Pharm of accessory
Card Set Information
Pharm of accessory
what happens with chronic exposure of agonist? of antagonist?
agonist = down regulation
antagonist= up regulation
on postsynaptic a1 receptor?
vasoconstriction, mydriasis, increase HR contractility, increase sphincter contractility (GI, bladder), relax GI, decrease insulin release
on presynaptic a2 receptor?
DECREASE SYMPATHETIC OUTFLOW
DECREASE INSULIN RELEASE
DECREASE NE RELEASE FROM POSTSYNAPTIC MEMBRANES i.e clonidine, precedex
postsynaptic a2 receptors?
postsynaptic B1 receptor?
increase Heart contractility
postsynaptic B2 receptor
VASODILATION, BRONCHODILATION, STIMULATES INSULIN RELEASE,
GI RELAXATION, UTERIN RELAXATION, BLADDERRELAXATION, GLYCOGENOLYSIS, LIPOLYSIS, STIMULATION OF SODIUM/POTASSIUM PUMP
Dopa 1 receptor
dopa 2 receptor?
decrease sympathetic outflow
describe adrenergic transmission of tyrosine to NE?
1.Tyrosine enters terminal dendrite
2.Tyrosine is converted into dopamine
3.Via ATP, dopamine gets vesicle around*(reserpine blocks it)
4.Dopamine is converted to NE
5.Ca+ carries vesicle to wall
6.NE released into synapse
7.NE:Reaches postsynaptic cleft and contacts α1α2β1β2
Is metabolized in synapse by “MAO” into dopamine or tyrosine( gets reused)
Reaches presynapticcleft α2 ONLY (acts as an autoreceptorfor autonomic NS)
what are the steps in cholinergic transmission?
1.Choline enters terminal dendrite
2.Cholinejoins acetyl-coenzyme A and forms ACh
3.Via ATP, ACh gets vesicle around it
4.Ca+ comes into terminal dendrite and carries vesicle to wall
5.ACh released into synapse
6.ACh:a)Reaches postsynaptic cleft and contacts nicotinic or muscarinic receptor
b)Is metabolized by acetylcholinesterase
i. choline is reused (it is the presynaptic reuptake of choline that is main regulator of ACH)
ii. Acetate is waste product
c)Reaches synaptic cleft then contact autoreceptors that tell axon to stop producing ACh because of accumulation
what are nicotinic receptors stimulated by? blocked by?
stimulated by nicotine, ACH, Mech, DMPP
blocked by Hexa and decathmethomium d tubbocurare
what are the 2 types of nicotinic recpetors? what are they stimulated by? blocked by?
Ganglionic is stimulated by Nictoine, ACH, DMPP and blocked by Hexamethonium and d tubocurare
Neuromuscular is stimulated by Nicotine, ACH
blocked by decamethonium and atropine
what stimulated muscarinic receptors? blocks them?
stimulated by muscarine, ACH, CCH, MEch,
blocked by atropine, scopolamine
what blocks the muscarinic receptors?
blocked by atropine, dicyclomine, pirezepine, gallamine, HHSD