Pharm of accessory

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Author:
pearlsdtr
ID:
101753
Filename:
Pharm of accessory
Updated:
2011-09-14 19:16:36
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ANS
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Description:
fall 2011
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  1. what happens with chronic exposure of agonist? of antagonist?
    • agonist = down regulation
    • antagonist= up regulation
  2. on postsynaptic a1 receptor?
    vasoconstriction, mydriasis, increase HR contractility, increase sphincter contractility (GI, bladder), relax GI, decrease insulin release
  3. on presynaptic a2 receptor?
    • DECREASE SYMPATHETIC OUTFLOW
    • DECREASE INSULIN RELEASE
    • DECREASE LIPOLYSIS
    • DECREASE NE RELEASE FROM POSTSYNAPTIC MEMBRANES i.e clonidine, precedex
  4. postsynaptic a2 receptors?
    • platelet aggregation
    • CNS hyperpolarization
  5. postsynaptic B1 receptor?
    • increase Heart contractility
    • increase HR
  6. postsynaptic B2 receptor
    • VASODILATION, BRONCHODILATION, STIMULATES INSULIN RELEASE,
    • GI RELAXATION, UTERIN RELAXATION, BLADDERRELAXATION, GLYCOGENOLYSIS, LIPOLYSIS, STIMULATION OF SODIUM/POTASSIUM PUMP
  7. Dopa 1 receptor
    • RENAL VASODILATION
    • MESENTERIC VASODILATION
  8. dopa 2 receptor?
    decrease sympathetic outflow
  9. describe adrenergic transmission of tyrosine to NE?
    • 1.Tyrosine enters terminal dendrite
    • 2.Tyrosine is converted into dopamine
    • 3.Via ATP, dopamine gets vesicle around*(reserpine blocks it)
    • 4.Dopamine is converted to NE
    • 5.Ca+ carries vesicle to wall
    • 6.NE released into synapse
    • 7.NE:Reaches postsynaptic cleft and contacts α1α2β1β2
    • Is metabolized in synapse by “MAO” into dopamine or tyrosine( gets reused)
    • Reaches presynapticcleft α2 ONLY (acts as an autoreceptorfor autonomic NS)
  10. what are the steps in cholinergic transmission?
    • 1.Choline enters terminal dendrite
    • 2.Cholinejoins acetyl-coenzyme A and forms ACh
    • 3.Via ATP, ACh gets vesicle around it
    • 4.Ca+ comes into terminal dendrite and carries vesicle to wall
    • 5.ACh released into synapse
    • 6.ACh:a)Reaches postsynaptic cleft and contacts nicotinic or muscarinic receptor
    • b)Is metabolized by acetylcholinesterase
    • i. choline is reused (it is the presynaptic reuptake of choline that is main regulator of ACH)
    • ii. Acetate is waste product
    • c)Reaches synaptic cleft then contact autoreceptors that tell axon to stop producing ACh because of accumulation
  11. what are nicotinic receptors stimulated by? blocked by?
    • stimulated by nicotine, ACH, Mech, DMPP
    • blocked by Hexa and decathmethomium d tubbocurare
  12. what are the 2 types of nicotinic recpetors? what are they stimulated by? blocked by?
    • Ganglionic is stimulated by Nictoine, ACH, DMPP and blocked by Hexamethonium and d tubocurare
    • Neuromuscular is stimulated by Nicotine, ACH
    • blocked by decamethonium and atropine
  13. what stimulated muscarinic receptors? blocks them?
    • stimulated by muscarine, ACH, CCH, MEch,
    • blocked by atropine, scopolamine
  14. what blocks the muscarinic receptors?
    blocked by atropine, dicyclomine, pirezepine, gallamine, HHSD

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