Dose Form Definitions

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  1. Apothacary
    Wiseman, priest, magician, smart person in tribe
  2. Pharmacopeia
    Offical compendum, formulary, a book containing a compilation of pharmaceutical products with their formulas and methods of preparation
  3. USP
    • Information on pharmaceutical products including, indications, dosage forms, side effects and pharmacology
    • Drug substances and preparations
    • Dietary ingrediants and supplements
  4. NF
    Popular drugs and preps not admitted originally to the USP, pharmaceutical ingrediants
  5. International Pharmacopeia
    pupished by the World Health Organization (WHO)
  6. Homepathic Pharmacopeia of the United States
    Likes cure like
  7. FDA
    Safety and effectiveness
  8. Legend drugs
    too dangerous for self medications
  9. Schedule drugs
    public abuse
  10. Recombinat DNA
    manipulation of cells protein from lower organism
  11. Monoclonal Antibody
    Manipulation of cells proteins from higher animals including the patient
  12. Gene therapy
    Modification of genetic material of living cells
  13. Stem cell
    self renewing cells
  14. Somatic cells
    end-stage differentiated cells
  15. goal drug
    the ideal drug with full therapeutic effect with no side effects
  16. Lead Compound
    Compound with the desired pharmcologic/biologic activity
  17. Prodrug
    A drug that is inactive until it is metabolized by the body to become pharmcologically active
  18. Empircal formula
    the number of atoms per compound
  19. Systematic formula
    The relative location of the atoms in the compound
  20. USAN
    United States Adopted Names, gives the non-proprietary names
  21. NDC
    National Drug Code, first 4 labelor code, product code, package code
  22. Clinical Investigator
    investigation is conducted according to the signed investigator statement, the investigational plan, and applicable regulations; for protecting the rights, safety, and welfare of subjects
  23. Sponsor
  24. IRB
    Instituitional Review Board (ethics committee)
  25. Dosage form
    is the physical form of a dose of a chemical compound used as a drug or medication intended for administration or consumption. Common dosage forms include pill, tablet, or capsule, drink or syrup, aerosol or inhaler, liquid injection, pure powder or solid crystal
  26. Crystal Form
    Less soluable then the amorphous form
  27. Amorhphous form
    more soluable than the crystal form
  28. CGMP
    Current Good Manufacturerng Practices
  29. Reaction rate
    Drug concentration vs time
  30. Zero Order Reaction
    Drug loss is independant of concentration, contant with time
  31. First Order Reaction
    Drug loss is directly proportional to concentration remaining with respect to time
  32. Q10
    Method of shelf life estimation
  33. Pharmaceutic ingrediants
    excipients, non-therapeutic ingrediants
  34. ADME
    • Absorption
    • Distribution
    • Metabolism
    • Elimination
  35. Pharmacokinetics
    • The study of the time course of drug concentration and in tissues
    • The study of th rate and extent of absorption/excretion
  36. Absorption
    Dissolution of drug in fluids and entrance into circulation
  37. Disintegration
    tablets/capsule into granules
  38. Deaggragation
    Granules into fine powder
  39. Wetting
    The fine particles get wet int the body fluids
  40. Dissolution
    • Fine particles into liquid
  41. Solution
    Drug in a form of a liquid
  42. Biologic Membrane
    Biomolecule lipid bilayer plus protein layer with water filled pores/channels
  43. Passive diffusion
    The rate of transport across a membrane is prortional to the difference in drug concentration on both sides of the membrane
  44. Active transport
    Dirven against concentration gradient
  45. Facilatated Diffusion
    the movement of molecules across a membrane from a region of high concentration to a region of low concentration that is assisted by proteins
  46. Bioavailability
    The rate the extent of absorption and availability of the drug at the actve site
  47. Bioequivalance
    Comparison of bioavailbility
  48. Orange Book
    Approved drug products with therapeutic equivalance evaluations
  49. Cmax
    The maximum concentration of drug in blood
  50. Tmax
    The time it takes to get to the maximum concentration in blood
  51. AUC
    area under the curve, directly proportional to absorption, if the auc is the same then the amount absorbed and excreted is the same
  52. Distribution
    Fate of drug after absorption
  53. Unbound drug
    • Active
    • Free to leave the circulation to enter tissues and cellular sites
  54. Bound Drug
    • Inactive
    • Is neither metabolized nor filter through the kids
  55. Metabolism
    which in living organisms is the sum of all chemical transformations catalyzed by enzymes and allowing the transformation of biological molecules
  56. Excretion
    termination of drugs activity and presence in the body
  57. Vd
    • Volume of distribution
    • Volume of the compartment into which the total amount of drug is distributed
  58. T1/2
    • Half Life
    • The time for the blood's concentration of drug to decrease by half
  59. Cl
    • Clearance
    • Removal of drug from body
  60. Dose Regimen
    How much and how often
  61. Empirical Approach
    • pg 180
    • Administration of a drug in a certain way then observing the therapeutic effect
  62. Kinetic Approach
    Giving single dose then observing ADME
  63. Per se
    by self
  64. Powder
    Fine particles that can result from the comminution of any dry substances
  65. Microneritics
    the study of particle size
  66. Partition Coeficient
    • pg 108
    • Lipid and water soulability
  67. Comminution
    • Grinding a drug in a mortar to reduce its particle size
    • is the process in which solid materials are reduced in size, encompassing crushing, grinding
  68. Gemometirc dilution
    Small amount of potent drugs mixed with other powders
  69. Spatulation
    Blending small amounts of powers by movement of a spatula through them
  70. Tritruation
    Mixing and reduciton of particle size in one size
  71. Sifting
    Fluffy product, mixed by passing thorugh a sifter
  72. tumbling
    the powder in rotating champer
  73. Granule
    Agglomerates of smaller powers, gluing them together
  74. Wet Method
    Blended power + binder agent + sieve of desired mesh + dry at air or oven
  75. Effervesent
    Granules or course powder with effervesent mixture
  76. Drug stability
    Mechanism of degradation
  77. Capsule
    a solid dosag form in which unit dose of powder, semisolid, or liquid drugs are enclosed with
Card Set:
Dose Form Definitions
2011-09-21 03:48:07
Dose form definitions

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