Bacterial Toxins

Card Set Information

Author:
skycloud
ID:
103713
Filename:
Bacterial Toxins
Updated:
2011-09-25 15:44:12
Tags:
toxins bacteria
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Description:
Different toxins by bacteria that frequently have them
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  1. Diphtheria toxin
    • Corynebacteria diphtheriae
    • ADP riposyl transferase
    • inactivates EF-2
    • Targets: heart, nerves, epithelium
  2. Exotoxin A
    • Pseudomonas aeruginosa
    • ADP ribosyl transferase
    • inactivates EF-2
    • Target: liver
  3. Shiga toxin
    • Shigella dysenteriae
    • binds 60s subunit
    • enterotoxic, cytotoxic, neurotoxic
    • bloody diarrhea
  4. Verotoxin (shiga like)
    • Enterohemorrhagic E. coli
    • binds 60s subunit
  5. Tetanus toxin
    • Clostridium tetani
    • blocks release of glycine and GABA
    • spastic paralysis
  6. Botulism toxin
    • Clostridium botulinum
    • blocks release of ach
    • flaccid paralysis
  7. TSST-1
    • Staph aureus
    • induces IL-1, IL-6, TNF-a, IFN-g
    • decreases liver clearance of LPS
    • fever, rash, shock, cardiotoxicity
  8. Exotoxin A (strep)
    AKA erythrogenic toxin
    AKA pyrogenic toxin
    • Strep pyogenes
    • induces inflammatory factor release
    • fever, rash, LPS sensitivity, cardiotoxicity
  9. Heat labile toxin (LT)
    • Enterotoxigenic E. coli
    • ADP ribosylates GTP binding protein
    • stimulates adenylate cyclase
    • secretory diarrhea
  10. Cholera toxin
    • Vibrio cholera
    • ADP ribosylates GTP binding protein
    • stimulates adenylate cyclase
    • secretory diarrhea
  11. Anthrax toxin
    • Bacillus anthracis
    • EF = edema factor = adenylate cyclase
    • LF = lethal factor
    • PA = protective antigen (B component)
    • decreases phagocytosis
    • edema, cytotoxicity
  12. Pertussis toxin
    • Bordetella pertussis
    • ADP ribosylates Gi
    • adenylate cyclase free from inhibition
    • histamine sensitization
    • lymphocytosis (inhibits chemokine receptors)
    • islet activation
  13. Alpha toxin
    • Clostridium perfringens
    • lecithinase
    • damages cell membranes
    • myonecrosis
  14. Alpha toxin (pore)
    • Staph aureus
    • forms pores in membrane
    • cell lysis
  15. EF-2 inhibitors
    • Diphtheria toxin
    • Exotoxin A
  16. 60s subunit binders
    • shiga toxin
    • verotoxin
  17. Neurotoxins
    • tetanis toxin
    • botulinum toxin
  18. Superantigens
    • TSST-1
    • Exotoxin A (pyrogenic)
  19. cAMP inducers
    • LT
    • Cholera toxin
    • Anthrax toxin
    • Pertussis toxin
  20. Cytolysins
    • Alpha toxin
    • Alpha toxin (pore)

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