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What might be the first presenting sign of a defect in primary hemostasis?
- Defect in BV's or PLT
- (Thrombocytopenia or Thrombocytopathy)
What might be the first presenting sign of a defect in secondary hemostasis?
- Meleana (dark, tarry feces)
- Haematemesis (Bloody vomit)
- Epitaxis Hemoptysis
- 1+ Hemotoma in tissues, cavities, joints
- Tissue Activating Factor
- VW Factor
What tests analyze Intrinsic & Common Pathways?
- Acitvated Partial Thromboplastin Time (aPTT)
- Partial Thromboplastin Time (PTT)
- Activated Clotting (ACT) (DEC SENS)
What tests analyze Extrinsic & Common Pathways?
One Stage Prothombin Time (OSPT)
What tests analyze Platelet/Vascular Problems?
- PLT count
- Clot Retraction Time
What test is indicative of excess FDPs?
What test most accurately tests Intrinsic & Commmon Pathways?
What test is used to SCREEN for Intrinsic/Common Deficiencies?
- Increased Bleeding time
- Increased Clot Refraction Time
- Increased Clot Lysis
What is indicative of PLT regeneration?
What can lead to Decreased Fibrinogen
- Liver Dz
- Heparin Toxicosis
How are FBP's formed?
- 1. Plasminogen =>Plasmin
- 2. --> fibrin => FDPs
Which test is dependent on prothombin and its converstion to thrombin?
Which 2 tests are performed together?
WVD, Warfarin toxicosis & Severe Liver Failure would => Increased...
Hemophilia, Heparin Toxicosis & Angiostrongylosis would => Increased...
Which test uses several Cap. Tubes?
- Coag Time
- (Dog/cat/pig=5-10m, bov=5-15m, Equ=20-30m)
Which test uses Siliceous Earth
Activated Coag Time
Which Test analyzes clotting time of citrated plasma Ca & +Thromboplastin
What test measures the size of serum that forms around blood clot after 1 hour?
CRT (Clot Retraction Time)
What is a crude test for PLT function?
Clot Retraction Time (CRT)
What conditions => thrombocytopenias due to destruction?
- Immune (destruction in BM)
- Neoplasia (MPD, LPD, Myelopthesis)
- Drugs (Phenylbut, cyclophosphomide & Estrogen)
- Cyclic Dyshemopoiesis
- Infections (erlichia, FeLV)
What conditions => thrombocytopenias?