Path, Disturbances of Growth

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  1. Growth rate usually corresponds to...
    degree of differentiation
  2. Metaplasia:
    • Transformation of one adult cell type to another of the same germ layer
    • (epithelium and CT)
  3. Characterizations of neoplasia (5):
    • Growth w/o control
    • No orderly arrangement
    • No function
    • Resemble originating cells
    • No etiology
  4. Malignant implies (2):
    • Ability to invade locally and destroy
    • Metastasis
  5. Term used to describe tumor cells that don't resemble parent tissue (undifferentiated):
  6. Increased Anaplasia=>
    Increased malignancy
  7. Two benign tumors that grow rapidly:
    • Canine oral Papilloma
    • Canine Hormone Dep Mammary Tumors
  8. Metastasis occurs via:
    • Blood Vascular Sys
    • Lymphatic System
    • Body Cavities
    • Along Epithelium
    • Along Duct Systems
  9. What tumors spread via body cavities (Serous Mem) (5)?
    • Splenic Hemangiosarcoma
    • Ovarian
    • Intestinal
    • Gastric Carcinoma
    • Pulmonary Tumors
  10. What tumor spreads along epithelium (1)?
    • Mammary Carcinoma
    • -> Inguinal region
  11. Tumors that spread along Duct Systems (3)?
    • Mammary Gland Tumors
    • Testicular Tumors
    • Renal Pelvic Tumors
  12. Angiogenesis VS Hemangiosarcoma
    • Angiogenesis= New BV Formation
    • Hemangiosarcoma= Tumor in BV endothelium
  13. Targets for Genetic Damage:
    • Protooncogenes
    • Cancer Suppressor Genes
    • Proteins that Regulate apoptosis
  14. Oncogenes are derived from...
  15. Protooncogenes regulate:
    • Growth Factors
    • Signaling molecules
    • Cell Cycle Regulators
  16. What controls normal cell proliferation/inhibit growth?
    Cancer Supressor Genes
  17. Contagious cancers:
    • DFTD (Devil Facial Tumor)
    • TVT
  18. Carcinogenic Viruses:
    • Papilloma
    • Myxo
    • Adeno
    • Herpes
    • Retrovirus
    • (fel. sarcoma, FeLV, BoLV, Avian leukosarcosis)
  19. What tumors secrete Ca?
    • Anal Sac Adenoma
    • Lymphosarcoma
    • Multiple Myeloma (Plasma Cell Tumor)
    • (Dogs only)
  20. What tumors induce hypoglycemia?
    • Insulinoma in dogs
    • (+/- hepatocellular carc., hepatoma, mammary, pulmonary carc., salivary carc, leuiomyoma)
    • (Mostly only dogs)
  21. Term used to describe systemic complications of neoplasia that are remote from the primary tumor:
    Paraneoplastic Syndroms
  22. Paraneoplastic Syndroms Affect...(5)
    • Metabolism (Hypercalcemia & Hypoglycemia)
    • Bones
    • Constituents of Circulation
    • Neurologic
    • Skin
  23. Tumors affecting bones
    Hypertrophic (pulmonary) Osteopathy, HO
  24. Location of SCC's in...
    • Dogs: Skin
    • Cats: Skin
    • Cattle: Eye & Vulva
    • Horses: Eye lid & Penis
  25. Tumor often seen in nail bed epithelium of dogs
    Sugungual SCC
  26. Upon histologic exam, what => round holes w/ homogenous pink staining?
  27. Benign neoplasm, caused by viruses and is not found in cats:
  28. Upon histological exam => Non homogenous center surrounded by CT
  29. Most common tumor associated with...
    Bovine Penis=
    Equine Penis=
    • bovine= Papilloma
    • equine= SCC
  30. Common skin tumors in many species, except dogs
  31. Most common skin tumor in cats & +/- dogs
  32. Feline Fibrosarcoma is caused by...
    • FeLV
    • Feline Sarcoma Virus
    • Inflammation/Trauma
    • Vaccine Associated Fibrosarcomas
  33. Which is more common, fibroma or fibrosarcoma?
  34. What tumor arises in the mesentary of horses & is fatal due to strangulation of the bowel? *
  35. Histiocytomas originate where?
    • Langerhan's cells
    • (Cutanoues MO)
  36. Benign tumor that grows rapidly and forms a "button"
  37. Sticker Sarcoma=
  38. Tumor often found in Grey Horses
    • Melanomas & Melanocytomas
    • (Peri-anal & Perineal)
  39. Tumor frequently found in dogs. Start in skin and metasises to regional LN
    Mast Cell Tumor
  40. What tumor causes edema of the limbs, puritic papillocrustus lesions and lymphadenopathy in cats?
    Cutaneous Mast Cells Tumor
  41. ___ is the most common site for neoplasia in cats, & ___ is the most common type of neoplasia
    • Spleen
    • Mast Cell Tumor
  42. In contrast to other species, no viral etiology has been found for ____ in dogs
  43. Forms of lymphosarcomas:
    • Multicentric
    • Alimentry
    • Mediastinal
  44. What tumor does not spare any tissues in cattle?
    Lymphosarcoma, Enzootic Leukosis
  45. What causes Hyper calcemia in dogs, bone lysis and M Protein in BM & urine?
    Multiple Myeloma (Plasma Cell Tumor)
  46. Location of Hemangiosarcoma in...
    • Dogs: Sleen
    • Cats: Skin & Spleen
  47. Mammary tumors most often occur in which glands?
    Two Caudal Glands
  48. Frequency of Malignant Mammary Gland tumors in (vs benign)...
    • Dogs: 50%
    • Cats: 90%
  49. What time of tumor is Canine Mammary Tumor?
  50. In cats, mammary hyperplasias can be differentiated from mammary tumors based on...
    • Hyperplasia=
    • Young cats
    • Acute onset
  51. Where do Anal gland adenomas/adenocarcinomas arise from?
    Perianal Gland tumor?
    • AG: Aprocrine/Sweat Glands
    • Perianal: Modified Sebaceous Glands (Hair glands)
  52. AG Adenomas secrete...
    Paratharmone => Hypercalcemia
  53. What tumor is morphologically similiar to liver and is 90% benign?
    Perianal Gland Tumor
  54. Three testicular neoplasms:
    • Sertoli Cell Carcinoma
    • Seminoma
    • Interstitial Cell Tumor
  55. Which Testicular Tumor is most common in dogs?
    Sertoli Cell Tumors
  56. Which testicular tumor causes feminization & bone marrow depression?
    Sertoli Cell Tumors (++ Estrogen)
  57. Benign tumor that causes nymphomania/masculinization in cows & mares
    Granulosa Cell Tumor (ovary)
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Path, Disturbances of Growth
Path, Disturbances of Growth
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