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  1. Cyt p 450 inducers?
    • Quinidine
    • Barbituates
    • St. Johns Wart
    • Phenytoin
    • Rifampin
    • Griseofulvin
    • Carbamezapine
    • Chronic EtOH use
  2. Cyt p 450 inhibitors
    • HIV protease inhibitors
    • Ketoconazole
    • Erythromycin
    • Grapefruit Juice
    • Acute EtOH
    • Cimetidine
  3. What is the Infusion Rate? Ko?
    Cl x CSS
  4. What is the LD?
    Vd x Css
  5. What is the MD?
    Vd x Css x dosing interval
  6. What is the Clearance?
    Vd x k
  7. What is Vd?
  8. What is t1/2?
    0.7 x Vd/CL
  9. What receptors signal thru the q arm of the G protein?
  10. What is the signalling pathway for the q arm of G protein?
    • phospholipase c--- +IP3-- + Ca
    • DAG---- + Protein Kinase C
  11. What receptors signal thru the stimulatory arm of G protein?
    b1, b2, H2, V2, D1
  12. What is the signalling pathway for the s arm of the G protein?
    +AC--- +cAMP----+ protein Kinase A
  13. What receptors signal thru the Inhibitory arm of the G protein?
    M2, A2, D2
  14. What is the signalling pathway for the Inhibitory arm of the G protein?
    ----- - AC------ -cAMP------ - Protein Kinase A
  15. Ach affects what two muscles in the eye on the parasympathetic arm?
    • sphincter --pupil--meiosis
    • Ciliary muscle--Lens
  16. NE affects what muscle in the eye?
    radial muscle---mydriasis
  17. Cycloplegia?
    paralysis of accomodation
  18. Keratitis?
    corneal Inflammation
  19. 2 Cholinomimetic Drugs for Glaucoma?
    • Carbachol
    • Pilocarpine
    • Contract Ciliary muscle--increase flow thru canal of schlemm
  20. Ach esterase inhibitor for Glaucoma?
    • Ecothiophate
    • Increase Outflow
  21. 2 Beta blockers for Glaucoma?
    • Betaxolol
    • Timolol
    • Block NE at ciliary epithelium
    • decrease Aqueous humor formation
  22. 2 Sympatomimetic for Glaucoma?
    • Apraclonidine--blocks NE at prejunction
    • Epinephrine---Increase Outflow
  23. 2 carbonic anhydrase inhibitors for Glaucoma?
    • Acetozolamide
    • Dorzolomide
    • Decrease HCO3 production --decreased Acqueus Humor
  24. PGF2 for Glaucoma?
  25. Selective Beta 2 agonists for Asthma?
    • Metaproterenol
    • Albuterol
    • Salmeterol
    • Terbutaline
  26. Uptake inhibitor of Choline at the nerve ending?
  27. MOA of botulinum toxin?
    inhibits release of Ach from the synaptic membrane
  28. Botulinum toxin binds to what membrane protein?
  29. What is the motor neuron used for signalling skeletal muscle?
    alpha neuron
  30. Treatment for Strabismus?
    botulinum toxin
  31. Hyperhydrosis?
    excessive sweating
  32. Treatment for Hyperhydrosis?
    botulinum toxin
  33. Muscaranic receptors are found in what 3 locations?
    • Heart
    • secretion glands
    • Smooth muscle
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