341 - Anti-nicotinic Drugs

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Author:
estee08
ID:
107922
Filename:
341 - Anti-nicotinic Drugs
Updated:
2011-10-10 21:45:56
Tags:
pharmacy
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Description:
PHAR 341 - Ganglion Blockers (Anti-nicotinic drugs)
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  1. Note
    Look at all the effects (second page) and side effects (last page) of ganglion blockers in the notes, all the drugs in this section have these effects.
  2. Trimethapan
    • Competitve antagonist of neuronal nicotinic receptor
    • Used iv
    • Rapid onset of action, but it shows tachyphylaxis (progressive decrease of effectiveness with continual use)
    • Malignant Hypertension: severe syndrome characterizied by a very high diastolic BP
    • Postoperative Hypertension: less severe syndrome characterized by a high systolic and diastolic BP.
  3. Tubocurarine
    • Competitive antagonist
    • Blocks mostly muscle nictonic receptor (leads to skeletal muscle relaxation) and has modest ganglion nicotinic blocking activity
  4. Mecamylamine
    • Non-competitive ganglion nicotinic blocker
    • Open channel block of the nictonic receptor (can't be overcome by increasing ACh)
    • Crosses blood-brain barrier
    • Hypertension Treatment: drug causes bothersome side effects at therapeutic doses
  5. Hemicholinium
    • Non-competitive ganglion nicotinic blocker
    • Open channel block of the nictonic receptor (can't be overcome by increasing ACh)

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