quiz 3 - Phar 605

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VASUpharm14
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quiz 3 - Phar 605
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2011-10-09 11:46:38
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quiz 3 top 41-60 let's do this!
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  1. Cipro
    generic?
    ciprofloxacin hydrochloride
  2. Cipro
    class?
    fluoroquinolone antibiotic
  3. Cipro
    MOA?
    prevents the synthesis of bacterial DNA by interfering with the enzyme DNA gyrase. Wide range of activity against Gram-negative and Gram-positive bacteria.
  4. Cipro
    dosage form?
    • Tablets (IR)
    • Oral Suspension
    • Injection
  5. Cipro XR
    generic?
    ciprofloxacin hydrochloride
  6. Cipro XR
    class?
    fluoroquinolone antibiotic
  7. Cipro XR
    MOA?
    prevents the synthesis of bacterial DNA by interfering with the enzyme DNA gyrase. Wide range of activity against Gram-negative and Gram-positive bacteria
  8. Cipro XR
    dosage form?
    • Tablets (extended)
    • Oral Suspension
    • Injection
  9. Tylenol with Codeine
    generic?
    acetaminophen with codeine
  10. Tylenol with Codeine
    class?
    opioid analgesic
  11. Tylenol with Codeine
    MOA?
    • acetaminophen - inhibiting prostaglandin synthesis in the CNS and through a peripheral action by blocking pain impulse generation
    • codeine phosphate - centrally via action on the central opiate receptors
  12. Tylenol with Codeine
    dosage form?
    • Tablets (No. 2, 3, 4)
    • Elixir (schedule C-V)
  13. Phenaphen with Codeine
    generic?
    acetaminophen with codeine
  14. Phenaphen with Codeine
    class?
    opioid analgesic
  15. Phenaphen with Codeine
    MOA?
    • acetaminophen - inhibiting prostaglandin synthesis in the CNS and through a peripheral action by blocking pain impulse generation
    • codeine phosphate - centrally via action on the central opiate receptors
  16. Phenaphen with Codeine
    dosage form?
    • Tablets (No. 2, 3, 4)
    • Elixer (schedule C-V)
  17. Fosamax
    generic?
    alendronate sodium
  18. Fosamax
    class?
    osteoporosis agent
  19. Fosamax
    MOA?
    • alendronate - adheres to sites of bone resorption inhibiting osteoclast activity. Normal bone formed on top of alendronate and incorporated into bone matrix. Then is not pharmacologically active - must repeat process. Net effect is bone formation > bone resorption
    • Vitamin D - for normal bone function and involved in the dietary absorption of calcium and phoshate.
  20. Fosamax
    dosage form?
    • Tablets
    • Oral solution
    • Fosamax plus D
  21. Crestor
    generic?
    rosuvastatin calcium
  22. Crestor
    class?
    antihyperlipidemic
  23. Crestor
    MOA?
    selective competitive inhibitor of HMG-CoA reductase (HMG-CoA --> mevalonate --> cholesterol). Increases the number of LDL receptors on the surface cell --> increase uptake and catabolism of LDL and inhibits the hepatic synthesis of VLDL. Reduces total cholesterol, LDL-C, apo B, VLDL-C, and triglycerides and produce variable increases in HDL and apo A-1
  24. Crestor
    dosage form?
    Tablets (5, 10, 20, 40 mg)
  25. Elavil
    generic?
    amitriptyline hydrochloride
  26. Elavil
    class?
    antidepressant
  27. Elavil
    MOA?
    inhibits the membrane pump mechanism responsible for the reuptake of NE and serotonin athe presynaptic nerve terminals, potentiating activity at the postsynaptic terminals. One of the more sedative of the tricyclic anti-depressants.
  28. Elavil
    dosage form?
    Tablets (10, 25, 50, 75, 100, 150 mg)
  29. Allegra
    generic?
    fexofenadine hydrochloride
  30. Allegra
    class?
    antiallergy agent
  31. Allegra
    MOA?
    a metabolite of terfenadine, antagonizes H1 (histamine) receptors in peripheral tissues. Less frequent drowsyness = does not penatrate BBB.
  32. Allegra
    dosage form?
    • Tablets (30, 60, 180 mg)
    • Tablets (orally disintegrating = Allegra ODT)
    • Oral suspension
  33. Coreg
    generic?
    carvedilol
  34. Coreg
    class?
    antihypertensive
  35. Coreg
    MOA?
    nonselective beta-adrenergic blocking agent with alpha-1-adrenergic blocking activity.
  36. Coreg
    dosage form?
    Tablets (regular, generic - immediate release)
  37. Coreg CR
    generica?
    carvedilol
  38. Coreg CR
    class?
    antihypertensive
  39. Coreg CR
    MOA?
    nonselective beta-adrenergic blocking agent with alpha-1-adrenergic blocking activity.
  40. Coreg CR
    dosage form?
    Capsules (10, 20, 40, 80 mg)
  41. Risperdal
    generic?
    risperidone
  42. Risperdal
    class?
    antipsychotic
  43. Risperdal
    MOA?
    unknown. Thought to act by direct antagonism of dopamine (D2) and serotonin (5HT2) receptors in the central nervous system. Also produces antagonism of alpha-1, alpha-2, and H-1 histaminergic receptors.
  44. Risperdal
    dosage form?
    • Tablets (regular, orally-disintegrating = Risperdal-M-Tab)
    • Oral solution
    • Powder for Injection (Risperdal Consta)
  45. Detrol
    generic?
    tolterodine tartrate
  46. Detrol
    class?
    urinary bladder modifier
  47. Detrol
    MOA?
    competitive muscarinic receptor antagonist. Its effects on the bladder include an increase in residual urine, reflecting an incomplete emptying of the bladder, and a decrease in detrusor pressure.
  48. Detrol
    dosage form?
    Tablets (1, 2 mg)
  49. Detrol LA
    generic?
    tolterodine tartrate
  50. Detrol LA
    class?
    urinary bladder modifier
  51. Detrol LA
    MOA?
    competitive muscarinic receptor antagonist. Its effects on the bladder include an increase in residual urine, reflecting an incomplete emptying of the bladder, and a decrease in detrusor pressure.
  52. Detrol LA
    dosage form?
    Capsules (extended)
  53. Vibramycin
    generic?
    doxycycline hyclate
  54. Vibramycin
    class?
    tetracycline antibiotic
  55. Vibramycin
    MOA?
    prevents bacterial protein synthesis by competitively binding to the 30S ribosomal subunit.
  56. Vibramycin
    dosage form?
    • Tablets (regular, delayed)
    • Capsules
    • Syrup
    • Powder for oral suspension
    • Powder for injection
  57. Doryx
    generic?
    doxycycline hyclate
  58. Doryx
    class?
    tetracycline antibiotic
  59. Doryx
    MOA?
    prevents bacterial protein synthesis by competitively binding to the 30S ribosomal subunit.
  60. Doryx
    dosage form?
    • Tablets (regular, delayed)
    • Capsule
    • Syrup
    • Powder for oral suspension
    • Powder for injection
  61. Protonix
    generic?
    pantoprazole sodium
  62. Protonix
    class?
    gastric antisecretory
  63. Protonix
    MOA?
    a proton pump inhibitor (PPI) that suppresses the final step in gastric acid production by forming a covalent bond to two sites of the (H+, K+)-ATPase enzyme system at the secretory surface of the gastric parietal cell.
  64. Protonix
    dosage form?
    • Tablets (delayed)
    • Granules for oral suspension
    • Powder for injection
  65. Lyrica
    generic?
    pregabalin
  66. Lyrica
    class?
    anticonvulsant/antineuralgic
  67. Lyrica
    MOA?
    mechanism may be related to its high binding affinity to the alpha(2)-delta site in CNS tissues. Structure similar to GABA, but not bind to GABA receptors nor alters GABA uptake or degradation. May increase the density of GABA transporter protein and increase the rate of functional GABA transport.
  68. Lyrica
    dosage form?
    • Capsules
    • Solution
  69. Adderall
    generic?
    amphetamine with dextromamphetamine salts
  70. Adderall
    class?
    CNS agent for ADHD
  71. Adderall
    MOA?
    For ADD is unknown. In adults, it causes CNS stimulation by a direct action on adrenergic receptors, releasing norepinephrine from storage sites.
  72. Adderall
    dosage form?
    Tablets
  73. Adderall XR
    generic?
    amphetamine with dextroamphetamine salts
  74. Adderall XR
    class?
    CNS agent for ADHD
  75. Adderall XR
    MOA?
    For ADD is unknown. In adults, it causes CNS stimulation by direct action on adrenergic receptors, releasing norepinephrine from storage sites.
  76. Adderall XR
    dosage form?
    Capsules (extended)
  77. Zofran
    generic?
    ondansetron hydrochloride
  78. Zofran
    class?
    antiemetic
  79. Zofran
    MOA?
    selective 5-HT3 receptor antagonist. These receptors found peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone of the area postrema. Primary MOA in cytotoxic chemotherapy is thought to be through an inhibition of serotonin receptors in the small intestine.
  80. Zofran
    dosage form?
    • Tablets (regular, orally-disintegrating = ODT)
    • Oral solution
    • injectable
  81. Prevacid
    generic?
    lansoprazole
  82. Prevacid
    class?
    gastric antisecretory
  83. Prevacid
    MOA?
    inhibits the H+/K+ ATPase enzyme system at the secretory surface of the gastric parietal cell. Gastric acid-pump inhibitor. Effect is dose-related and leads to both basal and stimulated gatric acid secretion irrespective of hte stimulus.
  84. Prevacid
    dosage form?
    • Tablest (orally-disintegrating = SoluTab)
    • Capsules (delayed)
  85. Percocet
    generic?
    oxycodone (hydrochloride) with acetaminophen
  86. Percocet
    class?
    opioid analgesic
  87. Percocet
    MOA?
    • acetaminophen - inhibiting prostaglandin synthesis in the CNS and through a peripheral action by blocking pain impulse generation
    • oxycodone - centrally via action on the central opiate receptors
  88. Percocet
    dosage form?
    Tablets
  89. Roxicet
    generic?
    oxycodone (hydrochloride) with acetaminophen
  90. Roxicet
    class?
    opioid analgesic
  91. Roxicet
    MOA?
    • acetaminophen - inhibiting prostaglandin synthesis in the CNS and through a peripheral action by blocking pain impulse generation
    • oxycodone - centrally via action on the central opiate receptors
  92. Roxicet
    dosage form?
    Tablets
  93. Endocet
    generic?
    oxycodone (hydrochloride) with acetaminophen
  94. Endocet
    class?
    opioid analgesic
  95. Endocet
    MOA?
    • acetaminophen - inhibiting prostaglandin synthesis in the CNS and through a peripheral action by blocking pain impulse generation
    • oxycodone - centrally via action on the central opiate receptors
  96. Endocet
    dosage form?
    Tablets
  97. Tenormin
    generic?
    atenolol
  98. Tenormin
    class?
    antihypertensive
  99. Tenormin
    MOA?
    relatively cardioselective beta-1-adrenergic receptor blocker which results in: (1) decreased heart rate and cardiac output, (2) decrease in systolic and diastolic blood pressure, (3) inhibition of isoproterenol tachycardia. Does not cross BBB.
  100. Tenormin
    dosage form?
    Tablets (25, 50, 100 mg)
  101. Nasonex
    generic?
    mometasone furoate monohydrate (intranasal)
  102. Nasonex
    class?
    antiallergy agent
  103. Nasonex
    MOA?
    forms steroid-receptor complex that stimulate or inhibit the transcription of m-RNA. Stimulation results in synthesis of specific enzymes that caryy out its antiallergy and anit-inflammatory actions.
  104. Nasonex
    dosage form?
    Nasal spray
  105. Depakote
    generic?
    divalproex sodium
  106. Depakote
    class?
    anticonvulsant/antipsychotic
  107. Depakote
    MOA?
    dissociates into valproate in the GI tract. MOA is unkown although it is thought to be related to increased brain levels of GABA, possibly due to an inhibition of GABA transaminase or succinic semialdehyde dehydrogenase or by inhibition of reuptake by glial cells and nerve endings.
  108. Depakote
    dosage form?
    • Tablets (enteric coated)
    • Sprinkle capsules coated particles)
  109. Depakote ER
    generic?
    divalproex sodium
  110. Depakote ER
    class?
    anticonvulsant/antipsychotic
  111. Depakote ER
    MOA?
    dissociates into valproate in the GI tract. MOA is unknown although it is thought to be related to increased brain levels of GABA, possibly due to inhibition of GABA transaminase or succinic semialdehyde dehydrogenase or by inhibition of reuptake by glial cells and nerve endings.
  112. Depakote ER
    dosage form?
    • Tablets (extended)
    • Sprinkle capsules
  113. Lopressor
    generic?
    metoprolol tartrate
  114. Lopressor
    class?
    antihypertensive
  115. Lopressor
    MOA?
    a relatively cardioselective beta-1 adrenergic receptor blocker which: (1) decreases heart rate and cardiac output; (2) decreases systolic and diastolic blood pressure; (3) inhibits isoproterenol tachycardia; (4) decreases reflex orthostatic tachycardia. Croses BBB.
  116. Lopressor
    dosage form?
    • Tablets (25, 50, 100 mg)
    • Injection (5 mg/5 mL)

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