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T/F MAC can grow intracellularly like TB?
T/F MAC cannot be killed by disinfection/chlorination?
T, resistant to both
After macrophage infection, where do MAC pulmonary infections go?
Submucosa to Lymphatics
Three forms of MAC?
- Pulmonary (PMAC)
- Dissimenated (DMAC)
What is fibrocavitary disease?
- MAC disease of upper lobe
- common in male smokers
What is fibronodular disease?
- fastidious, female smoker
- lingual or middle lobe infected
- "Lady Windermere's disease"
Common age group for Lymphadenitis?
what is the most common MAC disease? symptoms?
- DMAC: AIDS patients
- upper right quadrant
T/F granulomas can easily contain MAC diseases?
F, therefore hematogenous spread occurs (liver, bone marrow, spleen = blood bound)
What is HAART?
Highly active antiretroviral therapy (used for AIDS patients to increase CD4)
Diff in reporting MAC vs. MTB?
- MAC = no report unless AIDS related
- MTB = always report
Three treatment methods for MAC?
- Combination therapy
What is the combination therapy for MAC?
Macrolides + Ethambutol + Rifampin
What is the target CD4 level during treatment?
> 100 cell/microliter
What is the main method of spread for Nocardia?
Aerosolization (wind, dust, etc...)
T/F Nocardia can become a Nosocomial infection?
T/F Nocardia is opportunistic
What two diseases are most susceptible to Nocardia?
- T-cell deficiency
- Chronic pulmonary disease
What are the three dangerous signs of Nocardia?
- Spread to pleura
- Brain abscess
DOC for Nocardia infectino?
Order of treatment?
IV then oral