Microbial Drugs

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Author:
lazzsant
ID:
105286
Filename:
Microbial Drugs
Updated:
2011-09-29 23:09:18
Tags:
Pharm
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Description:
Intro to antimicrobial drugs
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  1. Penicillin
    • Beta-lactams
    • Cell wall synthesis inhibitor
    • Site: Cell Wall
    • Action: inhibition of transpeptidases
  2. Cephalosporins
    • Beta-lactams
    • Cell wall synthesis inhibitor
    • Site: Cell Wall
    • Action: inhibition of transpeptidases
  3. Carbapenems
    • Beta-lactams
    • Cell wall synthesis inhibitor
    • Site: Cell Wall
    • Action: inhibition of transpeptidases
  4. Monobactams
    • Beta lactams
    • Cell wall synthesis inhibitor
    • Site: Cell Wall
    • Action: inhibition of transpeptidases
  5. Vancomycin
    • Cell wall synthesis inhibitor
    • Site: Cell Wall
    • Action: Inhibition of transglycosylase
  6. Fosfomycin
    • Cell wall synthesis inhibitor
    • Site: Cell Wall
    • Action: Inhibition of enolpyruvate transferase
  7. Aminoglycosides
    • Protein synthesis inhibitors
    • Site: Ribosome (30S)
    • Action: Blockade of the "initiation complex"
    • - Misreading of the code of mRNA template
    • - Blockade of translocation reaction
  8. Macrolides & Ketolides
    • Protein synthesis inhibitors
    • Site: Ribosome (50S)
    • Action: Blockade of translocation reaction
  9. Clindamycin
    Protein synthesis inhibitors
  10. Tetracyclines & glycylcycline
    • Protein synthesis inhibit
    • Site: Ribosome (30S)
    • Action: Blockade of aminoacyl-tRNA binding
  11. Streptogramins
    Protein synthesis inhibitors
  12. Chloramphenicol
    • Protein synthesis inhibitors
    • Site: Ribosome(50S)
    • Action: Block transpeptidation reaction
  13. Linezolid
    • Protein synthesis inhibitors
    • Site: Ribosome(50S)
    • Action: Blockade of the "initiation complex"
  14. Sulfonamides
    • Inhibitors of nucleic acid synthesis or function
    • Site: Cytoplasm
    • Action: Inhibition of dihydropteroate synthetase
  15. Trimethoprim
    • Inhibitors of nucleic acid synthesis or function
    • Site: cytoplasm
    • Action: inhibition of dihydrofolate reductase
  16. Fluoroquinolones
    • Inhibitors of nucleic acid synthesis or function
    • Antimycobacterial *
    • Site: cytoplasm
    • Action: Inhibition of topoisomerases
  17. Metronidazole
    • Inhibitors of nucleic acid synthesis or function
    • Site: DNA
    • Action: DNA damage
  18. Isoniazid
    Antimycobacterial
  19. Rifampin
    Antimycobacterial
  20. Pyrazinamide
    Antimycobacterial
  21. Ethambutol
    Antimycobacterial
  22. Streptomycin
    Antimycobacterial
  23. Quinupristin
    • Protein synthesis inhibitor
    • Site: Ribosome(50S)
    • Blockade of translocation reaction
  24. Dalfopristin
    • Protein synthesis inhibitor
    • Site: Ribosome(50S)
    • Action: Induction in conformational change in the 50S ribosome
  25. Two Mechanisms
    1) Binds penicillin-binding proteins and inhibits catalytic functions of these enzymes.
    2) Activate autolysins
    Time dependent bactericidal
    Beta- Lactams
  26. Bind terminus of nascent peptidoglycan pentapeptide --> inhibition of transglycosylase
    Bactericidal
    Vancomycin
  27. Inhibits enolpyruvate transferase --> blocks N-acetylmuramic acid synthesis.
    Fosfomycin
  28. Inhibits the binding of the tRNA to the (A) site of the ribosome.
    tetracyclines
  29. Inhibits the transpeptidation reaction of peptidyltransferase
    Chloramphenicol
  30. Inhibits translocation reaction to the (P) site.
    (4 drugs)
    • 1) aminoglycosides
    • 2) macrolides
    • 3) lincosamides
    • 4) type B streptogramins

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