ADT Exam 1

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Advantages of Nasal drug delivery
- fast absorption and rapid onset
- avoids first pass
- easy administration
- controlled drug delivery
Systemic drugs must be delivered to

mid and upper turbinates
Three barriers to nasal absorption
- physical barrier: mucus and epithelium
- temporal barrier: mucociliary clearance
- Enzymatic barrier: drug degradation
zona occludens

restricts movement of large particles between cells
Nasal absorption decreases with

increased ionization
Optimal absorption of lipophilic drugs

above 300 buffered partition coefficient
Drug absorption decreases as particle size/molecular weight

increases
Strategies to enhance nasal drug delivery
- co administration with an enzyme inhibitor
- bioadhesive systems
- prodrugs