341 - Analgesic Drugs

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Author:
estee08
ID:
107684
Filename:
341 - Analgesic Drugs
Updated:
2011-10-10 00:07:34
Tags:
pharmacy
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Description:
PHAR 341 Analgesic Drugs
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  1. Tetrodotoxin
    • Natural Toxin: Site 1 Sodium Channel Blocker
    • It binds to a specific receptor on the outside of the sodium channel and prevents sodium influx
    • Found in fugu and death occurs to paralysis of the diaphragm and drop in blood pressure
  2. Saxitoxin
    • Natural Toxin: Site 1 Sodium Channel Blocker
    • It binds to a specific receptor on the outside of the sodium channel and prevents sodium influx
    • Found in shellfish and death occurs to paralysis of the diaphragm and drop in blood pressure
  3. Procaine
    • Ester Local Anesthetic
    • Administration: Infiltration (dental)
    • Very low lipid solubility - very low duration
    • Low toxicity
    • pKa ~ 8
  4. Tetracaine
    • Ester Local Anesthetic
    • Administration: Infiltration (dental)
    • High lipid solubility - very long duration
    • pKa ~ 8
  5. Benzocaine
    • Ester Local Anesthetic
    • Administration: Topical (skin, mucous membranes)
    • Moderate lipid solubility - Lasts only while in contact
    • pKa ~ 2.5 - will always be in base form at pH=7.4
  6. Cocaine
    • Ester Local Anesthetic
    • Administration: Topical (eyes)
    • High lipid solubility
    • High toxicity
    • pKa ~ 8
  7. Lidocaine
    • Amide Local Anesthetic
    • Administration: All routes (topical, infiltration, epidural, caudal, spinal)
    • Moderate lipid solubility - moderate Duration
    • Moderate toxicity
    • pKa ~ 8
  8. Mepivacaine
    • Amide Local Anesthetic
    • Administration: Infiltration, nerve block
    • Low lipid solubility - long duration
    • Moderate toxicity
    • pKa ~ 8
  9. Bupivacaine
    • Amide Local Anesthetic
    • Administration: All routes
    • High lipid solubility - very long duration
    • High toxicity (cardiotoxic)
    • pKa ~ 8
  10. Ropivacaine
    • Amide Local Anesthetic
    • Administration: Nerve block, epidural, caudal
    • High lipid solubility - very long duration
    • Moderate toxicity (less cardiotoxic than bupivacaine)
    • pKa ~ 8

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