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Local Antifungals used to Tx Aspergillosis:
Mechanism of Synthetic imidazoles:
Affect Fungal Cell Wall
Systemic Tx for Aspirgillosis:
Side Fx od Azoles:
- Inhibition of CYP450
- Liver Toxicity (Ketocon)
Tx for idiopathic lymphoplasmacytic rhinitis
Tx for Gutteral Pounch Mycosis (Aspergillus) in horses:
- Systemic Antifungals
Dx & Tx For Horse w/ Recurrent, Unilateral, Smelly, Nasal Discharge:
- Sx, Flush with Dilute I
First choice Tx for dog with Bord:
Second choice Tx for dog w/ Bord:
Antitussives are useful....
...for NON-productive coughs
Mechanism of Anti-tussives:
Suppresses medullary cough center
Which anti-tussive has beneficial Fx in horses?
Which Anti-tussive => V and CNS depression?
Codeine & Hydrocodone
Therapeutic Goals for Bronchitis and LRIs?
- Treat underlying causeAntimicrobial
- Tx Symptoms
- Increase Secretions
- Increase mucociliar clearance
What drugs are used to incrase respiratory secretions?
- Acetylcysteine (breaks bonds)
- Bromohexine/Bisolvon (Increase water)
- Dembrexin/Sputolysin (Increase water)
Therapeutic Goals for Treating Asthma/Allergies (7):
- Decrease Airway Resistance
- Decrease Inflammatory and Immune Response
- Stimulate Respiration
- Supress Cough Reflex
- Increase Respiratory Secretions
- Inhibit Repiratory Infections
What type of drugs are used to decrease airway resistance (3)?
- ACh M3 Antagonists
- PDE Inhibitors
What PDE inhibitors are used to Tx asthma/allergies (3):
- Theophylline (most commonly used)
How does Theophylline work?
- Inhibits PDE => Increase in cAMP
- Stimulates Adenosine Receptors => Increase cAMP
- => Increase Mucociliary Clearance
Side Fx of Theophylline:
Adrenergic OD (Arrythmias, Agitation, Nervousness)
What Sympathetic Amines are used to Modify Airway Resistence?
- Adrenaline (activates Sympathetic/Cardiovascular)
After releasing from the receptor, which Drug => Edema and Strong Constriction
What type of drugs are used to Decrease inflammation/immune response in asthma/allergies (4)?
- Mast Cell Stabilizers
What type of drugs are used to stimulate Respiration in asthma/allergies (4)?
What durgs are used as mucolytics w/ Asthma/allergies (4)?
Stimulating Expectorants include (2):
Reflex Expectorants include (2):
Secretomotorics include (6):
- Oil of Peppermint
- Eucalyptus Oil
- Aniseed Oil
- Thyme Oil
- Radix Ipecacuanha
- oil of terpintine
What group of drugs increase Ca2+ to increase smooth muscle contration?
What anticholinergics are used for special cases of Asthma/Allergies?
Uses of Atropine in asthma/allergies:
- ER Tx
- Evaluate Responsiveness of COPD
- (Decreases GI Motility)
With which Asthma/Allergy drugs, is Receptor Down-Regulation & Sperm abnormalities seen?
What drugs are used as Anti-inflammatory's in respiratory conditions?
- Mast Cell Stabilizers
Which anti-inflammatory drug cannot be used for asthma Ps?
NSAIDs (aspirine induced asthma)
How do glucocorticoids Tx asthma?
- Reduce inflammation
- Stabilize membranes
- Reduce Mucosal Edema
- Supress Immune Rxn
- Sensitize smooth mm to B-Adrenergic Drugs
What are first choice drugs for Tx of R. equi?
Expectorants should not be mixed with...
Airways Resistence can be modfied with: