Diabetes Medications 1

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Author:
jdonaldson
ID:
101948
Filename:
Diabetes Medications 1
Updated:
2011-09-15 17:11:32
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james James donaldson Donaldson usp USP diabetes Diabetes medication Medication
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... but I don't even like pharmacy anymore!
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  1. What medications are classified as biguanides?
    Metformin
  2. What is metformin's brand name?
    Glucophage
  3. What is the HbA1C lowering effect of metformin (glucophage)?
    1.5 - 2.0 %
  4. Which medication works by enhancing insulin sensitivity in hepatic and muscular tissue, allowing for increased glucose uptake? (No direct effect on beta-cells)
    Metformin (glucophage)
  5. List the four first generation sulfonylureas (generic and brand) -
    • 1. acetohexamide (Dymelor)
    • 2. clorpropamide (Diabinese)
    • 3. tolazamide
    • 4. tolbutamide (Orinase)
  6. List the four second generation sulfonylureas (generic and brand) -
    • 1. glipizide (glucotrol)
    • 2. glyburide (DiaBeta)
    • 3. micronized glyburide (glynase)
    • 4. glimiperide (amaryl)
  7. What is the HbA1C lowering effect of the sulfonylureas?
    1.5 - 2.0 %
  8. What medication enhances insulin secretion from pancreatic beta cells by binding to a receptor linked to closing a K+ efflux channel, depolarizing the membrane, opening voltage-gated calcium channels and thus causing translocation of insulin granules?
    • Sulfonylureas
    • (receptor is the SUR)
  9. What drugs are classified as meglitinides? (brand and generic)
    • 1. nateglinide (starlix)
    • 2. repaglinide (prandin)
  10. What is the brand name for nateglinide?
    Starlix
  11. What is the brand name for repaglinide?
    Prandin
  12. What is the brand name for glipizide?
    Glucotrol
  13. What is the brand name for glyburide?
    DiaBeta
  14. What is the brand name for micronized glyburide?
    Glynase
  15. What is the brand name for glimiperide?
    Amaryl
  16. What is the HbA1C lowering effect of the meglitinides?
    0.5 - 1.0 %
  17. What medications work by stimulating insulin secretion from pancreatic beta cells by binding to a site adjacent to the SUR (requiring the presence of glucose for action)?
    The meglitinides
  18. What drugs are classified as thiazolinediones (TZDs/glitazones)?
    • 1. pioglitazone (Actos)
    • 2. rosiglitazone (Avandia)
  19. What is the brand name for pioglitazone?
    Actos
  20. What is the brand name for rosiglitazone?
    Avandia
  21. What medications act by binding to peroxisome proliferator-activated receptor (PPAR-gamma), indirectly increasing insulin sensitivity at muscle, liver and fat cells (requires presence of insulin)?
    The thiazolidinediones (TZDs/glitazones)
  22. What medications are classified as alpha-glucosidase inhibitors?
    • 1. acarbose (Precose)
    • 2. miglitol (Glyset)
  23. What is the HbA1C lowering effect of TZDs?
    0.5 - 1.5 %
  24. What is the brand name for acarbose?
    Precose
  25. What is the brand name for miglitol?
    Glyset
  26. What is the HbA1C lowering effect of the alpha-glucosidase inhibitors?
    0.3 - 1.0 %
  27. What medications act by competitively inhibiting intestinal enzymes to delay the breakdown of sucrose and carbohydrates, reducing post-prandial BG rise?
    The alpha-glucosidase inhibitors
  28. What medications are classified as DPP-IV inhibitors?
    • 1. sitagliptin (Januvia)
    • 2. saxagliptin (Onglyza)
    • 3. vildagliptin
  29. What is the brand name of sitagliptin?
    Januvia
  30. What is the brand name of saxagliptin?
    Onglyza
  31. What is the HbA1C lowering effect of the DPP-IV inhibitors?
    0.4 - 0.8 %
  32. What medications prolong the t1/2 of endogenous GLP, reducing glucagon levels and stimulating glucose dependent insulin secretion (does not alter gastric empyting)?
    DPP-IV inhibitors

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