Pharmacodynamics

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Author:
mabogado
ID:
101140
Filename:
Pharmacodynamics
Updated:
2011-09-11 21:14:16
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Pharmacodynamics
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Pharmacodynamics
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  1. Pharmacodynamics
    Study of the biochemical and physiologic effects of drugs and the molecular mechanisms by which those effects are produced.
  2. Graded (phase 2)
    Response gets more intense with increasing dosage.
  3. Maximal Efficacy
    Biggest effects a drug can produce.
  4. Potent Drug
    Drug that produces its effects at low doses.
  5. Receptor
    Functional macromolecule in a cell to which a drug binds to produce its effects.
  6. Drugs/foreign drugs
    Mimic or block the action of the body's own regulatory molecules and alter the rate.
  7. Four Primary Families of Receptors
    • 1. Cell membrane-embedded enzymes
    • 2. Ligand-gated ion channels
    • 3. G protein-coupled receptor systems
    • 4. Transcription factors
  8. Selective drug action
    Drug interacts with one type of receptor and receptor regulates a few processes.
  9. Nonselective drug action
    Drug interacts with multiple receptor and receptor regulates multiple processes.
  10. Affinity
    • 1. Strength of the attraction between a drug and its receptor.
    • 2. Inc affinity Inc potency
  11. Intrinsic Activity
    • 1. Ability of a drug to activate receptors.
    • 2. Inc intrinsic activity Inc maximal efficacy
  12. Agonists
    • 1. Molecules that activate receptors.
    • 2. Modified Occupancy Theory: yes affinity, yes intrinsic activity
  13. Antagonists
    • 1. Drugs that prevent receptor activation by endogenous regulatory molecules and by other drugs.
    • 2. Modified Occupancy Theory: yes affinity, no intrinsic activity
  14. Noncompetitive Antagonists
    Binds irreversibly to receptors.
  15. Competitive Antagonists
    Binds reversibly to receptors.
  16. Partial Agonists
    Can act as agonists and antagonists and have moderate intrinsic activity.
  17. Desensitization/refractoriness/down-regulation
    Over exposure of cells to agonists.
  18. Hypersensitivity/supersensitivity
    Over exposure of cells to antagonists.
  19. ED50
    Dose required to produce a defined therapeutic response in 50% of the population.
  20. Therapeutic Index
    • 1. LD50:ED50 ratio
    • 2. High TI = safe
    • 3. Low TI = unsafe

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