351 Antidepressant Drugs

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351 Antidepressant Drugs
2011-09-30 22:18:07
351 Antidepressant Drugs

351 Antidepressant Drugs
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  1. What is Citalopram (Celexa)
    • -SSRI
    • -First line agent
    • -Side effects: Mostly Sexual dysfunction and GI effects
    • -Works with R and S isomer
  2. What is Escitalopram (Lexapro)?
    • -SSRI
    • -First line agent
    • -Better side effect profile: mostly GI Effects
    • -Can be used for GAD
  3. What is Fluoxetine (Prozac, Sarafem)?
    • -SSRI
    • -First line agent
    • -Side effects: Insomnia, Sexual dysfunction, GI effects
    • -Can be used for bulimia, premenstrual dysphoric disorder, pain management and promoting smoking cessation
  4. What is Fluoxetine/Olanzapine (Symbyax)?
    • -SSRI
    • -Unique combo for those with bipolar and depression
    • -Only drug approved for acute treatment-resistand depression
    • -Side effects: sexual dysfunction, weight gain, hyperglycemia, and high cholesterol
  5. What is Fluvoxamine (Luvox)?
    • -SSRI
    • -First line agent
    • -Approved for OCD.
    • -Side effects: similar to other SSRIs
  6. What is Paroxetine (Paxil, Paxil CR, Pexeva)?
    • -Potent SSRI
    • -First line agent
    • - Common side effect: nausea, causes sexual side effects, GI effects
    • -May be teratogenic.
    • -Given a once daily basis
  7. What is Sertraline (Zoloft)?
    • -SSRI
    • -Given once daily with or without food.
    • -Side effects: sexual dysfunction, usually returns to normal after 2-3 days and GI effects
  8. What is Bupropion (Wellbutrin, Aplenzin)?
    • -Novel, NDRI
    • -Only one with dopamine reuptake inhibition and does not affect serotonin systems
    • -Good side effect profile, mostly insomnia
    • -Do not give with drugs that increase dopamine
    • -Off sets SSRI mediated sexual inhibition
    • -Do not give with seizure disorders!
    • -Can be used as a smoking cessation agent
  9. What is Venlafaxine (effexor)?
    • -Novel, SNRI
    • -At lower doses causes serotonin to be enhanced, at medium to high doses NE reuptake is inhibited, and at high doses dopamine levels are increased
    • -Few side effects, other than high blood pressure
  10. What is Duloxetine (Cymbalta)?
    • -Novel, SNRI
    • -Acts like Venlafaxine (Effexor)
    • -Good side effects, mostly nausea
    • -Approved for diabetic neuropathic pain
  11. What is Trazodone (desyrel)?
    • -Novel
    • -Prescribed for sleep, side effect sedation
    • -Adverse reaction-priapism, if this happens patient should stop medication and call prescriber
  12. What is Mirtazapine (Remeron)?
    • -Novel, alpha 2 antagonist with 5 HT2 and 5 HT3.
    • -Approved for Major depression
    • -Increase NE and serotonin
    • -An increase in serum cholesterol level occurs
    • -Side effect profile good, sedation is high
    • -Dissolvable tablet available
  13. What is Amitriptyline (Elavil)?
    • -TCA
    • -Highly anticholinergic and one of the most sedating and cardiotoxic antidepressants
    • -Side effects: orthostatic hypotension common
  14. What is Amoxapine (Asendin)?
    • -TCA
    • -Metabolite of antipsychotic drug loxapine
    • -Beneficial for psychotic and depressed patients
    • -Side effects such as EPSE and TD
  15. What is Desipramine (Norpramin)?
    • -TCA
    • -Metabolite of imipramine
    • -Activating antidepressant so good for apathetic, lethargic, and hypersomnic patients
    • -Most toxic TCA
    • -Does have certain effects on the heart so use with care when dealing with certain age groups
  16. What is Imipramine (Tofranil)?
    • -TCA
    • -Anticholinergic properties, sedating and causes sexual dysfunction
    • -Proven effective in treating childhood enuresis, however use care with child
  17. What is Nortriptyline (Aventyl, Pamelor)?
    • -TCA
    • -Sedating but other than that has a good side effect profile
    • -Least toxic TCA
    • -Often prescribed for older adult patients who are depressed, agitated and suffering from insomnia
  18. What is Phenelzine (Nardil)?
  19. What is Tranylcypromise (Parnate)?
    • -MAOI
    • -Side effects: Insomnia, anticholinergic, orthostatic hypotension
  20. What is Moclomemide (Menerix)?
    • -MAOI, inhibits only MAO-A
    • -Side effects: Sexual dysfunction, insomnia, orthostatic hypotension
  21. What is Seligiline (Emsam)?
    • -MAOI
    • -Anticholinergic and orthostatic hypotension as side effects
  22. What are serious side effects of SSRIs?
    • -Energizing effect on suicide risk (happens 2 weeks after patient starts taking drug)
    • -Serotonin syndrome (Overdose of serotonin, Shivering most common side effect that can be seen!)
    • -Withdrawal syndrome
    • -Avoid St John Wort and MAOI
  23. What are serious side effects of Novel antidepressants?
    • -Energizing effect on suicide risk
    • -Priapism (Desyrel)
    • -Seizures (Wellbutrin)
  24. What are serious side effects of TCA?
    • -Energizing effect on suicide risk
    • -Cardiac arrhythmias
    • -Very lethal only give 7 day supply
    • -Do not mix with alcohol, MAOI, OTC stimulates, antihypertensive
  25. What are serious side effects of MAOIs?
    • -Energizing effect on suicide risk
    • -Hypertensive Crisis
    • -Has many food-drug (avoid tyramine) interactions and drug-drug interactions