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Cyt p 450 inducers?
- St. Johns Wart
- Chronic EtOH use
Cyt p 450 inhibitors
- HIV protease inhibitors
- Grapefruit Juice
- Acute EtOH
What is the Infusion Rate? Ko?
Cl x CSS
What is the MD?
Vd x Css x dosing interval
What is the Clearance?
Vd x k
What is t1/2?
0.7 x Vd/CL
What receptors signal thru the q arm of the G protein?
What is the signalling pathway for the q arm of G protein?
- phospholipase c--- +IP3-- + Ca
- DAG---- + Protein Kinase C
What receptors signal thru the stimulatory arm of G protein?
b1, b2, H2, V2, D1
What is the signalling pathway for the s arm of the G protein?
+AC--- +cAMP----+ protein Kinase A
What receptors signal thru the Inhibitory arm of the G protein?
M2, A2, D2
What is the signalling pathway for the Inhibitory arm of the G protein?
----- - AC------ -cAMP------ - Protein Kinase A
Ach affects what two muscles in the eye on the parasympathetic arm?
- sphincter --pupil--meiosis
- Ciliary muscle--Lens
NE affects what muscle in the eye?
paralysis of accomodation
2 Cholinomimetic Drugs for Glaucoma?
- Contract Ciliary muscle--increase flow thru canal of schlemm
Ach esterase inhibitor for Glaucoma?
- Increase Outflow
2 Beta blockers for Glaucoma?
- Block NE at ciliary epithelium
- decrease Aqueous humor formation
2 Sympatomimetic for Glaucoma?
- Apraclonidine--blocks NE at prejunction
- Epinephrine---Increase Outflow
2 carbonic anhydrase inhibitors for Glaucoma?
- Decrease HCO3 production --decreased Acqueus Humor
PGF2 for Glaucoma?
Selective Beta 2 agonists for Asthma?
Uptake inhibitor of Choline at the nerve ending?
MOA of botulinum toxin?
inhibits release of Ach from the synaptic membrane
Botulinum toxin binds to what membrane protein?
What is the motor neuron used for signalling skeletal muscle?
Treatment for Strabismus?
Treatment for Hyperhydrosis?
Muscaranic receptors are found in what 3 locations?
- secretion glands
- Smooth muscle
What would you like to do?
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