Dose of drugs Pethidine + Phenargan - 50mg+25mg IM sos Ketorolac 30mg IV tds Calcium dobesilate for varicose vein Tab cefadroxil 500mg BD Inj Phenytoin 100mg TDS Tab Cotrim DS 1 tab po BD Inj Octreotide 100micro gram sc TDS  10% calcium gluconate, 10ml over 10 minutes  Inj UFH 5000 IU SC BD Tab Strocit (Citicholine) 500mg PO BD Tab Stemetil (Prochloroperazone) 5mg IV sos Inj Rallidex NS (Dextran 40) - for hypovolemic shock/ septic shock/severe burns Seranace - haloperidol  Laxopeg - laxative + PEG  Inj Granisatron 1mg IV OD  Inj MgSO4, 1gm in 100ml NS IV over 4 hours Pain management Tab TRD contin 1 tab PO BD  Morphine 3mg TDS  Durogesic (Fentanyl transdermal patch) Local application for pain management  Syp Mor 5ml (2mg/ml) SOS Tab Morcontin 10mg PO sos Supportive medicines and total parenteral nutrition Pentasure + Soyaprotein 2tsf each in a glass of milk TDS  Triptene buscits 2piece BD  Inj Alanine I unit IV BD Inj Celemin (amino acids + sorbitol) I pint IV BD  Inj Celepid (intravenous fat) I pint IV OD  Inj Oliclinomol 1 litres IV over 16 hours and 8 hours gap  Use 10% dextrose in between the TPN to prevent hypoglycemia. TPN is given for 16 hours, and then 10% dextrose in eight hours Urinary system Tab flavoxate 200mg PO TDS -  anticholinergic, indicated for symptomatic relief of interstitial cystitis, dysuria, urgency, nocturia, suprapubic pain, frequency and incontinence as may occur in cystitis, prostatitis, urethritis Oxyspas (Oxybutynin) 2.5/5mg - anticholinergic-  to treat overactive bladder Tab Urimax (Tamsulosin) 0.4mg PO HS - alpha 1 adrenergic blocker Tab Alfuzosin 10mg PO OD - alpha 1 adrenergic blocker GI system drugs Itopride (Ganaton, Gantoon) 50mg PO TDS. It is a prokinetic benzamide derivative unlike metoclopramide or domperidone. It is used in dyspepsia of a non-ulcer/dysmotility type (gastric "fullness", discomfort, and possible pain), delayed gastric emptying and anorexia For ulcerative colitis  Mesacol (Meselamine) 400mg PO TDS - 1 hr before food or 2 hours after food Respiratory system drugs Seroflo rotacap - Contain salmeterol + Fluticasone Tiova - Tiotropium Nacfil (N acetylcysteine) 600mg PO tds as mucolytic agent Cardiovascular system Inj Amiodarone 900mg in 500ml NS over 24 hours. (amiodarone in 150mg/3ml injection) Amiodarone  - 1ml = 50mg, 1ampoule = 150mg  - How to prepare - 7ampoules (1050mg in 50ml (21ml drug + 29ml 5% dextrose)  - Bolus dose - 150mg over 10 minutes jQuery110101646906235989285_1485174722241jQuery110104313412200343545_1498016749827? GTN 30microgram/kg/min  Labetalol - bolus 2.5mg IV stat Tab Diazepam (NOTEN) 2mg PO BD Endocrine system Zoledronic acid 5mg/100ml IV infusion - is a biphosphonate used in Bone complications of cancer, osteoporosis and paget's disease Neuro drugs Tab Pregabalin 75mg PO BD Diamox (acetazolamide) 250mg TDS Immunosupresents - Immunosupressents in Renal Transplant  - Tab Pangraf (tacrolimus) 2.5mg PO BD  - Tab Mycofit (Mycophenolate) 1gm PO BD  - Tab Cortilone 20mg PO OD Anti-thymocyte globulin (ATG)  60mg in 500ml of NS -  is an infusion of horse or rabbit-derived antibodies against human T cells, which is used in the prevention and treatment of acute rejection in organ transplantation and therapy of aplastic anemia. Blood disease Neupogen (filgrastim)  0.5ml sc stat - is a  granulocyte colony-stimulating factor (G-CSF) analog, used to stimulate the proliferation and differentiation ofgranulocytes Acitrom (Acenocoumarol) 2mg  Enoxaparin (LMWX) 60mg SC ATT drugs dose HRZES  5, 10, 25, 15, 15 mg/kg/day Triple drug regimen in IV Inj Pantocid 40mg IV BD  Inj Clavum 1.2gm IV BD  Inj Levoflox 500mg IV BD Oral hypoglycemic drugs Tab Glycazide 5mg PO BD continue (for mild renal failure, upto grade III CKD) Insulin Fast acting - regular insuin (Huminsulin, Soluble insulin, actrapid) - insulin lispro (Humalog) - Insulin aspart (Novorapid)  Intermediate acting - NPH (Isophane, Insulatard) Long acting - Glargine (Lantus) - What is Mixtard? Mixtard contains both fast-acting (soluble) and long-acting (isophane) insulin: Mixtard 30: soluble insulin 30% and isophane insulin 70%; Mixtard 40: soluble insulin 40% and isophane insulin 60%; Mixtard 50: soluble insulin 50% and isophane insulin 50%. Novomix 30 -  - Soluble insulin aspart (rapidly-acting insulin, within 10 to 20 minutes) - Protamine-crystallised insulin aspart  (intermediate-acting insulin) -  It takes longer to act, but its effects last much longer. Cardiovascular system Tab TGR (Fenofibrate) 160mg OD for 3 months - to reduce cholesterol and triglyceride Renal system drugs Desmopressin (Minirin) 2 puff stat and repeat Inj Vasopressin 2U s/c stat If Urine output is >1000ml/hr, 500ml in two consecutive hour or >300ml in three consecutive hours Tab Fludrocortisone 200mg PO BD What is nupogen? Neupogen is used to stimulate the production of granulocytes (a type of white blood cell) in patients undergoing therapy that will cause low white blood cell counts Broad spectrum coverage Inj Tazopip 4.5 gm iv TDS  Inj Clindamycin 600mg iv TDS What to look for patients on anticoagulants New spots of bleeding  Intracranial bleeding leading to hypertension GIK 10U regular insulin with 10mEq/L  potassium in 500ml of 10% dextrose at 100ml/hr Uses in  - Myocardial infarction  - Septic shock Drug of choice for any bite Amoxyclave Antibiotics Cell wall inhibitors  - Inj Imipenam 500mg +Cilastatin 500mg - 1gm IV TDS or QID (Not more than 4gm/day and >1.5gm/dose) - Inj Meropenam 1gm IV in 100ml of NS BD  - Vancomycin (500mg in a vial)  - 10 mg/kg per dose given every six hours, concentrations of no more than 5 mg/mL and rates of no more than 10 mg/min are recommended in adults. Inj Acyclovir 800mg IV TDS - Inj Teicoplanin (Targocid) 400mg IV stat followed by 200mg IV OD. Teicoplanin is  Protein synthesis inhibitor  - Inj Clindamycin 600mg IV tds  - Inj Streptomycin 750mg IM OD Nucleic acid synthesis inhibitor  - Levofloxacin 750mg OD for hospital acquired pneumonia Tigecycline and Polymyxin B most strongest antibiotics, very expensive. Polymyxin B is an antibiotic primarily used for resistant Gram-negative infections Polymyxin B 5 lakhs units diluted in 500ml of 5% dextrose over 1-1.5 hours BD Inj Tigecycline 100mg IV stat followed by  50mg IV BD What is Teicoplanin? Teicoplanin owns a molecular structure which is related to that of vancomycin with similar spectrum of activity. Its mechanism of action is to inhibit peptidoglycan polymerization.  Due to its reduced rate of side effects that does not require close monitoring, its longer serum half-life and a simplified mode or application, teicoplanin is a valuable alternative of Vancomycin and has become the glycopeplide or choice in many hospitals. What is tigecycline? This antibiotic is the first clinically available drug in a new class of antibiotics called the glycylcyclines. It is structurally similar to the tetracyclines.  Tigecycline is active against - Gram-positive bacteria - Gram-negative bacteria - Anaerobes - Methicillin-resistant Staphylococcus aureus (MRSA) It has no activity against Pseudomonas spp. or Proteus spp. Alcohol withdrawal Tab Chlorodiazepoxide 15mg PO BD Trade names Magnex Forte - Sulbactam and cefoperazone Cilanem - Imipenam + Cilasten Tazobactam Decreases platelets Immunosupressant drugs Tab Tacrolimus 1mg po BD Tab Mycophenolate 500mg PO BD Different drugs available at Cholestyramine sachet in Norvik hospital Vitamins Thiamine  Riboflavin - 25, 50mg  Pyridoxine - 10mg tablet Unit and Pint Unit - 350 ml  Pint - 500 ml Pleurodesis Oxytetracycline (50mg/ml) - 20ml of Oxytetracycline (1gm) in 70ml of NS with 10ml of xylocaine,  tetracycline is irritant, so needs lignocaine Bicarbonate replacement Number of ampules =  (0.3 X base deficit X weight)/9 Ionotropes dose Dopamine and Dobutamine  - Dopamine - 1ampule - 200mg  - Dobutamine - 1ampule - 250mg  - preparation - body weight X 3 mg in NS/D5 - ml/hr = mcg/kg/min  - Dose - 5-20mch/kg/min  Noradrenaline/Adrenaline  - Noradrenaline - 1ampule - 4mg  - Preparation - 4mg in 50ml of NS/D5 - Dose - 0.01-0.3 mcg/kg/min GTN  - 1ampule - 25mg Goals of resiscutitation SBP > 90mmHg  MAP >65 mmHg  CVP 8-12 mmHg (12-15 mmHg in mechanically ventilated patients) Urine output - >0.5ml/kg/hr  ScVO2 >70% Doses of vasopressors Escalate every 5 minutes  Descelate every 30 minutes  Dopamine and dobutamine  - Preparation - body weight X 3 mg in 50ml NS/D5W - ml/hr = mcg/kg/min  - Dose - 5-20 mcg/kg/min  - Route - peripheral/central line  Noradranaline and adrenaline  - Preparation - 4mg in 50ml NS/D5W or 8mg in 100ml NS/D5W - Dose - 0.01-0.3 mcg/kg/min - Route - central line Hemorrhoids d Protek oinment - Lidocaine, Hydrocortisone, Zinc oxide and allantoin