Micro T2, L32.txt

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Author:
kepling
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106112
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Micro T2, L32.txt
Updated:
2011-10-05 13:29:54
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Micro T2 L32
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Micro T2, L32
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  1. Three risk factors for TB?
    • DM
    • Silicosis
    • Immunosuppression
  2. What is the cord factor of TB?
    • Virulence factor
    • ** Mycoside: 2 MAs + 1 disaccharide
  3. T/F M. tb has no glyococalyx or toxins
    T, just pure number and inhibition of immune system
  4. 5 risk factors for infection from M. tuberculosis?
    • Contact
    • Long-term care facility
    • low income
    • alcohol consumption
    • malnutrition
  5. What are the three outcomes of M. tuberculosis infection?
    • 1) clearance
    • 2) Granuloma formation to wall off bacteria
    • 3) no granuloma = hematogenous miliary TB
  6. What type of pathogen is M. tuberculosis?
    Facultative intracellular pathogen
  7. What type of necrosis is caused from M. tuberculosis infection?
    Caseous
  8. How many weeks does a TB infection need to be present to activate a skin test?
    2-6 wks
  9. What type of lung environment is best for latent TB infections?
    • low pH
    • low O2
  10. What is the most important cause of secondary TB?
    HIV
  11. What is miliary TB?
    The caseous necrosis w/i granuloma not contained and the lesion is lysed so spread occurs
  12. What is Potts disease?
    MTB in vertebral bodies
  13. Four components of TB ID?
    • skin test
    • medical history
    • X-ray
    • Bacterial ID
  14. What type of hypersensitivity rxn is the skin test?
    Type IV, CMI activation
  15. T/F the skin test can activate primary TB
    F, just secondary (latent)
  16. T/F the + skin test implies active immunity and disease
    F, does not imply active infection or immunity
  17. What is the stain for AF bacteria like M. tuberculosis?
    • Ziehl-Neelsen
    • Turant Fluorescent (preferred by labs)
  18. What is the BACTEC system and its four related antibiotics?
    • Bacterial ID test in 6-10 days
    • RISE: rifampin, isoniazind, streptomycin, ethambutol
  19. What is the best way to manage treatment of TB?
    DOT: Direct Observation of Treatment
  20. What drug is commonly used in single drug therapy of TB?
    INH
  21. What are the first line drugs (RISE-P-?
    • Rifampin
    • Isoniazid
    • Streptomycin
    • Ethambutol
    • Pyrazinamide
  22. What is the common vaccine for TB?
    BCG (can cause False positive)

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