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What are the SSRI's and how do they work?
- Celexa, Lexapro, Paxil, Prozac, Zoloft
- -works by blocking the reuptake of serotonin
Name the tricyclic antidepressants and how they work?
- Pamelor, Elavil, Doxepin, Tofranil
- -works by blocking norepi and to a lesser degree, serotonin
What are the SNRI's and how do they work?
- Cymbalta, Effexor, Remeron, Trazodone, Wellbutrin
- -They block the reuptake of norepi and serotonin
What are your MAOI's and how do they work?
- Nardil, Parnate
- -they work by inhibiting MAO in the presynaptic cell thereby preventing the destruction of neurotransmitters therefore increasing the amount available for use
What are your antianxiety/benzo's and how do they work?
- Ativan, Klonopin, Valium, Xanax
- -work by enhancing GABA receptors by binding to the adjacent benzodiazepine receptors and allowing GABA to inhibit the CNS more forcefully
This antianxiety med is not a benzo and has an unknown action but does have a high affinity for serotonin receptors. It is not addictive, with no sedative properties
What are your Standard/Typical antipsychotics and how do they work?
- Thorazine,Haldol, Prolixin
- -these work by blocking dopamine receptors in pts with Schizophrenia and Tourette's
What are your atypical antipsychotics and how do they work?
- Abilify, Clozaril, Geodon,Riserdol, Seroquel, Zyprexa
- -works by blocking serotonin and dopamine receptors (serotonin-dopamine antagonists) They affect the negative and positive sides of Schizophrenia
What class is Lithium in and what is it used for?
Mood stabilizer used for bipolar
What is some teaching about lithium that we need to address to our pts?
- -Maintain sodium intake (about 2g) don't raise or lower your usual intake.
- -drink the usual 6-8 glasses of water/day
- -Take c food
- -restrict caffeine
- -fine hand tremors are expected
- -dysrythmias & seizures may occur
- -keep appts for frequent lab value levels
What are the therapeutic lab values as well as a toxic value?
- therapeutic= 0.6/1.2
- toxic= 1.5 or greater
What are your mood stabilizers/anticonvulsants and how do they work?
- Depakote, Lamictal, Neurontin, Tegretol, Topramax
- They increase GABA in the brain therefore decreasing mania in bipolar pts
What is Dopamine responsible for in our bodies?
- Stimulation of heart and blood flow to other visceral organs
- fine muscle movement
- emotions and thoughts
- decision making
What is Norepi responsible for in our bodies?
- attention and arousal
- stimulates sympathetic nervous system (fight or flight) in response to stress
If someone presents in the state of mania, what neurotransmitter would you expect to see increased in the brain?
If someone presents with psychosis, what neurotransmitter would you expect to see evelvated in the brain?
What conditions would you present with if you had a decrease in serotonin?
How about an increase?
What is histamine responsible for?
- Inflammaotry response
- stimulates gastric secretions
What is the function of acetylcholine?
- Plays a role in learning and memory
- regulated mood:mania, sexual aggression
- stimulates parasympathetic nervous system (rest and digest)
In a person with Alzheimer's and Parkinson's disease, what neurotransmitter would be affected and how?
Acetylcholine would be decreased
What is the function of GABA?
- Reduces anxiety, excitation, & aggression
- anticonvulsant and muscle-relaxing properties
If you have mania, anxiety, or schizophrenia, would you expect your GABA to be increased or decreased in your brain?