Card Set Information
Determine the concentration of a drug at its sites of action and thereby determine the intensity and time course of responses.
Absorption, distribution, metabolism, excretion
Movement of a drug from its site of administration into the blood.
Movement of drugs throughout the body.
Enzymatic alteration of drug structure
What's the name of the enzyme at the liver?
Cytochrome P450 system
Induction of drug-metabolizing enzymes = induce synthesis of hepatic drug-metabolizing enzymes
Increase metabolism of endegenous compounds and drugs.
Rapid inactivation of some oral drugs as they pass through the liver after being absorbed.
Where does metabolism occur?
Where does excretion occcur?
3 Steps of Renal Drug Excretion:
1. Glomerular filtration
2. Passive Tubular Reabsorption
3. Active Tubular Secretion
Created by the liver and stored at gallbladder.
Liver create a bile to release at small intestine and undergo reabsorption.
Minimum Effective Concentration (MEC)
Plasma drug level below which therapeutic effects will not occur.
Therapeutic Range (TR)
Range of a drug lies between the MEC and the toxic concentration.
Time required for the amount of drug in the body to decline by 50%.
When plateau must be achieved quickly, a large initial dose is administered.
A plateau is maintained by administering small doses.