Pharm L17, T2 Cholinergic antagonist.txt

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  1. What is another name for anti-cholinergic drugs?
    Anti-muscarinic drugs
  2. Most common ending for cholinergic antagonist drugs?
    -in or -ine b/c of atropine relation
  3. What is the prototype for cholinergic antagonist?
    Atropine: inhibits Ach binding receptor
  4. What happens to the eye when treated with Atropine?
    • M3 receptor blocked
    • miosis inhibited = mydriasis instead
    • no accomodation to near vision (ciliary muscles can't contract)
  5. Along w/ Atropine, what is another main M antagonist?
  6. Scopolamine:group, function, side effects
    • group: cholinergic antagonists
    • function: motion sickness help
    • side effect: sedation, short term memory loss, hallucinations
  7. Scopolamine vs. Atropine: CNS, skin absorption
    • CNS
    • Scopolamine absorbed easily
    • Atropine absorbed only at high doses
    • Skin
    • S = easily absorbed, good for patches = motion sickness
  8. Homatropine/Tropicamide: duration and function
    • duration: short
    • function: mydriasis
    • side effect: increased intraocular pressure, narrow angled glaucoma
  9. Ipratropium/Tiotropium: group, function, side effect
    • group: cholinergic antagonist
    • Function: asthma, COPD relief
    • side effect: no CNS effects!!
  10. Tolterodine: group, subgroup, function
    • group: M3 selective Choline antagonist
    • subgroup: opioids
    • function: overactive bladder treatment or after prostate surgery
  11. What is combined w/ atropine for diarrhea relief?
    opiods (e.g. Tolterodine, the "dine" is an example of an opiod)
  12. Atropine dose effect rule?
    • low: salivary, sweat glands, bronchioles
    • high: heart, eye, GI, urinary tract
    • very high: CNS entrance = hallucinations, etc...
  13. Scopolamine toxicity?
    • **due to high CNS affects
    • hallucinations
    • agitation
    • coma
  14. Benztropine effects and disease use
    • effects: restore balance b/t DA/Ache when DA low or receptors blocked in CNS
    • disease: Parkinson's disease use
  15. M antagonist most commonly used in Opthamology due to 6 hr duration?
  16. Cardiac effects of M antagonist?
    • Decreased vagal tone = Tachycardia
    • increased NE b/c of presynaptic M2 receptor
  17. Why do M antagonists have little or no effect on BVs?
    BVs are under control by Beta and Alpha receptors (B = dilate, A = constrict)
  18. What is the complication with giving M antagonists to men w/ benign prostatic hyperplasia?
    It causes urinary retention
  19. What happens to secretions when M antagonists are administered?
    • **Decrease**
    • sweat
    • lacrimation
    • urination
    • defectation
  20. T/F intraocular pressure increases with M antagonist administration?
  21. What is the result of Atropine combined w/ diphenoxylate?
    stop diarrhea
  22. Dicyclomine function
  23. Two uses of Atropine in the heart?
    • Decrease bradycardia (cause tachycardia)
    • Reverse heart block
  24. Glycopyrrolate: group, function
    • group: cholinergic antagonist
    • function: Prevent vagal reflexes during surgery
  25. Five drugs used for overactive bladder, urinary incontinence?
    • Tolterodine: M3 selective
    • Fesoterodine: M3 selective
    • Darifenacin, Solifenacin: M3 selective
    • Oxybutynin: prevent bladder spasm after prostate surgery
  26. dicyclomine: group, function
    • group: Cholinergic antagonist
    • function: GI antispasmodic
  27. Oxybutynin & Trospium: group, function
    • group:Cholinergic antagnoists
    • function: Inhibit bladder spasms after surgery
  28. What type of glaucoma is caused b/c of cholinergic antagonists?
    • Narrow angled glaucoma
    • * causes trapping of aqueous humor and increased intraocular pressure
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Pharm L17, T2 Cholinergic antagonist.txt
Pharm L17, T2 Cholinergic antagonist
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