caffeine citrate
    (this multiple choice question has been scrambled)
  4. Theophylline and caffeine are examples of:
    A. anticholinergics
    B. corticosteroids
    C. methylxanthines
    D. B agonists
    C. methylxanthines
    (this multiple choice question has been scrambled)
  5. Theophylline is classified as a bronchodilator because it:
    A. has a relaxing effect on bronchial smooth muscle
    B. blocks cholinergic sites
    C. stimutaes alpha-adrenergic sites
    D. stimulates B2-adrenergic sites
    A. has a relaxing effect on bronchial smooth muscle
    (this multiple choice question has been scrambled)
  6. Xanthines have all the following physiological effects except:
    A. CNS stimulation
    B. bronchial smooth muscle relaxation
    C. cardiac muscle stimulation
    D. cerebral vasodilation
    D. cerebral vasodilation
    (this multiple choice question has been scrambled)
  7. Which drug stimulates skeletal muscle and the CNS most strongly?
    A. ipratropium
    B. caffeine
    C. aminophylline
    D. theophylline
    B. caffeine
    (this multiple choice question has been scrambled)
  8. An incr in intracellular cyclic adenosine 3',5'-monophosphate (cAMP) causes:
    A. cardiac muscle relaxation
    B. skeletal muscle contrxn
    C. bronchial smooth muscle relaxation
    D. bronchial smooth muscle contrxn
    C. bronchial smooth muscle relaxation
    (this multiple choice question has been scrambled)
  9. It is difficult to determine therapeutic doses of theophylline because:
    A. xanthines do not interact with other medications
    B. all doses of theophylline and its derivatives are equivalent
    C. individuals may be allergic to theophylline
    D. individuals metabolize theophylline at different rates
    D. individuals metabolize theophylline at different rates
    (this multiple choice question has been scrambled)
  10. The currently recommended blood serum theophylline level for the management of asthma is:
    A. 20 to 25 micrograms/ml
    B. 10 to 20 micrograms/ml
    C. 5 to 15 micrograms/ml
    D. <5 micrograms/ml
    C. 5 to 15 micrograms/ml
    (this multiple choice question has been scrambled)
  11. The recommended therapeutic blood serum range of theophylline for use in the treatment of COPD is:
    A. >20
    B. 12 to 20
    C. 10 to 12
    D. 5 to 10 micrograms/ml
    C. 10 to 12
    (this multiple choice question has been scrambled)
  12. Dosage of theophylline is best monitored by:
    A. measurement of serum drug levels
    B. monitoring for adverse drug effects
    C. measuring urine drug levels
    D. clinical reaction of the patient
    A. measurement of serum drug levels
    (this multiple choice question has been scrambled)
  13. Theophylline blood levels can be increased by all of the following except:
    A. pneumonia
    B. corticosteroids
    C. B agonists
    b. B blockers
    C. B agonists
    (this multiple choice question has been scrambled)
  14. Common, less toxic side effects of theopylline therapy include which of the following?
    I. h/a
    II. gastric upset
    III. anxiety
    IV. nervousness
    V. diuresis

    A. I, II, III, IV, and V
    B. I, II, III, and V
    C. II, IV, and V
    D. I and II
    A. I, II, III, IV, and V
    (this multiple choice question has been scrambled)
  15. A decr in blood theophylline levels could be caused by all of the following except:
    A. cigarette smoking
    B. B Agonists
    C. IV isoproterenol
    D. renal failure
    D. renal failure
    (this multiple choice question has been scrambled)
  16. Disadvantages of theophylline therapy include which of the following:
    I. narrow therapeutic margin
    II. toxic effects
    III. unpredictable blood levels
    IV. need for individual dosing
    V. numerous drug-drug and drug-condition interactions
    all (five) of the above
  17. Nonbronchodilating effects of theophylline include all the following except:
    A. incr ventilator drive
    B. incr pulmonary vascular resistance
    C. incr respiratory muscle strength and endurance
    D. antiinflammatory effects
    B. incr pulmonary vascular resistance
    (this multiple choice question has been scrambled)
  18. You are working the night shift when a 68-year-old COPD patient is admitted through the ER. He has been given combivent and inhaled corticosteroids. The intern on call asks your recommendation for additional medication to give the patient. You would recommend:
    A. theophylline
    B. albuterol
    C. levalbuterol
    D. formoterol
    A. theophylline
    (this multiple choice question has been scrambled)
  19. A significant side effect of theophylline often seen in patients is:
    A. nausea
    B. hypertension
    C. bradycardia
    D. drowsiness
    A. nausea
    (this multiple choice question has been scrambled)
  20. The therapeutic range for theophylline is:
    A. 20 to 30
    B. 10 to 20
    C. 5 to 10
    D. <5 micrograms/ml
    B. 10 to 20
    (this multiple choice question has been scrambled)
  21. There are many possible explanations of how theophylline works. All of the following are possible theories except:
    A. inhibits phosphodiesterase
    B. blocks adenosine
    C. blocks acetylcholine
    c. produces catecholamines
    C. blocks acetylcholine
    (this multiple choice question has been scrambled)
  22. Which of the following is not a function of mucus in the body?
    A. protection from inflammation
    B. waterproofing
    C. improvement of gas exchange
    D. lubriation
    C. improvement of gas exchange
    (this multiple choice question has been scrambled)
  23. Diseases with hypersecretion or poor clearance of secretions include which of the following?
    I. cystic fibrosis
    II. pneumonia
    III. CHF
    IV. primary ciliary dyskinesia

    A. I, II, and IV only
    B. II and III only
    C. I and II only
    D. I only
    A. I, II, and IV only
    (this multiple choice question has been scrambled)
  24. Medications that incr mucociliary or cough efficiency are:
    A. expectorants
    B. mucoregulatory agents
    C. mucolytics
    D. mucokinetics
    D. mucokinetics
    (this multiple choice question has been scrambled)
  25. The number of goblet cells per square mm of normal airway mucosa is:
    A. 60,000
    B. 6000
    C. 600
    D. 60
    B. 6000
    (this multiple choice question has been scrambled)
  26. What structure is responsible for providing the majority of mucus secretions?
    A. submucosal glands
    B. cilia
    C. goblet cells
    D. surface epithelial cells
    A. submucosal glands
    (this multiple choice question has been scrambled)
  27. In peripheral airways the rate of mucociliary transport in the normal peripheral aiway is approx:
    A. 21.5 mm/min
    B. 5.0 mm/min
    C. 1.5 mm/min
    D. 0.5 mm/min
    C. 1.5 mm/min
    (this multiple choice question has been scrambled)
  28. The cholinergic (sympathetic) response in terms of mucociliary clearance is:
    I. incr ciliary beat
    II. decr ciliary beat
    III. incr mucus production
    IV. decr mucus production

    A. II and IV only
    B. I and III only
    C. II only
    D. I only
    B. I and III only
    (this multiple choice question has been scrambled)
  29. Antibaccterial defense in the airway is provided by which of the following?
    I. IgA
    II. IgG
    III. Phospholipids
    IV. Serine proteases

    A. I, II, and IV only
    B. I, II, and III only
    C. III and IV only
    D. I and II only
    A. I, II, and IV only
    (this multiple choice question has been scrambled)
  30. What mucus color indicates retainedf secretions and neutrophil activation?
    A. green
    B. brown
    C. yellow
    D. white
    A. green
    (this multiple choice question has been scrambled)
  31. The physical properties of mucus include which of the following?
    I. adhesion
    II. cohesion
    III. elasticity
    IV. viscosity

    A. I, II, III, and IV
    B. I, II, and III only
    C. I and II only
    D. I only
    A. I, II, III, and IV
    (this multiple choice question has been scrambled)
  32. Which of the following agents is/are currently approved for administration as an aerosolized mucoactive agent?
    I. dry powder mannitol
    II. N-acetylcysteine (NAC)
    III. dornase alfa
    IV. ipratropium bromide

    A. IV only
    B. II only
    C. II and III only
    D. I and II only
    C. II and III only
    (this multiple choice question has been scrambled)
  33. All of the following are hazards associated with the use of acetylcysteine except:
    A. bronchospasm
    B. tachycardia
    C. rhinorrhea
    D. nausea
    B. tachycardia
    (this multiple choice question has been scrambled)
  34. Pulmozyme is the trade name for the mucoactive agent:
    A. iodopropylidene glycerol
    B. mucosil-20
    C. acetylcysteine
    D. dornase alfa
    D. dornase alfa
    (this multiple choice question has been scrambled)
  35. The standard dose of dornase alfa for aerosolization is:
    A. 10 mg in 2.5 ml of diluent
    B. 5.0 mg in 2.5 of diluent
    C. 2.5 mg in 2.5 m. of diluent
    D. 1.0 mg in 2.5 ml of diluent
    C. 2.5 mg in 2.5 m. of diluent
    (this multiple choice question has been scrambled)
  36. Agents that incr volume or hydration of airway secretions are called:
    A. expectorants
    B. bronchodilators
    C. mucolytics
    D. mucoregulatory
    A. expectorants
    (this multiple choice question has been scrambled)
  37. The expectoranct that may stimulate the cholinergic pathway to incr mucus secretion is:
    A. mannitol
    B. SSKI
    C. sodium bicarbonate
    D. guaifenesin
    D. guaifenesin
    (this multiple choice question has been scrambled)
  38. You have a patient with COPD who is struggling to expel viscid mucus plugs. What would you recommend for this problem?
    A. albutrol
    B. cromolyn sodium
    C. acetylcysteine
    D. dopamine
    C. acetylcysteine
    (this multiple choice question has been scrambled)
  39. A resident orders 4 cc of 20% mucomyst aerosolized for an asthma patient. You are called by the unit secretary about te order. You would:
    A. call the resident and obtain a verbal order to give a B2 agonist with the mucomyst
    B. do not admnister the treatment at all
    C. find a student and have them give the treatment
    D. verify the order in the chart and administer as written
    A. call the resident and obtain a verbal order to give a B2 agonist with the mucomyst
    (this multiple choice question has been scrambled)
  40. All the following nebulizers have been tested and approved for use with dornase alfa except:
    A. Acorn II
    B. Hudson RCI Updraft II OPTI-NEB
    C. Misty-Neb
    D. Pari LC Plus
    C. Misty-Neb
    (this multiple choice question has been scrambled)
  41. Acetylcysteine is incompatible in solution with which of the following:
    A. saline
    B. anticholinergic bronchodilators
    C. sympathommetic bronchodilators
    D. certain antibiotics
    D. certain antibiotics
    (this multiple choice question has been scrambled)
  42. How does dornase alfa work?
    A. incr mucociliary beat frequency
    B. breaks down DNA content in sputum
    C. substitutes sulfhydryl radicals for disulfide bonds in mucus
    D. adds water to secretions
    B. breaks down DNA content in sputum
    (this multiple choice question has been scrambled)
  43. How does acetylcysteine (mucomyst) work?
    A. incr mucociliary beat frequency
    B. breaks down DNA content in sputus
    C. substitutes sulhydryl radicals for disulfide bonds to mucus
    D. adds water content to respiratory secretions
    C. substitutes sulhydryl radicals for disulfide bonds to mucus
    (this multiple choice question has been scrambled)