Card Set Information
mechanism of disease pt2
What are genes?
Basic units of heredity
Changes leads to mutation
Speciic location on chromosome(locus)
in the nucleus occurs in pairs (22 pairs)
23 sex chromosomes
Female XX males XY
Genes are made of nucleic acid
stores genetic info
transfer the genetic info obtain from DNA to proper location for protein synthesis
Making proteins in 2 steps
1. Transcription MRNA is synthesized from single stranded DNA
2. Translation occurs in mrna attached to ribosomes
cell division results info is identical daughter cell
What is active acquired immunity?
invasion of the body by foreign substance(microorganisms)
What is Passive acquired immunity??
host recieves antibodies to an antigen rather than synthesizing them
injection of serum from immune human.
short lived, doesnt retain memory cell
causes immune system to produced antibodies
elicits an immune response
organs parts of the immune response spread easily .
What is the function of lymph nodes
filtration of foreign materials brought to the site
circulation of lymphocytes
What is mononuclear pagocytes
monocytes in the blood and macrophages found throughout the body
they capture, process and present the antigen to the lymphocyte
make antibodies against antigen
antigen presenting cells
b memory cells
bone marrow to the thymus
t cytotoxic cells?
attack antigen on the cell membrane of foreign pathogens and releasing cytolytic substances that destroy the pathogen
2nd exposure may have a more serious response
sensitized remain in the memory
T helper cells
regulation of cell mediated immunity and humoral antibody response.
natural killer cells?
large lymphocytes with numerous granules in the cytoplasm
recognition and killing of virus infected cells, tumor cell, transplanted graft
capture antigenst at the site of contrast and then transport an antigen until it encounter a t cell with specify for the antigen
messanger btwn the cell types
instruct cells to alter their proliferation, differentiation, secretion or activity
stimulate bone marrow to make WBC
antibody mediated immunity
B lymphocytes are involved,
Ex) transfusion reationt, bacterial infection
Cell Mediated Immunity??
immune responses that are initiated through specific antigen recognition by t cells.
T lymphocytes, macrophages, nk cells
ex)tubercolis graft rejection,
sever allergy reaction
brochial constriction/airway obstruction
hypotension, dilated pupils, dyspnea, cyanosis
Atopic reactions -localizes
Type 1 hypersensitivity
provides baby with immunity
only one can cross the placents
Body secretion(line mucous membrane, Breast milk
first one form
Type 2 hypersensitivity
hemolytic transfusion reactions
Goodpasture syndrom (lung/kidney failure)
Immune complex reaction
t/b cells complex
Type 4 hypersensitivity
no antibodies involved