Dose Form Important Test 1

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Author:
ba
ID:
102932
Filename:
Dose Form Important Test 1
Updated:
2011-09-19 22:59:55
Tags:
Dose Form
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Description:
Test 1 important things to know
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  1. Need for dosage form
    • Protection of drug
    • Taste/Odor
    • Appropriate dose
    • Age of patient
    • Rate Controlled Drugs
    • Safety
  2. Preformulation Studies
    • Physical Description
    • Microscopic
    • Melting Point
    • Phase Rule
    • Particle Size
    • Polymorphism
    • Solubility
  3. How to effect the solubiblity of drug
    • pH
    • Particle Size
    • Salt ester forms
  4. How to effect the drug stability
    • Hydrolysis
    • Oxidation
    • Polmerization
    • Decarboxilation
    • Deamination
  5. Enhancement of Stability
    • Hydrolysis
    • Waterproof coating
    • Use substitute liquid, glycerin, oil, alcohol
    • Preparation of suspension, non-aqueous vehicle
    • Dry powder for reconstitution
    • Refrig
    • Buffers, controlling pH
    • Oxidation
    • Antioxidants
    • Light resistant containers (opaque)
    • Buffer controlling pH
  6. Stability Concerned to Pharmacist
    • Chemical
    • Physical
    • Microbological
    • Toxicologic
    • Therapeutic
  7. No color Additives
    • Parential
    • Opthalmic
    • New borns
  8. Drug (the next steps for it to get absorbed)
    • Dissolution into body fluid
    • Transported by body fluid
    • Cross transvers membranes (phospholipid bilayers)
    • Escape unwanted distribution
    • Endure metabolic attack (first pass effect)
    • Penetrate in adequate concentration into sites of action
    • Interact specifically
    • Alteration of cellular funcation
  9. Absorption
    • Disintigration
    • Deaggration
    • Wetting
    • Dissolution
    • Solution

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