Progestogens

Card Set Information

Author:
kvan4741
ID:
105981
Filename:
Progestogens
Updated:
2011-10-03 06:01:56
Tags:
OCP contraceptives progestogen activity
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Description:
Differential activity of various progestogens in OCP
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  1. levonorgestrel, norethisterone
    • lower risk of VTE
    • listed on PBS
    • widely used
    • Levonorgestrel (100mcg):
    • Loette, microgynon, microlevlen, monofeme, nordette
    • triphasic: logynon, trifeme, triphasil, triquilar
    • Norethisterone (150mcg):
    • brevinor, norimin
    • triphasic: improvil, synphasic
  2. gestodene, desogestrel
    • less androgenic activity
    • double risk of VTE vs. levonorgestrel and norethisterone
    • gestodene (75mcg): femoden, minulet
    • desogestrel (150mcg): marvelon
  3. dienogest
    • anti-androgenic activity (approx 1/3 of cyproterone)
    • beneficial effects on acne
    • valette - 2mg, Qliara - 2mg/3mg
  4. drospirenone
    • related to spironolactone, anti-mineralocorticoid (mild diuretic and K+ retention) and anti-androgenic activity
    • slightly higher risk of VTE than levonorgestrel
    • Yaz, yasmin - 3mg
  5. cyproterone
    • progestogenic and anti-androgenic
    • tx for androgenisation (severe acne, idiopathic hirsutism)
    • higher incidence of VTE
    • brenda-35, juliet-35, estelle-35, diane-35, laila-35 - 2mg

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