ADT Exam 1

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Author:
Rx2013
ID:
107950
Filename:
ADT Exam 1
Updated:
2011-10-10 22:35:25
Tags:
MRP
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Description:
MRP
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  1. Multi-drug resistance phenotype in tumors is associated with
    over expression of certain ABC transporters (MDR proteins)
  2. MDR1 Structure
    • amino and carboxy terminal are intracellular
    • 12 trans membrane
    • 2 ABC binding domains
  3. MRP1 structure
    • 17 transmembrane
    • amino terminus is extracellular
    • carboxy terminus is intracellular
    • 2 ABC binding domains
  4. ABCG2 (MXR/BCRP) receptor
    • Amino and carboxy terminus are intracelluar
    • 6 transmembrane
  5. Efflux transporters located on the basolateral side of the intestine
    • MRP 1, 3, 4, 5 & 6
    • efflux drugs from cells to blood
  6. Efflux transporters located on the apical side of the intestinal lumen
    • BCRP
    • MDR1
    • MRP2
    • MRP4
    • push drugs back into the intestines
  7. PGP mediated drug efflux
    activation of efflux pump by hydrolysis of ATP drives cytotoxic molecules out of the cell
  8. can be used to inhibit PGP and increase doxorubicin
    PSC 833
  9. CYP3A4 inducers
    • carbamazepine
    • rifampin
    • ritonavir
    • st. john's wort
  10. CYP3A4 inhibitors
    Ritonavir
  11. Tipranavir/ritonavir
    statsistically superior to CPI/ritonivir
  12. efavirenz and nevirapine ____ kaletra levels
    decrease
  13. rescro[tpr (de;avordome) will ____ kaletra levels
    increase
  14. St. John's wort ____ serum concentrations of many drugs by ___.
    • decreases
    • induces PGP and CYP3A4
  15. SJW and narcotic induced sleeping time
    increased
  16. SJW and reserpine
    SJW antagonizes effects
  17. Herbal constituents will exhibit _____ of PGP and cyp initially then ___.
    • inhibition
    • induction

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