Path, Disturbances of Growth
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Growth rate usually corresponds to...
degree of differentiation
- Transformation of one adult cell type to another of the same germ layer
- (epithelium and CT)
Characterizations of neoplasia (5):
- Growth w/o control
- No orderly arrangement
- No function
- Resemble originating cells
- No etiology
Malignant implies (2):
- Ability to invade locally and destroy
Term used to describe tumor cells that don't resemble parent tissue (undifferentiated):
Two benign tumors that grow rapidly:
- Canine oral Papilloma
- Canine Hormone Dep Mammary Tumors
Metastasis occurs via:
- Blood Vascular Sys
- Lymphatic System
- Body Cavities
- Along Epithelium
- Along Duct Systems
What tumors spread via body cavities (Serous Mem) (5)?
- Splenic Hemangiosarcoma
- Gastric Carcinoma
- Pulmonary Tumors
What tumor spreads along epithelium (1)?
- Mammary Carcinoma
- -> Inguinal region
Tumors that spread along Duct Systems (3)?
- Mammary Gland Tumors
- Testicular Tumors
- Renal Pelvic Tumors
Angiogenesis VS Hemangiosarcoma
- Angiogenesis= New BV Formation
- Hemangiosarcoma= Tumor in BV endothelium
Targets for Genetic Damage:
- Cancer Suppressor Genes
- Proteins that Regulate apoptosis
Oncogenes are derived from...
- Growth Factors
- Signaling molecules
- Cell Cycle Regulators
What controls normal cell proliferation/inhibit growth?
Cancer Supressor Genes
- DFTD (Devil Facial Tumor)
- (fel. sarcoma, FeLV, BoLV, Avian leukosarcosis)
What tumors secrete Ca?
- Anal Sac Adenoma
- Multiple Myeloma (Plasma Cell Tumor)
- (Dogs only)
What tumors induce hypoglycemia?
- Insulinoma in dogs
- (+/- hepatocellular carc., hepatoma, mammary, pulmonary carc., salivary carc, leuiomyoma)
- (Mostly only dogs)
Term used to describe systemic complications of neoplasia that are remote from the primary tumor:
Paraneoplastic Syndroms Affect...(5)
- Metabolism (Hypercalcemia & Hypoglycemia)
- Constituents of Circulation
Tumors affecting bones
Hypertrophic (pulmonary) Osteopathy, HO
Location of SCC's in...
- Dogs: Skin
- Cats: Skin
- Cattle: Eye & Vulva
- Horses: Eye lid & Penis
Tumor often seen in nail bed epithelium of dogs
Upon histologic exam, what => round holes w/ homogenous pink staining?
Benign neoplasm, caused by viruses and is not found in cats:
Upon histological exam => Non homogenous center surrounded by CT
Most common tumor associated with...
- bovine= Papilloma
- equine= SCC
Common skin tumors in many species, except dogs
Most common skin tumor in cats & +/- dogs
Feline Fibrosarcoma is caused by...
- Feline Sarcoma Virus
- Vaccine Associated Fibrosarcomas
Which is more common, fibroma or fibrosarcoma?
What tumor arises in the mesentary of horses & is fatal due to strangulation of the bowel? *
Histiocytomas originate where?
- Langerhan's cells
- (Cutanoues MO)
Benign tumor that grows rapidly and forms a "button"
Tumor often found in Grey Horses
- Melanomas & Melanocytomas
- (Peri-anal & Perineal)
Tumor frequently found in dogs. Start in skin and metasises to regional LN
Mast Cell Tumor
What tumor causes edema of the limbs, puritic papillocrustus lesions and lymphadenopathy in cats?
Cutaneous Mast Cells Tumor
___ is the most common site for neoplasia in cats, & ___ is the most common type of neoplasia
In contrast to other species, no viral etiology has been found for ____ in dogs
Forms of lymphosarcomas:
What tumor does not spare any tissues in cattle?
Lymphosarcoma, Enzootic Leukosis
What causes Hyper calcemia in dogs, bone lysis and M Protein in BM & urine?
Multiple Myeloma (Plasma Cell Tumor)
Location of Hemangiosarcoma in...
- Dogs: Sleen
- Cats: Skin & Spleen
Mammary tumors most often occur in which glands?
Two Caudal Glands
Frequency of Malignant Mammary Gland tumors in (vs benign)...
What time of tumor is Canine Mammary Tumor?
In cats, mammary hyperplasias can be differentiated from mammary tumors based on...
- Young cats
- Acute onset
Where do Anal gland adenomas/adenocarcinomas arise from?
Perianal Gland tumor?
- AG: Aprocrine/Sweat Glands
- Perianal: Modified Sebaceous Glands (Hair glands)
AG Adenomas secrete...
Paratharmone => Hypercalcemia
What tumor is morphologically similiar to liver and is 90% benign?
Perianal Gland Tumor
Three testicular neoplasms:
- Sertoli Cell Carcinoma
- Interstitial Cell Tumor
Which Testicular Tumor is most common in dogs?
Sertoli Cell Tumors
Which testicular tumor causes feminization & bone marrow depression?
Sertoli Cell Tumors (++ Estrogen)
Benign tumor that causes nymphomania/masculinization in cows & mares
Granulosa Cell Tumor (ovary)
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