351 Antimanic drugs

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351 Antimanic drugs
2011-10-08 16:02:21
351 Antimanic drugs

351 Antimanic drugs
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  1. What is lithium?
    • -Treats bipolar disorder
    • -competes with Sodium
    • -Maintenance dose is 900-1200
    • -Therapeutic drug levels: 0.6-1.2
    • SE: Dose dependent, hand tremot, metallic taste, Nephrogenic diabetes insipidus
    • -Contraindicated in pregnancy, renal and cardio issues
    • -Interactions: diurectics, hypertension, NSAIDS, low sodium, decreases with caffeine alcohol.
  2. When should a nurse check blood levels of lithium?
    -In the morning before first dose
  3. What are Valproates?
    • -Anticonvulsants
    • -Divalproex (Depakote)
    • -Increase inhibitory role of GABA, suppression of sodium and calcium influx
    • -Rapid onset
    • SE: transient hair loss, weight gain, tremores, GI upset, and dose related thrombocytopenia
    • -Therapetuic serum levels are from 50-115 mcg/ml
    • -Teratogenicity
  4. What is carbamazepine (Tegretol)?
    • -Anticonvulsant
    • -Good for rapid cycling bipolar
    • -Therapeutic level: 4-12 mcg/ml
    • SE: nausea, anorexia, and occasional vomiting, sedation, drowsiness, agranulocytosis
    • -Do not give with SSRIs
  5. What is Lamotrigine (Lamictal)?
    • -Anticonvulsant
    • -Treats bipolar disorder and bipolar depression
    • -Manipulates GABA system and glutamate
    • -Stevens-Johnson syndrome is a serious potentially fatal skin rush
  6. What is Oxcarbazepine (Trileptal)?
    • -Anticonvulsant
    • -Drug does not cause some of the more serious adverse reactions
  7. What is Gabapentin (Neurontin)?
    • -Anticonvulsant
    • -Adjunctive agent
    • -Similar to lamotrigine
  8. What is topiramate (topamax)?
    • -Anticonvulsant
    • -Increases GABA, blocks voltage gated sodium and calcium and inhibits glutamute. -Many patients reprot weight loss with this drug
  9. Which atypical antipsychotic is not effective for treating mania?