Pharm- Respiratory Sys

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Author:
HLW
ID:
102623
Filename:
Pharm- Respiratory Sys
Updated:
2011-09-18 20:22:11
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Pharm
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Pharm- Respiratory Sys
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  1. Local Antifungals used to Tx Aspergillosis:
    • Enilconzole
    • Clotrimazole
  2. Mechanism of Synthetic imidazoles:
    Affect Fungal Cell Wall
  3. Systemic Tx for Aspirgillosis:
    • Azoles:
    • Ketoconazole
    • Fluconazole
    • Voriconazole
  4. Side Fx od Azoles:
    • Inhibition of CYP450
    • GI
    • Liver Toxicity (Ketocon)
  5. Tx for idiopathic lymphoplasmacytic rhinitis
    Glucocorticoids
  6. Tx for Gutteral Pounch Mycosis (Aspergillus) in horses:
    • Thiobendazole
    • Nystatin
    • Enilconazole
    • Systemic Antifungals
  7. Dx & Tx For Horse w/ Recurrent, Unilateral, Smelly, Nasal Discharge:
    • Sinusitis
    • Sx, Flush with Dilute I
  8. First choice Tx for dog with Bord:
    • Doxy
    • Enrofloxacin
  9. Second choice Tx for dog w/ Bord:
    • Clavamox
    • Tetracycline
  10. Antitussives are useful....
    ...for NON-productive coughs
  11. Anti-tussive Drugs:
    • Opioids:
    • Codeine/Hydrocodone
    • Butorphanol
    • Dextromethorphan
  12. Mechanism of Anti-tussives:
    Suppresses medullary cough center
  13. Which anti-tussive has beneficial Fx in horses?
    Butorphanol
  14. Which Anti-tussive => V and CNS depression?
    Codeine & Hydrocodone
  15. Therapeutic Goals for Bronchitis and LRIs?
    • Treat underlying cause
    • Antimicrobial
    • Tx Symptoms
    • Bronchodilation
    • Increase Secretions
    • Increase mucociliar clearance
  16. What drugs are used to incrase respiratory secretions?
    • Acetylcysteine (breaks bonds)
    • Bromohexine/Bisolvon (Increase water)
    • Dembrexin/Sputolysin (Increase water)
  17. Therapeutic Goals for Treating Asthma/Allergies (7):
    • Decrease Airway Resistance
    • Decrease Inflammatory and Immune Response
    • Stimulate Respiration
    • Supress Cough Reflex
    • Mucolytics
    • Increase Respiratory Secretions
    • Inhibit Repiratory Infections
  18. What type of drugs are used to decrease airway resistance (3)?
    • ACh M3 Antagonists
    • B2-Agonists
    • PDE Inhibitors
  19. What PDE inhibitors are used to Tx asthma/allergies (3):
    • Theophylline (most commonly used)
    • Xanthine
    • Methylxanthine
  20. How does Theophylline work?
    • Inhibits PDE => Increase in cAMP
    • Stimulates Adenosine Receptors => Increase cAMP
    • => Increase Mucociliary Clearance
  21. Side Fx of Theophylline:
    Adrenergic OD (Arrythmias, Agitation, Nervousness)
  22. What Sympathetic Amines are used to Modify Airway Resistence?
    • Adrenaline (activates Sympathetic/Cardiovascular)
    • Isoprenaline
    • Phenylephrine
    • Ephedrine/Pseudoephedrine
  23. After releasing from the receptor, which Drug => Edema and Strong Constriction
    • Ephedrine
    • Pseudoephedrine
  24. What type of drugs are used to Decrease inflammation/immune response in asthma/allergies (4)?
    • Glucocorticoids
    • NSAIDs
    • Mast Cell Stabilizers
    • Anti-Histamines
  25. What type of drugs are used to stimulate Respiration in asthma/allergies (4)?
    • Crotethamide
    • Lobeline
    • Doxapram
    • Etaphylline
  26. What durgs are used as mucolytics w/ Asthma/allergies (4)?
    • N-Acetylcystein
    • Bromhexine
    • Ambroxol
    • Dembrexine
  27. Stimulating Expectorants include (2):
    • Guajacol
    • Guaifenisine
  28. Reflex Expectorants include (2):
    Ammoniumbcarbonate/Chloride
  29. Secretomotorics include (6):
    • Oil of Peppermint
    • Eucalyptus Oil
    • Aniseed Oil
    • Thyme Oil
    • Radix Ipecacuanha
    • oil of terpintine
  30. What group of drugs increase Ca2+ to increase smooth muscle contration?
    AChM3
  31. What anticholinergics are used for special cases of Asthma/Allergies?
    • Atropine
    • Ipratropiumbromide
  32. Uses of Atropine in asthma/allergies:
    • ER Tx
    • Evaluate Responsiveness of COPD
    • (Decreases GI Motility)
  33. With which Asthma/Allergy drugs, is Receptor Down-Regulation & Sperm abnormalities seen?
    B2 Agonists
  34. What drugs are used as Anti-inflammatory's in respiratory conditions?
    • NSAIDs
    • Anti-histamines
    • Doxycycline
    • Glucocorticoids
    • Mast Cell Stabilizers
  35. Which anti-inflammatory drug cannot be used for asthma Ps?
    NSAIDs (aspirine induced asthma)
  36. How do glucocorticoids Tx asthma?
    • Reduce inflammation
    • Stabilize membranes
    • Reduce Mucosal Edema
    • Supress Immune Rxn
    • Sensitize smooth mm to B-Adrenergic Drugs
  37. What are first choice drugs for Tx of R. equi?
    • Gentamycin
    • Lincomycin
    • Rifampin
  38. Expectorants should not be mixed with...
    a-Adrenergics
  39. Airways Resistence can be modfied with:
    • Decongestants
    • Bronchodilators
    • Xanthine

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