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blierman
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What are the Therapeutic and Pharmacologic Classifications fo Bethanechol chloride (Duvoid, Urecholine)?
- Therapeutic: Drug to restore peristalsis or treat urinary retention
- Pharmacologic: Cholinergic agonist, muscarinic agonist (direct acting)
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What are the Therapeutic Effects of Bethanechol chloride (Duvoid, Urecholine)?
- Stimulated smooth muscle contraction. Restore smooth muscle tone and peristalisis following general anesthesia. Relaxes urinary sphincters and causes detrusor muslce of the bladder to contract (resulting in voiding)
- Off label: treatment of adynamic ilius and gastric atony
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What is the mechanism of action of bethanechol chlordie (Duvoid, Urecholine)?
interacts indirectly with muscarinic receptors to cause body responses typical of parasympathetic stimulation. It is not destroyed by AchE; therefore, its actions are more prolonged than those of Ach.
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What are the Pharmacokinetics of bethanechol chloride (Duvoid, Urecholine)?
- Route(s): PO, subcut
- Absorption: Poorly absorbed PO, well absorbed subcut
- Distribution: Widely distributed; does not cross the blood brain barrier
- Primary metabolism: Unknown
- Primary excretion: renal
- Onset of Action: PO: 30 min; subcut 5-15 min
- Duration of action: PO: 1-6 h; subcut: 2h
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