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Endogenous nucleoside (occurs naturally in all cells of the body)
Adenosine is a naturally occurring nucleoside
- 1. Slows conduction through the AV node
- 2. Interrupts reentry pathways through the AV node and SA node -converting SVT to NSR
- 3. Depresses automaticity in the SA node
Used in the treatment of paroxysmal supraventricular tachycardia (PSVT) refractory to vagal maneuvers.
- 1. History of sick sinus syndrome
- 2. Second or third degree block
- 3. Known hypersensitivity
- 4.Bronchospasms associated with asthma
- Limited to duration of adenosine’s half life
- 1. SOB / Dyspnea; may cause bronchospasm in asthma patients (BHO).
- 2. Chest pressure / palpitations; may be acute in some patients for brief period.
- 3. Mild hypotension (decreased peripheral vascular resistance).
- 4. Dizzy / lightheadedness /headache
- 5. Nausea
- 6. Transient arrhythmias; (bradycardia, AV blocks,
- ventricular ectopy). These are generally not treated and are quickly self-limiting.
Adult: Initial dose 6mg rapid IVP followed by a 20cc saline flush. Refractory to initial dose may repeat X2 with 12mg after 1-2 min.
Peds: 0.1mg/kg rapid IVP followed by a 2-3mL saline flush. Refractory to initial dose may repeat X1 with 0.2 mg/kg after 1-2 min.
- Immediate, half-life <10
- seconds Special Information: (Concentration: 6mg / 2ml)