What drugs or food have the potential to interact with the NSAIDs (COX-1 and COX-2 inhibitors) aspirin/acetylsalicylic acid (Aspirin) and ibuprofen (Advil, Motrin)?
- Anticoagulants, glucocorticoids, and alcohol increase the risk of bleeding.
- Ibuprofen decreases the antiplatelet effects of low-dose aspirin.
- Angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers increase the risk of renal failure.
- ACE inhibitors decrease.
- The risk of lithium carbonate (Eskalith) and methotrexate (Rheumatrex) toxicity increases.