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What is another name for anti-cholinergic drugs?
Most common ending for cholinergic antagonist drugs?
-in or -ine b/c of atropine relation
What is the prototype for cholinergic antagonist?
Atropine: inhibits Ach binding receptor
What happens to the eye when treated with Atropine?
- M3 receptor blocked
- miosis inhibited = mydriasis instead
- no accomodation to near vision (ciliary muscles can't contract)
Along w/ Atropine, what is another main M antagonist?
Scopolamine:group, function, side effects
- group: cholinergic antagonists
- function: motion sickness help
- side effect: sedation, short term memory loss, hallucinations
Scopolamine vs. Atropine: CNS, skin absorption
- CNSScopolamine absorbed easily
- Atropine absorbed only at high doses
- SkinS = easily absorbed, good for patches = motion sickness
Homatropine/Tropicamide: duration and function
- duration: short
- function: mydriasis
- side effect: increased intraocular pressure, narrow angled glaucoma
Ipratropium/Tiotropium: group, function, side effect
- group: cholinergic antagonist
- Function: asthma, COPD relief
- side effect: no CNS effects!!
Tolterodine: group, subgroup, function
- group: M3 selective Choline antagonist
- subgroup: opioids
- function: overactive bladder treatment or after prostate surgery
What is combined w/ atropine for diarrhea relief?
opiods (e.g. Tolterodine, the "dine" is an example of an opiod)
Atropine dose effect rule?
- low: salivary, sweat glands, bronchioles
- high: heart, eye, GI, urinary tract
- very high: CNS entrance = hallucinations, etc...
- **due to high CNS affects
Benztropine effects and disease use
- effects: restore balance b/t DA/Ache when DA low or receptors blocked in CNS
- disease: Parkinson's disease use
M antagonist most commonly used in Opthamology due to 6 hr duration?
Cardiac effects of M antagonist?
- Decreased vagal tone = Tachycardia
- increased NE b/c of presynaptic M2 receptor
Why do M antagonists have little or no effect on BVs?
BVs are under control by Beta and Alpha receptors (B = dilate, A = constrict)
What is the complication with giving M antagonists to men w/ benign prostatic hyperplasia?
It causes urinary retention
What happens to secretions when M antagonists are administered?
T/F intraocular pressure increases with M antagonist administration?
What is the result of Atropine combined w/ diphenoxylate?
Two uses of Atropine in the heart?
- Decrease bradycardia (cause tachycardia)
- Reverse heart block
Glycopyrrolate: group, function
- group: cholinergic antagonist
- function: Prevent vagal reflexes during surgery
Five drugs used for overactive bladder, urinary incontinence?
- Tolterodine: M3 selective
- Fesoterodine: M3 selective
- Darifenacin, Solifenacin: M3 selective
- Oxybutynin: prevent bladder spasm after prostate surgery
dicyclomine: group, function
- group: Cholinergic antagonist
- function: GI antispasmodic
Oxybutynin & Trospium: group, function
- group:Cholinergic antagnoists
- function: Inhibit bladder spasms after surgery
What type of glaucoma is caused b/c of cholinergic antagonists?
- Narrow angled glaucoma
- * causes trapping of aqueous humor and increased intraocular pressure