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Main disease association w/ cystic medial degeneration?
Marfan's syndrome: Elastic problem
What cells do I-CAM & V-CAM adhere?
What causes stasis and swelling of the LE b/c of lack of mobility?
What is the main cause of primary HTN?
renal retention of excess sodium = high BP
What is the first step in atherogenesis?
Endothelial cell damage
What disease is present with red streaks in arm, swollen lymph nodes in axillary region, and recent onset?
Along with entering Macrophages and forming foam cells, what are two other jobs of oxidized LDL in plaque formation?
Monocyte chemotaxis and adherence
T/F fattys streaks cause disturbances in BF?
F, they are a precursor of T-cells and monocytes. No epithelial changes have been made.
What condition is complicated by cellulitis after mastectomy w/ lymph nodes?
First cell on sight to start forming atherosclerosis?
What vasculitis that can lead to blindness?
Giant cell (temporal) arteritis: large, medium arteries of head, vertebral column and eyes
which test is best for a predicter of atherosclerosis?
What is Anasarca?
- Severe generalized edema
- * from nephrotic syndrome, liver disease, heart disease, shock
Primary and secondary causes of lymphedema?
- Primary: Millroy disease
- Secondary: Trauma, surgery, etc...
What occurs in the lungs after a left ventricular failure after MI?
venous congestion of capillary beds and increased hydrostatic pressure which causes release of transudate into alveolar space
Function of VwFactor?
adhere recruited plateletes to one another to initially stop bleeding and help with cascade start
what is the major cause for pulmonary thromboembolism?
What genetic defect is most common and present in pts with common deep venous thrombosis issues?
Factor V Leidin deficiency
Main function of Antithrombin III?
Inhibit thrombin to force more prothrombin time and slow down clotting
What is the most common cause of arterial thrombosis?
vascular endothelial damage
Principle molecule released from Dense granules of platelets?
If an organ were to be spared from ischemic injury, which organ and why?
Liver b/c of dual blood supply
Common complication of Bioprosthetic valve?
Stenosis or insufficiency
What -itises are a result of rheumatic fever?
pancarditis w/ endocarditis (vegetations), myocarditis (aschoff bodies), and pericarditis
Name the four Pericarditis diseases and their associated disease outcomes?
- 1) Serous = inflammation
- 2) fibrinous = friction rubs & adhesions
- 3) Prurulet = mediastinopericarditis, cosntructive pericarditis
- 4) Caseous = chronic costructive pericarditis
T/F Vasculitis often involve cardiac valves
What cardiomyopathy grows a more hypertrophied septum than ventricular wall?
Hypertrophic cardiomyopathy, diastolic disease
What two diseases most often form hermorrhagic pericarditis?
TB & metastatic carcinoma
What is the most important complication following a coronary thrombosis?
At what pulse do you find bradycardia and tachycardia?
- Bradycardia >100/min
- Tachycardia <60/min
What is the pacemaker node of the heart?
What is a main cause of LV hypertrophy and pulmonary edema?
What is the most common explanation of sudden unexplained death in young athletes?
T/F HTN causes aortic stenosis?
F, it only causes LV hypertrophy
What side of the heart does myocardial infarction generally affect?
L, but then this damage can lead to R. Heart damage
What type of pericarditis does SLE generally cause?
Rheumatic fever will cause vegetations and stenosis of what two valves?
Mitral & aortic
A Patent Foramen Ovale is associated with what septal defect?
What septal defect is associated with Down's syndrome?
What types of heart defects are associated with DiGeorge syndrome 22q11.2 deletion?
R-L shunts (Tetralogy, truncus arteriosus, hypoparathyroidism)
What heart disease is Williams syndrome associated with?
Hypoplastic Left Heart syndrome
Signs of Williams syndrome?
- Supravalvular stenosis
- Elastin gene gone
- Facial abnomalies (long mouth, pointed chin, epicanthial folds present, strabismus, etc...)
Two most common causes of hemorrhagic pericardial effusion?
tumor & TB
What is the role of the NOTCH gene?
modulation of vascular development (lack = cardiac issues like tetralogy of fallot)
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