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ADT Exam 1
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Advantages of Nasal drug delivery
fast absorption and rapid onset
avoids first pass
easy administration
controlled drug delivery
Systemic drugs must be delivered to
mid and upper turbinates
Three barriers to nasal absorption
physical barrier
: mucus and epithelium
temporal barrier
: mucociliary clearance
Enzymatic barrier
: drug degradation
zona occludens
restricts movement of large particles between cells
Nasal absorption decreases with
increased ionization
Optimal absorption of lipophilic drugs
above 300 buffered partition coefficient
Drug absorption decreases as particle size/molecular weight
increases
Strategies to enhance nasal drug delivery
co administration with an enzyme inhibitor
bioadhesive systems
prodrugs
Author
Rx2013
ID
107923
Card Set
ADT Exam 1
Description
Nasal Drug Delivery
Updated
10/11/2011, 1:46:04 AM
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