Pharm Prototype Ch 17

• Therapeutic: Drug to restore peristalsis or treat urinary retention
• Pharmacologic: Cholinergic agonist, muscarinic agonist (direct acting)

• Stimulated smooth muscle contraction. Restore smooth muscle tone and peristalisis following general anesthesia. Relaxes urinary sphincters and causes detrusor muslce of the bladder to contract (resulting in voiding)
• Off label: treatment of adynamic ilius and gastric atony

interacts indirectly with muscarinic receptors to cause body responses typical of parasympathetic stimulation. It is not destroyed by AchE; therefore, its actions are more prolonged than those of Ach.

• Route(s): PO, subcut
• Absorption: Poorly absorbed PO, well absorbed subcut
• Distribution: Widely distributed; does not cross the blood brain barrier
• Primary metabolism: Unknown
• Primary excretion: renal
• Onset of Action: PO: 30 min; subcut 5-15 min
• Duration of action: PO: 1-6 h; subcut: 2h