Pathology Ch 5

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Pathology Ch 5
2011-09-17 13:31:28
USUHS Pathology Disease Immune System

Pathology Ch 5
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  1. Name the generative lymphoid organs
    • Thymus
    • Bone Marrow
  2. Name the peripheral lymphoid organs
    • Lymph nodes
    • Spleen
    • Mucosal/cutaneous lymphoid lissue (GI and resperatory tracts)
  3. Describe lymph node follicles
    • B cell concentration at periphery of node
    • Contain follicular dendritic cells for B cell activation
    • Forms GERMINAL CENTER when activated
  4. Where are T cells found in lymph nodes?
    Paracortex (adjacent to follicles)
  5. What is the HLA?
    • Human leukocyte antigen complex
    • Genes on chromosome 6
    • Encode MHC (major histocompatibility complex)
  6. HLA haplotype
    Combination of MHC genes in any given individual
  7. Immediate (Type I) Hypersensitivity
    • Anaphylaxis, allergies, asthma
    • Production of IgE antibody and release of mediators by mast cells
  8. Antibody-mediated (type II) Hypersensitivity
    • Autoimmune hemolytic anemia
    • Goodpasture syndrome
    • Production of IgG, IgM to antigen on target cells/tissue
  9. Immune complex-mediated (Type III) Hypersensitivity
    • Systemic lupus erythematosus
    • Deposition of antigen-antibody complexes and complement activation
  10. Cell-mediated (Type IV) Hypersensitivity
    • Contact dermitits, multiple sclerosis, type I diabetes, rhematoid arthritis, inflammatory bowel disease
    • Activated T lymphocytes (inflammation and cytotoxicity)