-
what is genetics
the study of DNA and its effects on the characteristics on an organism
-
What are the sub-disisplines of genetics?
- transmission genetics
- molecular genetics
- population genetics
- quantitive genetics
-
Transmission genetics or called classical genetics?(Gregor Mendel)
The study of the transfer of characteristics from one generation to the next.(mendalion genetics)
-
Molecular Genetics?(Watson and Crick)
Concentrates on the DNA molecule it self and on the protien and the RNA that are made from that molecule.
-
population genetics?(Discreat varations)
- looking at groups of organisms, measuring frequencys and how often a genotype or phenotype or allele occurs.
- Traits that are controlled by one or two genes
- EX. can count numbers of individuals in each group.
-
Quantitative genetics?(continuous varation)
- Looking at groups of organisms, measuring frequencys and how often a genotype or phenotype or allele occurs.
- Deals with multigenetics or controled by many different genes.
- EX. people hieght.
-
Central Dogma?(Molecular genetics)
- DNA is able to make more DNA(replication)
- DNA is able to form the molecule RNA(transcription)
- RNA is used to make protiens(translation)
- RNA is used to make DNA(reverse transcription)
- Need to be able to draw pic in notes.
-
Techniques used to study genetics?
- Choose model organism
- Mating,cytology,Biochemestry-genetic dissection(beadle and tadum), direct analysis
- Genetics data ases
-
Genetic Recombination?
- Taking DNA from one organism and inserting into another organism.
- EX. Like insulin into ecoli
-
Genetic Data Bases?
- NCBI(national center for biotechnoligy information)
- PubMed(published med papers)
- OMIM(online mendalion Inheritance in men)
- GenBank(stores all DNA sequences that have been discovered)
- Blast(used for comparing one sequence to another)
-
genetic diseases?
- Inherited-diseases that are passed on because of one or more faulty alleles,(type 2 diabetes, color blindness, cicle cell anema)
- Soamtic-mutation that happen in body cells, not inherited(cancer)
- Chromosomal-Down syndrome, which happens because of an abnormal number of chromosomes.
-
Eukayotic?
- has true nucleous and membrane bound organelles.
- domain is called Eukarea
-
Prokaryotic?
- no nucleous and membrane enclosed organelles
- Domains-Archea, Bateria
-
Genotype?
The alleles that are carried by a paticular cell.
-
Phenotype?
The physical characteristics that you observe expressed by the genotype.
-
Gene?
- A section of DNA that can be transcribed.
- EX. mRNA translated into protien.
-
Allelle?
Different forms that a gene can exsist in.
-
Genome?
- All of the DNA found within a single cell.
- Diploid organisms have two genomes in there cell.
-
Proteome?
All of the protiens that can be made by a specific cell.
-
Diploid?
Two copies of a genome.
-
Haploid?
1 copy of a genome
-
Homozygous?
The two alleles for a gene are the same(P1 generation).
-
Heterozygous?
The two alles for a gene are different(F1 generation)
-
Dominant?
A phenotype which occurs when there is either one or two copies of the allele present.
-
Ressesive?
A phenotype that occurs only when there is no dominant allele present.
-
What is a Chromosome?
sequence of DNA that contains genes and an origin of replication plus its associated protiens.
-
chromatin?
is a chromosome in its uncondensed form
-
Monad?
unreplicated chromosome containing one molecule of DNA, seen in G1 phase or G0
-
Dyads?
replicated chromosomes seen in G2 phase.
-
tetrads?
only occur in mieosis, when two homologous dyads come together, crossing over occurs here, cant be seen in mieosis2
-
chromatid?
One half of a dyad or replicated chromosome.
-
homologous chromosomes?
Chromosomes that are the same size, shape and carry the same genes, but they have different alleles.
-
Are sister chromatids identical?
yes they are id3entical unless a mutation has occured during the prosess of replication.
-
Centromere?
Last part to replicate, looks constricted.
-
Ends of chromosomes?
telomeres
-
metacentric chromosomes?
centromere is right in the middle.
-
submetacentric chromosomes?
offset about 3/4 of the way up.
-
Acrocentric chromosomes?
Offset about 7/8 of the way up, probably wont be on test.
-
telocentric chromosomes?
centromere is right on the end of the chromosome cant really see constriction, only has one arm.
-
P arm
short arm of chromosomes
-
q arm?
long arm of chromosomes.
-
Chromosome theory of inheritance?
(sutton and boveri) the partical or gene that were described by mendal are carried on chromosomes.
-
Karyotype?
is a picture of the chromosomes from a single cell
-
Cytological map?
- Is a description of where genes are located on a chromosomes based on what the chromosome looks like under a microscope.
- Units are arms and bands
-
Linkage Maps
- produced by test crosses to produce a linkage map.
- units are map units (represents 1% recombination) used to be called centimorgans .
-
physical maps
most accurate, units for phisical maps are base pairs.
-
autosomes
- all chromosomes other then sex chromosomes.
- humans have 2 pair
-
how many chromosomes do humans have?
23 pair
-
Probability?
the number of possible ways for an event divided by the total number of possible events
-
Independent events?
dont influence each other
-
The product rule?
the probability that two independent events will occur at the same time is equal to the product of there individual probability. "AND" is the hint.
-
The sum law (mutually exclusive events)?
- the probability of observing two or more possible mutually exclusive events is equal to the sum of there probability. "OR" hint.
- EX. roll one dye what is the probability of getting an even number. 1/6+1/6+1/6=3/6
-
What 3 abilities do genetic materails have to have to be genetic material?
-
what characteristics of the DNA molecule allow it to carry out those three function?
- complimentary base pairing
- specific binding of proteins to specific sequences.
|
|