FallExam2Drugs

Card Set Information

Author:
Anonymous
ID:
103378
Filename:
FallExam2Drugs
Updated:
2011-09-21 15:51:54
Tags:
FallExam2Drugs
Folders:

Description:
Cancer Chemo
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user Anonymous on FreezingBlue Flashcards. What would you like to do?


  1. DNA Alkylating or Methylating
    • crosslinking btw DNA; modify base in DNA; cytotoxic to dividing/nondividng cells;
    • myelosuppression/alopecia/amenorrhea/male sterility
  2. Mechlorethamine
    • DNA modifying; nitrogen mustards; crosslink DNA; MOPP for Hgk;
    • toxicity-bone marrow/GI
  3. Cyclophosphamide
    • DNA modifying; nitrogen mustards; crosslink DNA;
    • CMF, CVPP for Hgk/NHgk/breast/ovarian;
    • Acrolein-hemorrhagic cystitis, treat with MESNA(acrolein inactivator)
  4. Ifosfamide
    • DNA modifying; nitrogen mustards;
    • same as Cyclophophamide, less toxic,
    • high doses=neurotoxicity
  5. Melphalan
    • DNA modifying; nitrogen mustards; crosslink DNA;
    • multiple myeloma/ovarian cancer;
    • toxicity-nausea/bonemarrow
  6. Carmustine / Lomustine
    • DNA modifying; nitrosoureas; alkylate DNA;
    • brain tumors
    • toxicity-myelosuppression/renal failure; highly lipophilic cross BBB
  7. Busulfan
    • DNA modifying; alkyl sulfonates; crosslinks; Leukemia;
    • toxicity-pulmonary fibrosis, hyperpigmentation
  8. Procarbazine
    • DNA modifying; inhib DNA/RNA/pro syn;
    • MOPP, CVPP for Hgk/NHgk/SCLC/melanoma/brain tumors;
    • toxicity-BM/acetylaldehyde accumulation/monoamine oxidase P450 inhib;
    • no milk/wine/drugs
  9. Dacarbazine
    • DNA modifing; triazens; form toxic methyl carbonium ions;
    • Hgk
    • toxicity-BM/GI/hepatotox
  10. Cisplatin / Carboplatin
    • DNA modifying; platinum complexes; crosslink;
    • testicular (Vinblastine & Bleomycin) Ovarian (cyclophophamide) SC Lung (Etoposide) bladder;
    • toxicity-ototox/nephtox;
    • Carboplatin less toxic, for kidney pt
  11. Methotrexate
    • Antimetabolites; Folic acid analogs; S-phase specific, inhib DHFR-decr thymidylic acid;
    • curative high dose- Choriocarcinoma, Osteogenic carcinoma;
    • ALL/Burkitss/Breast/NHgk/head/neck/bladder; CMF;
    • decree RA/psoriasis; tox-BM/GI/renal/hepatic fibrosis/nephrotox
    • Leucovorin reduces toxicity; resistance-incr/altered DHFR
  12. Leucovorin
    • Antimetabolites; Folate antagonist rescue agent;
    • reduces methotrexate toxicity
  13. 6-Mercaptopurine (6-MP)
    • Antimetabolites; Purine analogs; S-phase specific HGPRT;
    • ALL/ AML;
    • tox-BM/hyperuricemia; allopurinal incr 6-MP toxicity
  14. 6-Thioguanine (6-TG)
    • Antimetabolites; Purine analogs;
    • AML (cytarabine and Daunorubicin);
    • toxicity-BM/hyperuricemia
  15. 5-Fluorouracil (5-FU)
    • Antimetabolites; Pyrimidine analogs; S-phase specific inhib tymidylate synthase;
    • CMF-breast, FAM-colon;
    • Toxicity-myelosuppression/GI; cimetidine-heartburn drug higher survival rate;
    • Cisplatin/Leucovorin/Methotrexate modulate activity
  16. Capecitabine
    • Antimetabolites; Pyrimidine analogs; 5-FU prodrug;
    • colon/breast
  17. Cytarabine (AraC)
    • Antimetabolites; Pyrimidine analogs; becomes Ara CTP which incorporates and terminates DNA elongation;
    • AML (6-TG)
    • tox-myelosuppression
  18. Gemcitabine
    • Antimetabolites; Pyrimidine analogs; Not S-phase specific,inhib DNA pol;
    • pancreatic/NSCLC
    • toxcity-myelosupppression/flu-like/incr liver enzyme
  19. Vinblastine
    • Natural products; Phase Specific; Vinca Alkaloids; bind tubulin;
    • testicular (Bleomycin, Cisplatin)
    • ABVD-Hgk/NHgk/Choriocarcinoma
    • toxicity-BM
  20. Vincristine
    • Natural products; Phase Specific; Vinca Alkaloids; bind tubulin;
    • ALL, MOPP-Hgk, NHgk, solid tumors;
    • Toxicity-peripheral neuropathy
  21. Paclitaxel / Docetaxel
    • Natural products; Phase Specific; Taxanes; M-phase specific, promotes MT formation;
    • metastatic ovarian/breast;
    • toxicity-hypersensitivity (tx-dexamethasome, diphenhydramine) Neurtopenia (tx-GCS-F)
  22. Etoposide
    • Natural products; Phase Specific; Podophyllotoxins; inhib Topoisomerase II;
    • testicular tumors (Bleomycin, Cisplatin) SC carcinoma lung (Cisplatin, Ifosfamide), NHgK/Leuk/Kaposi
    • toxicity-myelosuppression
  23. Topotecan
    • Natural products; Phase Specific; Camptothecins; inhib Topoisomerase I;
    • metastatic ovarian/SCLC;
    • toxicity-diarrhea/BM/alopecia/naus/bronzing;
    • UGT1A1, bilirubin detox enzyme->l low level WBC
  24. Irinotecan
    • Natural products; Phase Specific; Camptothecins; inhib Topoisomerase I;
    • Colorectal Cancer;
    • toxicity-diarrhea/BM/alopecia/naus/bronzing;
    • UGT1A1, bilirubin detox enzyme->l low level WBC
  25. Bleomycin
    • Natural products; Phase Specific; G2-phase specific, binds DNA;
    • testicular carcinomas (Cisplatin, Vinblastine, Etoposide) squamous cell carcinoma, lymphoma;
    • toxicity-phneumonitis/pulmonary fibrosis/hyperpigmentation
  26. Actinomycin D (Doxorubicin)
    • Natural products; DNA-binding antibiotics;
    • Wilm's Tumor, Rhabdomyosarcoma (vincristine, cyclosphosphamide);
    • toxicity-myelosuppression/GI
  27. Adriamycin
    • Natural products; DNA-binding antibiotics; Anthracyclines; intercalate with DNA;
    • ABVD, FAM for myelomas/sarcomas/lymphomas
    • toxicity-cardiotoxicity
  28. Daunorubicin
    • Natural products; DNA-binding antibiotics; Anthracyclines; intercalate with DNA;
    • AML, ALL;
    • toxicity-cardiotoxicity
  29. Epirubicin
    • Natural products; DNA-binding antibiotics; Anthracyclines; intercalate with DNA;
    • CEF for breast (more effective than CMF in premenopausal)
    • toxicity-cardiotoxicity
  30. Hydroxyurea
    • Misc Antineoplastic Agent; S-phase specific, inhib ribonucleoside diphosphate reductase;
    • leukemias
    • toxicity-myelosuppression
  31. L-asparaginase
    • Misc Antineoplastic Agent; deprives cell of asparagine, effects protein syn;
    • ALL (Vincristine, Prednisone)
    • toxicity-hypersensitivity/hyperglycemia/coag defects/hypboalbuminemia
  32. Thalidomide
    • Misc Antineoplastic Agent; stimulates T and NK cells, inhib angiogenesis;
    • multiple myelomas;
    • toxicity-sedation/constipation
  33. Vorinostat
    • Misc Antineoplastic Agent; HDAC inhib, apop;
    • Tcell lymphomas;
    • toxicity-fatigue/diarrhea/ nausea/anorexia/thrombocytopenia/PE
  34. Bortezomib
    • Misc Antineoplastic Agent; proteasome inhibitor; 26Sproteosome inhib;
    • multiple myeloma;
    • toxicity-nausea/diarrhea/weak muscles/BM/fever/anorexia
  35. Imatinib mesylate
    • Misc Antineoplastic Agent; Protein Tyrosine Kinase Inhibitor; binds Bcr-Abl kinase;
    • CML
    • toxicity-nausea/muscle cramps/neutropenia/thrombocytopenia;
    • competitive inhib of CYP3Y, 2C9, 2D6 so give Rx that aslo inhib->incr [imatinib]
  36. Getfitinib / Erlotinib
    • Misc Antineoplastic Agent; Protein Tyrosine Kinase Inhibitor; inhib EGFR;
    • NSCLC
    • toxicity-fatique, well-tolerated; polymorphs in EGFR correlate with drug efficacy;
    • P450 inducers -> decr [Getfitinib]
  37. Sunitinib
    • Misc Antineoplastic Agent; Protein Tyrosine Kinase Inhibitor; inhib VEGFR, PDGFR;
    • advanced renal cell carcinoma, Gi stromal tumors;
    • toxicity-fatigue, well tolerated
    • metab by CYP3A4
  38. Sorafenib
    Misc Antineoplastic Agent; Protein Tyrosine Kinase Inhibitor
  39. Lapatinib
    • Misc Antineoplastic Agent; Protein Tyrosine Kinase Inhibitor; EGFR, HER2 kinase blockers;
    • ER+ breast cancer (letrozole/capecitabin);
    • toxicity-fatigue, rash;
  40. Trastuzumab
    • Misc Antineoplastic Agent; Monocolonal Ab; blocks HER2/neu R;
    • metastatic breast cancer w/ amplified HER2;
    • toxicity-cardiotox with Adriamycin;
    • doesn't cross BBB
  41. Rituximab
    • Misc Antineoplastic Agent; Monocolonal Ab; binds CD20 on Bcells, cause lysis;
    • low-grade B cell NHgk;
    • toxicity-fever/chills/nausea on first infusion
  42. Cetuximab
    • Misc Antineoplastic Agent; Monocolonal Ab; Binds EGFR;
    • colon cancer;
    • toxicity-acne like rash
  43. Interferon-alfa
    • Misc Antineoplastic Agent; Biological Response Modifiers; activate sin of 2'5'oligoadenylate synthase, proto-onc, decr c-myc, inhib port sin, activate nuclease;
    • hairy cell leukemia/Kaposi/malignant melanoma;
    • toxicity-fever/chills/myelosup/neurotox
  44. Tamoxifen
    • Hormonal Agents; Selective Estrogen Receptor Modulators; competitive inhib of estradiol, suppress growth, decree TGF IGF-1;
    • advanced ER= breast cancer
    • toxicity-hot flashes/vaginal bleeding/skin rashes/hypercalcemia/endometrial cancer risk
    • resistance-decr affinity to receptor;
    • Pro-estrogen on bone, lipids, uterus ->slow osteoporosis, decree cholesterol
  45. Aminoglutethimide
    • Hormonal Agents; Aromatase Inhibitors; reduces estradiol levels;
    • metastatic breast cancer (glucocorticoid);
    • toxicity-CNS depression/drowsiness/visual blurring/ataxia
  46. Anastrozole
    • Hormonal Agentst; Aromatase Inhibitors;
    • advanced breast cancer in post-menop;
    • toxicity-GI/myalgia/headache/bone/back reduced blood clots than tamoxifen
  47. Leuprolide / Goserelin
    • Hormonal Agentst; long-acting gonadotropin releasing, hormone analogs; continuously inhib FSH and LF;
    • MOPP, CVPP,
    • ALL/CLL/Hgk/NHgk/breast;
    • toxicity-Cushing's/immunosuppression
  48. Flutamide
    • Hormonal Agents; Antiandrogens; blocks DHT binding to Androgen receptor;
    • prostate cancer;
    • toxicity-GI
  49. MOPP
    • Mechlorethamine, Oncovin, Prednisone, Procarbazine;
    • Hgk
  50. CVPP
    • Cyclophosphamide, Vincristine, Prednisone, Procarbazine;
    • NHgk
  51. CMF
    • Cyclophosphamide, Methotrexate, 5-fluorouracil;
    • ER-Breast
  52. ABVD
    • Adriamycin, Bleomycin, Vinblastine, Dacarbazine;
    • Lymphomas and Sarcomas
  53. FAM
    • 5-Fluorouracil, Adriamycin, Mitomysin;
    • Colon
  54. CMV
    Cisplatin, Methotrexate, Vinblastine
  55. FAC
    5-Flurouracil, Adriamycin, Cyclophophamide

What would you like to do?

Home > Flashcards > Print Preview