pharm T3, L1 neoplasm.txt
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pharm T3, L1 neoplasm.txt
pharm T3 L1 neoplasm
pharm T3, L1 neoplasm
How many cells are needed for a neoplasm to arise?
1 = clonal
proper term for malignant cancers?
cells that determine the organ or cell produced
general coonetive tissue and BV of new growths
T/F There is stroma in soft, fleshy tumors
Three tumor causes? (HEN)
Two locations and types of benign tumors that will kill just b/c of their location?
Meningioma = brain
Myxoma = heart
glands including liver and kidney
cystic mass lined from neoplastic glandular cells
growths above skin or mucosal surface, neoplastic or non-neoplastic (inflammation)
Carcinomas (malignant) of basal cells or adnexa (hair, sweat glands)
Basal cell carcinoma
Carcinoma of duct or columnar cell origin?
What are the two epithelial tumors from placenta?
Hydatidiform mole = benign
Choriocarcinoma = malignant
What are the two most common
germ cell carcinomas
, common in testicular tumor?
Seminoma (dysgerminoma in females) = estes
Teratoma origin? benign? Mature
Totipotent origin, from all three germ cell layers
mature teratoma, cystic variety frome ectoderm
benign tumor of mesenchyme w/ mucoid appearance
** most common tumor of heats in adults
T/F There are benign hematopoietic neoplasms?
Two hematopoietic neoplasms?
Three Nervous system neoplasms
Pieces of one mature tissue present w/i another, developmental anomaly
pancreas, gastric tissue (meckel's diverticulum), lingual thyroid, endometriosis, lacrimal gland tissue in conjunctiva
T/F Endometriosis outside of uterine cavity is a developmental anomaly
F, the only one of the Heterotopias that is not developmental
Choristoma? 4 Locations?
: One or more mature tissues come together to form tumor mass at random site
conjunctiva, cartilage, Sm mm, lacrimal gl
-focal malformation of a mixture of tissues that are native to that area
Malignant change in cell
4 steps for the malignancy of a tumor cell?
how close a neoplastic cell resembles comparable normal cells
(e.g. benign cells are indistinguishable)
Lack of differentiation, malignant characteristic
disordered growth, precancer
What is the largest life-compatible tumor?
1kg = 10 doublings from 1g
how many cells are proliferating
-measure by S-phase
What is the origin of cancer?
more aggressive behavior = more malignant potential
** occurs b/c of multiple mutations
pop. of cells that differ with respect to phenotype
synonym for invasion meaning direct invasion of adjacent tissue or organ
Tumor implant discontinuous w/ primary tumor
Two malignancies that do not metastasize?
glioma = brain
basal cell carcinoma = skin
What are the three pathways of metastasis?
Blood borne (hematogenesis)
What is the most important determinant of prognosis for most cancers?
Stage: how far the tumor has spread
breaks through to an open field and spreads onto surfaces of space
ovarian, gastric/pancreatic, intestinal, lung, CNS, urinary tract
Lymphatic spread examples?
Carcinoma and some sarcomas
oral (cervical nodes), breast (axillary), lung (perihilar), colon (paracolic)
What procedure is peformed if carcinoma has entered lymph travel?
sentinel node biopsy
Removal of closest node to cancer = less likely to form lymphedema
** usually venous, arterial mainly from lungs