Pharmacokinetics

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Author:
mabogado
ID:
101121
Filename:
Pharmacokinetics
Updated:
2011-09-11 19:16:24
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Pharmacokinetics
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Pharmacokinetics
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  1. Define pharmacokinetic.
    Determine the concentration of a drug at its sites of action and thereby determine the intensity and time course of responses.
  2. Pharmacokinetics processes:
    Absorption, distribution, metabolism, excretion
  3. Absorption
    Movement of a drug from its site of administration into the blood.
  4. Parental
    Injection
  5. Intravenous(IV)
    Vein
  6. Subcutaneous(subQ)
    Fat, skin
  7. Intramuscular(IM)
    Muscle
  8. Distribution
    Movement of drugs throughout the body.
  9. Induction
    Promote
  10. Inhibition
    prevent
  11. Metabolism/Biotransformation
    Enzymatic alteration of drug structure
  12. What's the name of the enzyme at the liver?
    Cytochrome P450 system
  13. Induction of drug-metabolizing enzymes = induce synthesis of hepatic drug-metabolizing enzymes
    Increase metabolism of endegenous compounds and drugs.
  14. First-pass effect
    Rapid inactivation of some oral drugs as they pass through the liver after being absorbed.
  15. Where does metabolism occur?
    Liver
  16. Where does excretion occcur?
    Kidneys
  17. 3 Steps of Renal Drug Excretion:
    • 1. Glomerular filtration
    • 2. Passive Tubular Reabsorption
    • 3. Active Tubular Secretion
  18. Define bile.
    Created by the liver and stored at gallbladder.
  19. Enterohepatic recirculation
    Liver create a bile to release at small intestine and undergo reabsorption.
  20. Minimum Effective Concentration (MEC)
    Plasma drug level below which therapeutic effects will not occur.
  21. Therapeutic Range (TR)
    Range of a drug lies between the MEC and the toxic concentration.
  22. Half-Life
    Time required for the amount of drug in the body to decline by 50%.
  23. Loading dose
    When plateau must be achieved quickly, a large initial dose is administered.
  24. Maintenance dose
    A plateau is maintained by administering small doses.

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