Unit 7 Pharmacokinetics

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harstanner
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108312
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Unit 7 Pharmacokinetics
Updated:
2011-10-13 00:46:10
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Unit Pharmacokinetics
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Unit 7 Pharmacokinetics
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  1. study of what the body does to the drug molecules (or the effect of the body on the drug)
    Pharmacokinetics
  2. •Involves
    –1. Absorption
    –2. Distribution
    –3. Metabolism
    –4. Excretion
    Pharmacokinetics
  3. process by which a drug is transferred from its site of entry into the body to the bloodstream
    Absorption
  4. Route of administration (IV faster than oral)
    Factors that affect absorption
  5. Lipid solubility (Lipid soluble drug absorbed faster)
    Factors that affect absorption
  6. pH (Acidic drugs absorbed in stomach)
    Factors that affect absorption
  7. Blood flow (Absorption decreased with impaired circulation)
    Factors that affect absorption
  8. Local conditions at site (IM injection/burn)
    Factors that affect absorption
  9. movement of drug by the circulatory system to the site of action
    Distribution
  10. Factors that affect _________;
    –Blood flow to tissues
    –Drug’s ability to leave bloodstream
    –Drug’s ability to enter cells
    Distribution
  11. break down of a drug into a different form
    Metabolism
  12. Liver is primary site for
    Metabolism
  13. Other sites: kidney, lungs, etc.
    Metabolism
  14. Decreased function of metabolic organs =
    decreased metabolism of drug
  15. after drug is broken down and metabolized, the metabolites need to be removed from the body
    Excretion
  16. Kidneys _______ most drugs
    excrete
  17. Other sites: lungs, bile/feces, sweat, salivary, and mammary glands
    Excretion

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