drugs

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Anonymous
ID:
108004
Filename:
drugs
Updated:
2011-10-11 03:09:01
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anti pathogens
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Description:
anti viral, anti microbial
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  1. Amantadine
    Influenza A tx|Inhibits viral uncoating
  2. Oseltamivir (Tamiflu)
    Influenza tx|Oral nuraminidase inhibitor (sialic acid analog, inhibits virion release)
  3. Zanamivir
    Influenza tx|Inhaled nuraminidase inhibitor (sialic acid analog)
  4. Acyclovir
    Herpesvirus tx|Nucleoside analog
  5. Valacyclovir
    Herpesvirus tx|Acyclovir prodrug (nucleoside analog for viral thymidine kinase)
  6. Famciclovir
    Herpesvirus tx|Penciclovir prodrug (nucleoside analog)
  7. Ganciclovir
    Herpesvirus, CMV tx|IV nucleoside analog for viral thymidine kinase
  8. Valganciclovir
    Herpesvirus, CMV tx|Oral, ganciclovir prodrug (nucleoside analog for viral thymidine kinase)
  9. Ribavirin
    Hep C, RSV tx, experimental RNA virus tx|Sythetic guanosine analogue (interferes w/ txn)
  10. Penicillin G
    Strep, Syphilis, Spirochete tx|Natural penicillin, highly susceptible to Beta lactams
  11. Penicillin V
    Strep, Syphilis, Spirochete tx (gram +)|Natural penicillin, highly susceptible to Beta lactams
  12. Ampicillin
    Enhanced gram (-) coverage, listeria/H. influenzae tx
  13. Ampicillin/Sulbactam
    GI & resp tract gram (-) tx|IV formulation
  14. Amoxicillin
    Enhanced gram (-) coverage, Group A strep tx
  15. Amoxicillin/Clavulanate
    Active against most respiratory and some GI gram (-), staph|PO
  16. Methicillin
    Gram (+) tx|More stable to Beta-lactamases (IV)
  17. Oxicillin
    Gram (+) tx|More stable to Beta-lactamases (IV)
  18. Dicloxacillin
    Gram (+) tx|More stable to Beta-lactamases (PO)
  19. Piperacillin
    Enhanced gram (-) coverage|(IV)
  20. Piperacillin/Tazobactam
    GI & resp tract gram (-), pesudomonas aeruginosa tx|(IV)
  21. Imipenem
    Very broad specturm (MSSA, pseudomonas, anaerobics)|Seizure risk
  22. Ertapenem
    Broad spectrum, no pseudomonas activity|(IV qd)
  23. Cefazolin
    Good gram (+), limited gram (-), MRSA tx|(IV)
  24. Cephalexin
    Good gram (+), limited gram (-), MRSA tx|(PO)
  25. Cefuroxime
    Good gram (+), moderate gram (-), CA-pneumococcus/H. influenzae tx|(PO)
  26. Cefoxitin
    Good gram (+), moderate gram (-), some anaerobic |(IV)
  27. Ceftriaxone
    S. aureus, gonorrhea, gram (-) tx|(IV/IM)
  28. Ceftazidime
    No gram (+), Pseudomonas tx|(IV)
  29. Cefixime
    Gonorrhea, tonsilitis, pharyngitis tx|(PO)
  30. Cefdinir
    Broad-spectrum, good-tasting (used for peds)
  31. Cefepime
    Very good gram (+), S. aureus, good gram (-), P. aeruginosa tx|(IV)
  32. Trimethoprim/ Sulfamethoxazole
    Gram (+) & gram (-) tx|Trimethoprim inhibits bacteria dyhydrofolate reductase|Sulfonamides inhibits PABA & pteridine
  33. Vancomycin
    Broad activity vs gram (+), 1st line tx vs MRSA|Interrupts cell wall crosslinking|Tox: Red Man Syndrome
  34. Tetracycline
    Very broad spectrum (STD, pneumonia, malaria prophylaxis)|Bind to 30s subunit to inhibit tRNA binding to A site|Not used in children (stains teeth)
  35. Doxycycline
    Broad spectrum, good Gm (-)|Billiary excretion
  36. Gentamicin
    Aerobic gram (-) tx, some staph/strep|Disrupts electrochem gradient (aerobic only)
  37. Tobramycin
    Aerobic gram (-) tx, some staph/strep|Disrupts electrochem gradient (aerobic only)
  38. Amikacin
    Aerobic gram (-) tx, some staph/strep|Disrupts electrochem gradient (aerobic only)
  39. Erythromycin
    Active vs chlamydia, rickettsia, mycoplasma, legionella gram (+)|Bacteriostatic (bind 50s subunit)|More GI upset, more freq dosing, lesser spectrum than other macrolides, (IV & PO)
  40. Clarithromycin
    Active vs chlamydia, rickettsia, gram (+), highly active vs mycoplasma,|Bacteriostatic (bind 50s subunit)|Only PO
  41. Azithromycin
    Active vs chlamydia, rickettsia, gram (+), highly active vs mycoplasma|Bacteriostatic (bind 50s subunit)|Longer t1/2, no hepatic metabolism, compared to other macrolides, (IV & PO)
  42. Clindamycin
    Active vs gram (+), staph, & anaerobes|Protein synth inhibitor
  43. Linezolid
    S. aureus/MRSA, strep, enerococcus faecium/faecalis,VRE tx|Protein synth inhibitor|Weak MAOI -> serotonin syndrome w/SSRIs
  44. Daptomycin
    Active against many gram (+), MRSA, VRE |Not for pneumonia (inactivated by surfactant)|Inserts K+ channel into gram (+) & disrupts electrochem gradient
  45. Rifampin
    Active vs gram (+), mycobacteria|Inhibits mRNA synth|(PO, IV)
  46. Metronidazole
    Highly bactericidal for anaerobic bact (no activity vs gm +/-, aerobic), protozoan tx|e- acceptor that damages DNA
  47. Ciprofloxacin
    Gram (-), Pseudomonas, GI/UTI infection tx|Interacts with DNA gyrase|(IV,PO)
  48. Levofloxacin
    Active vs gram (+), gram (-) |Pure S isomer of ofloxacin|Interacts w/ DNA gyrase, topoisomerase|(IV, PO)
  49. Nitrofurantoin
    Used only for UTIs (only active in bladder)
  50. Isoniazid
    TB tx|Hepatotoxicity risk in slow acetylators
  51. Pyrazinamide
    TB, TB meningitis tx|Part of multidrug tx
  52. Ethambutol
    Bacteriostatic anti-TB drug|Part of multidrug tx
  53. Amphotericin B
    Most broad-spectrum anti-fungal|Forms channel in fungal membrane -> loss of cations|Nephortoxicity w/ >2wks use, lipid formulation much safer
  54. Nystatin
    Topical polyene antifungal (disrupts cell wall)|Too nephrotoxic for systemic use
  55. Fuconazole
    Active vs most cryptococcus, candida|14 alph-demethylase inhibitor -> prevents ergosterol synth
  56. Voriconazole
    Candida, invasive aspergillosis tx|14 alph-demethylase inhibitor -> prevents ergosterol synth|(PO & IV)
  57. Posaconazole
    Active vs most candida, most aspergillus, many molds|PO only
  58. Caspofungin
    2nd line aspergillus tx|Beta 1,3 D glucan synth inhibitor -> interferes with cell wall synth|(IV)
  59. Terbinafine
    Onychomycosis, tinea tx, adjunctive for severe mold|Inhibits squalene epoxidase step in ergosterol biosynth
  60. Chloroquine
    Malaria tx|Inhibits polymerization of hemozoin in plasmodium food vacuole|PO
  61. Mefloquine
    Later-gen quinacrine malaria tx|Weekly dosing
  62. Atovaquone/Proguanil (Malarone)
    Anti-malarial|Inhibits mitochondial ETC/DHFR
  63. Artemisinin
    Anti-malarial
  64. Albendazole
    Anti-helminthic tx|Inhibits tubuline polymerization/MT formation in worms
  65. Mebendazole
    Anti-helminthic tx|Inhibits tubuline polymerization/MT formation in worms
  66. Praziquantel
    Scistsomiasis, clonorchiasis, & other fluke tx
  67. Cyclophosphamide
    Nitrogen mustard alkylating agent -> cross links DNA|Toxicity: Hemorrhagic cystitis
  68. Cisplatin
    Platinum-containing anti-cancer agent |Toxicity: Neuropathy, hearing loss, kidney damage, emetogenic
  69. Carboplatin
    Platinum-containing anti-cancer agent|Toxicity: neuropathy
  70. Vincristine
    Plant alkyloid used for ALL, Hodgkins, NHL|Severe toxicity to lymphoid cells (blocks MTs)
  71. Vinblastine
    Plant alkyloid used for ALL, Hodgkins, NHL|Severe toxicity to lymphoid cells (blocks MTs)
  72. Methotrexate
    Dihydrofolate reductase inhibitor (anti-folate)|Leucovorin antidote rescues non-cancer marrow cells
  73. 5-fluorouracil
    Thymidylate synthase inhibitor used for GI malignancy
  74. Tamoxifen
    Breast cancer tx|Binds estrogen receptor
  75. Anthracyclines
    Antineoplastic antibiotic from Streptomyces|Intercalate between DNA strands, chelation, topoisomerase inhibition|Toxicity: cardio, alopecia, myelosuppression
  76. Imantinib
    CML tx|Bcr-abl tyrosine kinase inhibitor
  77. All-trans retinoic acid (ATRA)
    APL tx|Induces differentiation
  78. Rituximab
    Anti-CD20 chimeric Ab (anti-Bcell) used for leukemia/lymphoma
  79. Warfarin (Coumadin)
    Anticoagulant |Vitamin K antagonist
  80. Heparin
    Anticoagulant|Inactivates thrombin & Fxa

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