HTN

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Author:
mct12188
ID:
100857
Filename:
HTN
Updated:
2011-09-10 11:54:29
Tags:
HTN
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Description:
HTN
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  1. primary (essential) HTN
    > 90% of hypertensive patients

    unknown pathophysiologic etiology

    Can’t be cured

    Genetic factors
  2. secondary HTN
    • < 10%
    • HTN cause by something else
    • cormid conditon - meds - drugs - foods
    • want to treat/correct the underlying condition to help correct the HTN
  3. isolated systolic HTN
    DPB < 90 mm Hg with SBP ≥ 140

    Results from pathophysiologic changes in arterial vasculature consistent with aging

    SBP is a strong predictor of CV disease in patients ≥ 50 years old

    • Pulse pressure = SBP – DBP
    • - Reflects extent of atherosclerotic disease in elderly
    • - pulse pressure, ­ CV mortality
    • - Measures arterial stiffness
  4. HTN related target-organ damage
    • eyes
    • brain
    • heart
    • kidneys
    • peripheral blood vessels
  5. CV risk factors
    • Age ≥ 55 years for men -
    • 65 for women
    • DM
    • obesity
    • tobacco
    • microalbuminuria
    • dyslipidemia
  6. Mechanism of pathogenesis
    BP
    BP = CO x TPR

    • ↑ Cardiac output
    • - Increased cardiac preload
    • - Venous constriction

    • ↑ peripheral resistance
    • - Functional vascular constriction
    • - Structural vascular hypertrophy
  7. Thiazide Diuretics
    • MOA - blocks Na/Cl transporter
    • = causes Inc. excretion of Na/Cl and water follows

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