9/13 Protein Structure

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AA Linked by peptide bonds

Disulfide Bonds

Primary Structure of Proteins
Alpha Helix

Secondary Structure of Proteins contain what
Quaternary Structure

Hemoglobin is what type of protein?
Alpha Helix

Folded Protein

Teritary Structure
primary structure

The Amino Acid Sequence of a protein is referred to as its
DNA (Genes)

Each protein has a unique AA structure determined by what
determin MOA

determine 3D shape

Molecular Pathology --> Cancer

Why is it important to know the structure of proteins/amaino acid sequence of proteins?
Sickle Cell Anemia

Cancer

2 Examples of single AA substitutions
Always On

constitutively active AKA
Unregulated cell growth --> Cancer

if an enzyme is constitutively active what happens
Mutation of Glu6 to Val in hemoglobin

Which enzyme mutation cx Sickle Cell Anemia
Alpha Helixes

Beta Helixes

What are the 2 main secondary structures?
Coil and Turn

beta sheets and polypeptide segments without a distinctly folded arrangement are called