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What are the the three types of orthomyxovirus and which is most potent?
Exampel of orthomyxovirus that causes influenza??
Why is Type A orthomyxovirus (influenza) so dangerous?
It can easily and frequenlty change genome
What are the two methods utilized by Type A influenza to change genome?
- antigenic drift: pt mutations of H or N proteins = vaccinations
- antigenic shift: complete genome recombination of H & N proteins = pandemic
What is the incubation period and persistent period of influenza
- Incubation: 1-2 days
- Persistence: 1 wk
When is the flu dangerous?
After it has left and another fever comes on. That is a sign of another infection.
What bacteria take advantage of the immunocompromised state of a person w/ influenza?
- S. pneumoniae
- S. aureus
- H. influenza type B (HiB)
What two complications arise as a result of Influenza?
- Reyes syndrome
- Guillain-Barre syndrome
What is Reyes syndrome? What age affected? Cause?
- edematous encephalitis
- Fatty alteration of liver
- Age: 6 mo. -15 yr
- cause: Influenza A/B
What is the effect of Aspirin combined with chicken pox?
What is Guillain-Barre syndrome?
de-myelination of peripheral nerves
T/f Influenza is a nosocomial infection?
Function of Amantadine & Rimantadine?
- Antibiotic treatment for Influenza Type A
- - M2 protein inhibitor
- - Stops uncoating/penetration
Function of Zanamivir & Oseltamivir?
- Influenza A & B ab
- block neuraminidase
- prevent sialic acid cleavage
How long does a doctor have to administer a drug against influenza?
What are the three components of an influenza vaccine?
two A's and one B
Three forms of influenza vaccine?
- 1) Whole
- 2) Split
- 3) surface antigen
T/F FluMist (live attenuated) should not be given to immunocompromised or old people?
What year saw the highest death rate in young adults due to the flu?