Pharmacology

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Author:
amgomez
ID:
107212
Filename:
Pharmacology
Updated:
2011-10-08 01:18:30
Tags:
Pain Inflammation Drugs Interactions
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Description:
Food and Drug Interactions
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  1. What drugs or food have the potential to interact with the centrally acting nonopioid drug tramadol (Ultram)?
    • Monoamine oxidase inhibitors (MAOIs) pose a risk for hypertensive crisis.
    • Selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, tricyclic antidepressants, MAOIs, and triptans pose a risk for serotonin syndrome.
    • Responses to CNS depressants increase.
    • Carbamazepine (Tegretol) decreases levels.
    • St. John's wort increases sedative effects.
  2. What drugs or food have the potential to interact with the glucocorticoid drug prednisone (Deltasone)?
    • Potassium-depleting diuretics, such as furosemide (Lasix), increase the risk of hypokalemia.
    • The risk of digoxin-induced dysrhythmias increases with digoxin.
    • NSAIDs increase the risk of gastrointestinal bleeding and ulceration.
    • Effects of insulin and oral hypoglycemics decrease in a patient who has diabetes mellitus.
    • Prednisone prevents the body from responding to vaccines.
    • Live vaccine administration increases risk for developing that viral disease
  3. What drugs or food have the potential to interact with the uricosuric drug allopurinol (Zyloprim)?
    • Warfarin (Coumadin) requires lower dosages.
    • The risk of mercaptopurine (Purinethol), theophylline (Theolair), and azathioprine (Imuran) toxicity increases.
    • Ampicillin (Principen) increases the risk for rash.
  4. What drugs or food have the potential to interact with the NSAID (COX-2 inhibitor) celecoxib (Celebrex)?
    • Diuretic effects of furosemide (Lasix) decrease.
    • Fluconazole (Diflucan) increases celecoxib levels.
    • Anticoagulant effects of warfarin (Coumadin) increase.
    • Glucocorticoids and alcohol increase the risk of bleeding.
    • Antihypertensive effects of angiotensin-converting enzyme (ACE) inhibitors decrease.
    • The risk of lithium carbonate (Eskalith) toxicity increases.
  5. What drugs or food have the potential to interact with the opioid agonist drugs morphine and meperidine (Demerol)?
    • CNS depressants (barbiturates, phenobarbital, benzodiazepines, alcohol) increase CNS depression.
    • Anticholinergic agents, such as antihistamines, and tricyclic antidepressants increase anticholinergic effects (constipation, urinary retention).
    • MAOIs can cause hyperpyrexic coma (excitation, seizures, respiratory depression) with meperidine (Demerol).
    • Antihypertensives increase hypotensive effects.
    • St. John's wort may increase sedation.
  6. What drugs or food have the potential to interact with the drug acetaminophen (Tylenol)?
    • Alcohol increases the risk of liver injury (with high doses of acetaminophen).
    • Warfarin (Coumadin) increases the risk of bleeding.
    • Cholestyramine (Questran) reduces absorption.
  7. What drugs or food have the potential to interact with the opioid antagonist drug naloxone (Narcan)?
    Opioid effects decrease.
  8. What drugs or food have the potential to interact with the NSAIDs (COX-1 and COX-2 inhibitors) aspirin/acetylsalicylic acid (Aspirin) and ibuprofen (Advil, Motrin)?
    • Anticoagulants, glucocorticoids, and alcohol increase the risk of bleeding.
    • Ibuprofen decreases the antiplatelet effects of low-dose aspirin.
    • Angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers increase the risk of renal failure.
    • ACE inhibitors decrease.
    • The risk of lithium carbonate (Eskalith) and methotrexate (Rheumatrex) toxicity increases.
  9. What drugs or food have the potential to interact with the opioid agonist-antagonist drugs butorphanol (Stadol) and pentazocine (Talwin)?
    • Central nervous system (CNS) depressants (barbiturates, phenobarbital, benzodiazepines, alcohol) increase CNS depression and increase the risk of respiratory depression.
    • Opioid effects decrease.

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