Path L3&4 acute/chronic inflammation.txt
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What color will neutrophils turn a serum?
What cell will increase angiogenesis, fibrosis and collagen production?
What molecule produces Arachidonic Acid?
What disease commonly contains epithelioid macrophages?
What will acute inflammation w/ ulceration lead to?
What molecules activate rolling of Neutrophils along endothelial cells?
- P/E selectin = endothelial cells
- L selectin = neutrophils
- Sialyl-Lewis ligand
What molecules modulate adhesion during transmigration?
Integrins interacting with the selectins (generally ICAM-1 and VCAM-1)
What is the mildest form of acute inflammation?
If a child has a normal WBC count, why would he have recurrent granulomatous disease?
defects in the NADPH oxidase system so no oxygen-dependent killing of bacteria occurs
What does the respiratory burst create?
ROS/RNS that will help with the microbicidal activity
What molecule and type of inflammation can cause liquefactive necrosis?
Neutrophils from Acute inflammation
How is interferon γ produced and what is its effect w/ inflammation?
- Produced by T-cells
- simulate monocytes & macrophages
- stimulates production of epithelioid cells and giant cells
What is the function of MPO?
to create HOCl- from H2O2 as an antimicrobial agent
If a person is having an ischemic injury, what mediator can be administered to impede further injury?
NO = vasodilation
How does endothelial contraction help with acute inflammation?
Endothelial contraction increases endothelial gaps so fluid can leave the capillaries to create edema
What deficiency prevents opsonization and phagocytosis of microbes?
What inhibits Cyclooxygenase?
COX-1&2, Aspirin, & other NSAIDS
What inhibits production of AA from Phospholipase C?
What are the three components of pus?
- Liquified tissue
- live neutrophils
- dead neutrophils
What molecule can be used to inhibit Factor V and thrombin production?
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