Virulence and diagnostic factors

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Author:
skycloud
ID:
103817
Filename:
Virulence and diagnostic factors
Updated:
2011-09-23 10:38:31
Tags:
bacteria virulence capsule
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Description:
Factors contributing to virulence or otherwise helping to identify bacteria
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  1. Attachment to host cells
    All gram + have it
    Lipoteichoic acid
  2. Antiphagocytic polysaccharide
    • Capsule
    • Salmonella typhi, Neisseria meningitides, Klebsiella pneumoniae, Haemophilus influenzae, Strep pneumoniae, Cryptococcus neoformans, Pseudomonas aeruginosa
  3. Binds Fc of IgG
    Inhibits phagocytosis
    • A protein
    • Staph aureus
  4. Antiphagocytic
    • M protein
    • Group A strep
  5. Attachment structures
    • Pili
    • Mostly on gram -
  6. Antiphagocytic
    Antigenic variation
    Pili of Neisseria gonorrheae
  7. Hydrolysis of ground substance
    • Hyaluronidase
    • Group A strep
  8. Hydrolysis of collagen
    • Collagenase
    • C. perfringens
    • prevotella melaninogenica
  9. Increases pH of micro-environment
    Contributes to kidney stones
    • Urease
    • PUNCH
    • Proteus, Ureaplasma, Nocardia, Cryptococcus, Helicobacter
  10. Hydrolysis of fibrin
    • Kinases
    • Strep, Staph
  11. Destroys cell membranes
    • Lecithinase (alpha toxin)
    • Clostridium perfringens
  12. Thrombophlebitis
    • Heparinase
    • Bacteroides
  13. Detoxifies hydrogen peroxide
    • Catalasea
    • Staph, Pseudomonas, Aspergillus, Candida, Enterobacteria
  14. Destroys IgA
    • IgA protease
    • Promotes colonization of mucosal surface
    • Neisseria, Haemophilus, Strep pneumo
  15. Detoxifies oxygen radicals
    • Oxidase
    • Involves cytochrome C
    • Neisseria
    • Most gram - except Enterobacteria
  16. Promotes fibrin clot
    • Coagulase
    • Staph aureus
    • Yersinia pestis

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