Common side effect of INH. Peripheral neuritis (numbness, paresthesias, tingling in extremities) How to minimize SE of peripheral neuritis from INH? increase pyridoxine (Vit B-6) intake What s/s should a pt report immediately when taking INH?? yellow eyes or skin (INH is hepatotoxic) What should a pt do to avoid causing a rxn of redness, itching, flushing, sweating, tachycardia, headache or lightneadedness with INH? avoid foods with tyraine (swiss cheese, tuna) What drug colors sweat, tears, urine & feces orange? rifampin (Rifadin) What drug causes optic neuritis (decreases visual acuity & ability to discriminate b/w red & green)? ehtambutol (Myambutol) *report symptoms immediately -(take med with food if GI upset occurs) Why should a pt return to clinic weekly for serum drug-level testing of cycloserine (Seromycin)? WHat is a good level? (TB drug) -monitor for potential neurotoxicity -lower than 30mcg/mL reduce incidence of neurotoxicity What baseline studies need to be completed prior to INH therapy for TB? Liver enzyme levels  -INH can cause hepatic enzymes to increase & can cause hepatitis -monitor during first 3 mos; longer if alcohol abuse or >50yoa Three drugs that cause peripheral neuritis. rifabutin (Mycobutin) ethambutol (Myambutol) INH -all for TB SE of ______ include signs of hepatitis, flu-like syndrome, low neutrophil ct, ocular pain or blurred vision. rifabutin (Mycobutin) _______ is associated with serum concentrations of VANCOMYCIN above 60 to 80 mcg/mL Ototoxicity Signs of hypersensitivity reaction to imipenem-cilastatin (Primaxin). Shortness of breath, mouth and tongue swelling, and generalized itching. Ampicillin should be taken ___________ to ensure adequate absorption. on an empty stomach AE of ampicillin (Principen). Diarrhea  -may represent such conditions as pseudomembranous colitis. Some ________ cause a disulfiram-like reaction when alcohol is consumed. cephalosporins Which assessment should be performed prior to the administration of cefotaxime (Claforan)? Culture and sensitivity testing -to determine the causative organism and the appropriate drug therapy. Similar to PCNs but widely used for gram (-). Cephalosporin This drug presents a risk of an allergic reaction as well as a risk of colitis. Cephalosporin Keflex, Ceclor, Rocephin, Maxiphime - what kind of drugs are these? Cephalosporins (Category 1, 2, 3, 4) Most common ADVERSE rxns with cephalosporins. allergic rxns (same as penicillin) Used to kill staph & strep, not effective against MRSA, usually given IV (or IM). Ancef, Kefzol (Cephalosporins) Broadest spectrum of any class of antibiotic. Carbapenems How are carbapenems administered? PARENTERALLY ONLY Drug that causes RED MAN Syndrome. Vancomycin How is Vancomycin administered & why? SLOW IV infusion (over 60 min) - to avoid red man syndrome What labs would you monitor in a pt receiving vancomycin? BUN & Creatinine (risk of nephrotoxicity; watch peak & trough) Possible AE of vancomycin? Ototoxicity Nephrotoxicity damage to tissues @ site of infusion The "last chance" antibiotic. vancomycin S/S of Red Man Syndrome. flushing hypotension tachycardia RASH on upper body When do you draw peak & trough for vancomycin? peak: 1 hr AFTER administering  trough: 30 min PRIOR to administering Drugs that inhibit cell wall synthesis. Penicillins Cephalosporins Carbapenems Vancomycin Isoniazid Drugs that inhibit bacterial protein synthesis. *Tetracyclines *Aminoglycosides *Macrolides K Tetracyclines are baterio______. static What types of bacteria do tetracyclines cover (in general)? broad spectrum gram (+) and gram (-) aerobic & anaerobic Drug of choice for Rocky Mt spotted fever, typhus, cholera, Lyme disease, H.pylori, chlamydia, & syphillis. Why so few? tetracycline so few b/c resistance A major AE of tetracycline? *PHOTOSENSITIVITY* What should pts avoid who are on tetracyclines? the sun!  (photosensitivity) Regarding meals, when should tetracyclines be taken? on an empty stomach (teaching pt) NO antacids with it! Tetracyclines are primarily admistered via which route? PO Macrolides are bacterio_____. cidal Alternative drug for patients with ALLERGY to PCN. Macrolides Drug of choice for Whooping cough, diphtheria, Legionnaires diseace, streptococci, H. influenza. Macrolides "Z-pac" is what kind of antibiotic? Macrolide (inhibits protein synthesis) Examples of Macrolides. Zithromax Biaxin Macrolides are known to cause ______ and ______. GI irritation liver damage What type of drug is gentimicin (garamycin)? Aminoglycoside (inhibits protein synthesis) AE of amino glycosides and two examples. Ototoxicity Nephrotoxicity Gentimicin, Amikin Labs to monitor for a pt on gentamicin. BUN, creatinine (nephrotoxicity) What would you see in a pt receiving amikin or gentimicin which would be a reason to STOP the med? tinnitus, changes in hearing (signs of ototoxicity, can cause permanent hearing loss) increase in BUN or creatinine, protein in urine (nephrotoxicity) Just like with vancomycin, _____  & ______ are checked with gentimicin & amikin. peak & trough levels Protein synthesis inhibitors that are effective against resistant infections but have significant AE that limit use. Cleocin Lincocin Drugs that inhibit DNA replication. Fluoroquinolones Used to treat UTI, URI, GI, GU skin & soft tissue infections. fluoroquinolones "oxacin" drugs. fluoroquinolones (inhibit DNA replication) Fluoroquinolones are effective against gram ___ organisms. positive (+) AE of fluoroquinolones. GI toxicity cardiotoxicity phototoxicity hepatotoxicity SERIOUS AE of fluoroquinolones. tendon rupture Why would you need to immediately call HCP if taking fluoroquinolones? calf or leg pain (tendon rupture) -more in younger males Drug interaction with fluoroquinolones? **anticoagulants, esp Coumadin theophiline Sulfonamides work on gram _____ organisms. positive (+) AND negative (-) Two examples of sulfanomides. bactrim septra Major AE to sulfanomides. SJS Main route of administration for sulfanomides. PO Why are 3 meds given for TB? decrease risk of resistance Two primary drugs given for TB. INH Rifampin Closely monitor pts taking INH due to risk of ______. hepatotoxicity peripheral neuropathy optic neuritis blood dyscrasias anaphylaxis Vision changes or difficulty seeing is an important thing to report with pts taking ______. INH (for TB) Labs to monitor in pts taking INH for TB. Liver enzymes (hepatotoxicity) If a ______ drug is added to a pt with TB, they may have a resistant form. aminoglycoside Encourage pts to take ______ to decrease risk of peripheral neuropathy while taking INH. vitamin B-6 ____ can interact with tyramine foods. *INH* Nystatin, Amp B, Difulcan - what type of drugs? antifungals Systemic fungal infections are more often seen in what type of pts? pts with immune suppression What is nystatin? prototype for antifungal drugs - often used for superficial infections If giving nystatin with other meds, when do you give it? last, so it stays in the mouth and coats it Two antifungals for systemic infections amphotericin B (Fungizone) fluconazole (Diflucan) Things to monitor in pts taking amphotericin-B. *BUN & Creatinine, UOP (nephrotoxicity) *fluid & electrolytes (kidney damage) *BP, ECG (hypotension, dysrhytmias, cardiac arrest) IV site (phlebitis) *hearing loss, tinnitus (OTOtoxicity) The safer systemic antifungal. Diflucan What is contraindicated for fluconazole (Diflucan)? chronic alcoholism (will cause severe N/V, & increased BP) -hepatotoxicity Fluconazole (Diflucan) causes ______ temporarily but it normally goes away. increased BGL What to monitor in pts taking flucanazole (Diflucan). s/s of hepatotoxicity BGL (esp diabetics) assess for NVD, abdominal pain AE of high levels of chloroquine (Aralen). CNS & cardiovascular toxicity (treats malaria) Prevents metabolism of heme, which then builds to toxic levels within the parasite. chloroquine (Aralen), an anti-malarial drug Med used for antiprotozoal (NOT used to treat malaria). metronidazole (Flagyl) Drug that acts as antiprotozoal and also has antibiotic activity against anaerobic bacteria. metronidazole (Flagyl) What is FLAGYL? antiprotozoal (not for malaria), also antibiotic against anaerobes Drug that produces a metallic taste in mouth. Flagyl (antiprotozoal) What drug does metronidazole (Flagyl) interact with? *Coumadin (increased bleeding)* What happens when a pt taking metronidazole (Flagyl) drinks alcohol? disulfram rxn (severe vomiting & GI distress) What labs to monitor in pts taking chloroquine (Aralen)? Hgb, Hct, CBC (bone marrow suppression, can potentiate anemia) _______ will be one of the first signs  associated with renal damage secondary to amikacin toxicity. weight gain Tetracycline antibiotics should not be taken concurrently with what 3 things? dairy products, iron-containing preparations such as multivitamins, or antacids. Aminoglycosides are ______ toxic. They may also cause ________. renal  oto-  & neuro; neuromuscular blockade Are liver fxn studies indicated for gentamycin? No - it is NOT metabolized Erythromycin toxicity is related to _______ dysfunction and may manifest itself with  __________ pain. hepatic  right upper quadrant Clients experiencing drug-induced __________ will exhibit oliguria (low urine output). nephrotoxicity ______ or ______ may indicate an adrenergic response secondary to an allergic reaction (Cipro). Nervousness or anxiety Ciprofloxacin is excreted ________, and increasing  ________ will help to prevent drug accumulation in the _______. renally fluid intake kidneys Signs of anaphylaxis. edema of couth, tongue, pharynx, larynx confusion seizures, hallucinations hypotension leading to cardio collapse Ciprofloxacin (Cipro) therapy must be monitored carefully in clients with suspected ______ disorders, as this drug can be ________ at high doses, and can cause ______ when given by rapid IV infusion. CNS neurotoxic seizures