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Name the three ways that pneumonia bacteria enter the body?
What are the four common atypical CAP bacteria?
- Legionella pneumophila
- Mycoplasma pneumoniae
- Chlamydia trachomatis
- Chlamydophila pneumoniae
Of the four CAP bacteria, which is most commonly found?
What helps opsonize L. Pneumophila?
How does L. Pneumophila infect host?
- Inhibits phagolysosome
- Lyses phagosome & releases toxins
Two diseases caused by L. Pneumophila?
- 1) Pontiac fever: self-limited illness
- 2) Legionnaires' Disease: sever, atypical pneumonia = 75% mortality from shock or resp. failure
What cell does Legionnaires' Disease infiltrate?
T/F immunity to L. pneumophila is long lasting?
T, through CMI system
Gold standard for L. pnemophila testing?
What Titer demonstrates infection w/ L. pneumophila?
IFA of 128, still must be 4-fold increase
DOC for L. pneumophila?
T/F M. Pneumoniae are resistant to cell-wall inhibitors
T, b/c they do not have cell walls
What is the special culture appearance of M. pneumoniae
What CAP bacteria most commonly causes atypical CAP?
What is specifically found in the plasma membrane of M. pneumoniae?
T/F infection w/ M. pneumoniae causes long lasting immunity?
How does M. pneumoniae infiltrate the lungs?
Binds to ciliated epithelium by P1 adhesins, releases H2O2 + O2 = ciliostasis and damage
Two tests used to ID M. pneumoniae and how they work?
- Elisa: >32 or 4-fold increase
- Cold agglutination assay: detect IgM binding to I antigen on RBCs
DOC for M. pneumoniae?
Where are chlamydial bacteria found?
T/F Chlamydial bacteria have peptidoglycan layer and LPS since they are G -?
F, they do not have peptidoglycan layer but do have LPS
What is the pathogenesis of Chlamydial disease?
Direct cell destruction & inflammation
T/F Chlamydial bacterial infection immunity is not long lasting?
Primary defense against chlamydial infection?
How is chlamydia trachomatis transferred?
Transfer: mother to infant at birth
Main disease caused by C. Trachomatis?
main child symptoms w/ C. trachomatis?
- staccato cough
Main disease caused by C. pneumoniae?
Bronchitis, atypical pneumonia, sinusitis
How is respiratory disease of Chlamydia detected?
- 1) Microimmunofluorescent assay for IgM/IgG
- IgM >16
- IgG > 512
- 4-fold increase
- 2) Microscope: intracellular inclusions
DOC for Chlamydia treatment?