9/13 Protein Structure
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AA Linked by peptide bonds
Primary Structure of Proteins
Secondary Structure of Proteins contain what
Hemoglobin is what type of protein?
The Amino Acid Sequence of a protein is referred to as its
Each protein has a unique AA structure determined by what
determine 3D shape
Molecular Pathology --> Cancer
Why is it important to know the structure of proteins/amaino acid sequence of proteins?
Sickle Cell Anemia
2 Examples of single AA substitutions
constitutively active AKA
Unregulated cell growth --> Cancer
if an enzyme is constitutively active what happens
Mutation of Glu6 to Val in hemoglobin
Which enzyme mutation cx Sickle Cell Anemia
What are the 2 main secondary structures?
Coil and Turn
beta sheets and polypeptide segments without a distinctly folded arrangement are called
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