Antitubercular Agents-End

Tuberculosis
- slow growth
- long treatment time (6-9 months)
First Line Anti-Tuberculosis drugs
Isoniazid
- ethambutol
- rifampin
- Pyrazinamide (cidal)
Second-Line Tuberculosis Agents
- cycloserine
- Kanamycin
- capreomycin
- ethionamide
- p-aminosalicylic acid
Isoniazid***
- Ethambutol
- Only active against dividing mycobacteria
- Pyrazinamide
- short term therapy
- hepatotoxicity
- used only in combination therapy
- P-Aminosalicylic Acid
- increases the level of free isoniazid
Rifamycins
- active against G+ and M. Tuberculosis
- Some G- and viruses
- Inhibitors of DNA directed RNA polymerase
- Bacteriocidal
- Rifampin
- most active agent for treatment of Tuberculosis
- Used only in combo
- Inducer of hepatic P450 Oxygenases
- Increases effects of aids medications
- Cycloserine
- prevents synthesis of cross-linking peptide in formation of bacterial cell walls
Anthelmintics

drugs that have the capability to rid the body of parasitic worms or helminths
Piperazine***
- Neurotoxic Anti-Helmintics
- Thiabendazole
- Inhibits fumarate reductase
Mebendazole

blocks glucose uptake
Ivermectin

treatment of "river blindness"
Benzylbenzoate***
- Lice treatment

Author

Anonymous

14087

Card Set

Antitubercular Agents-End

Description

medchem

Updated

2010-04-12T18:57:40Z

Show Answers