NURS1921 Exam III: Pharmacology

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JARoberts
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106178
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NURS1921 Exam III: Pharmacology
Updated:
2011-10-03 21:13:42
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NURS1921 Exam III Pharmacology
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Based on lecture by Ms. Buchholz
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  1. Mr. James is in a state of starvation. He has a very low serum (blood) albumin level. Albumin is one of the major proteins in the blood. His condition would MOSTLY interfere with which of the following processes of drug activity?
    Distribution: Some drugs combine with proteins while being transported in the blood, and albumin is one of the major blood proteins. Therefore, a low serum albumin level would interfere with drug distribution.
  2. Your patient is in shock, which causes the capillaries (small blood vessels) to constrict. This, in turn, slows down blood flow. You give the patient an intramuscular injection of a drug. What would you anticipate?
    • Absorption would be impaired: A good blood flow at the site of drug administration enhances absorption. If blood flow is impaired, the absorption process will be
    • impaired.
  3. A frequently used narcotic analgesic is codeine sulfate. When you administer this drug to patients, you anticipate they will have relief from pain but also may experience constipation. Your anticipation is based MOSTLY on which principle?
    Drugs have multiple actions rather than a single action: The fact that codeine relieves pain but also causes constipation is based on the principle that drugs generally have more than one action or effect on individuals.
  4. Your patient is in shock, which causes the capillaries (small blood vessels) to constrict. This, in turn, slows down blood flow. You give the patient an intramuscular injection of a drug. Which of the following would you anticipate?

    a. drug absorption would be enhanced
    b. drug absorption would be enhanced
    b. drug absorption would be enhanced: A good blood flow at the site of drug administration enhances absorption. If blood flow is impaired, the absorption process will be impaired.
  5. If given orally, some drugs are partially metabolized by the liver before they reach the general circulatory system. This is due to:

    A. a prolonged half-life.
    B. the first-pass effect.
    C. the drug molecules having difficulty crossing over the blood-brain barrier.
    D. the absorption time being equal to the elimination time.
    B. the first-pass effect: Drug molecules absorbed from the GI tract go through the portal circulation before entering the general circulation. In the liver, the drug molecules may be metabolized and deactivated. This is called the first-pass effect.
    (this multiple choice question has been scrambled)
  6. Simon Hurst has chronic obstructive pulmonary disease (COPD). If he were given a gas as a general anesthesia, he would probably have the MOST difficulty with the drug's:

    A. distribution.
    B. metabolism.
    C. excretion.
    C. excretion: A gas given as a general anesthesia is excreted from the body via the lungs.
    (this multiple choice question has been scrambled)
  7. Because infants have immature liver enzyme systems, they will have difficulty with drug:

    A. metabolism.
    B. elimination.
    C. excretion.
    D. absorption.
    A. metabolism: Drugs are mainly metabolized in the liver. Infants with immature liver enzyme systems will have difficulty with this process.
    (this multiple choice question has been scrambled)

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