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The flashcards below were created by user
kepling
on FreezingBlue Flashcards.
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Why is a beta blocker important during exercise?
Will keep HR and BP in check for someone who might be HTN
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Name the three main effects of alpha blockade in general?
- Decreased PR, hypotension
- Reflex tachycardia (due to reduced BP, inc NE, B rec activation)
- Decreased vagal input
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Three signs of Pheochromocytoma?
- Arrhythmias
- Tachycardia
- HTN
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What metabolite is measured to ID pheochromocytoma?
- 24-hr uring NE and VMA
- **TOO high VMA = tumor present
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principal drug used for Pheochromocytoma?
Phenoxybenzamine
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What happens to half life of Prazosin with CHF? Dosage?
- half-life: doubles
- dosage: cut in half
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What drug is an alpha 2 blocker and antagonizes Clonidine?
Yohimbine
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Effects of Beta blockers and Epinephrine on phase 4 depolarization?
- beta blockers: decrease rate of phase 4 depolarization
- Epi: increase rate of phase 4 depolarization
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Epi effects on BP w/ Beta blockers? How to overcome?
- BP shoots up b/c of effect on alpha receptors
- ** Overcome with tag teaming alpha blocker
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Which is better for a diabetic: Beta 1 or 2 blocker? Why?
Beta 1 b/c Beta 2 blockers inhibit gluconeogenesis and glycogenolysis
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Effect of K uptake into cells when Beta blockers are used?
K uptake is inhibited
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VLDL & HDL effect from Beta blockers? Why?
- VLDL increase, HDL decrease
- ** b/c B3 generally helps with lipolysis of FFA, but since it is shut off the FFA circulate
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What five beta blockers have anesthetic affects?
- Acebutolol & Pindolol (intrinsic sym. activity)
- Propranolol (B-rec blocker)
- Metoprolol (B1 blocker)
- Labetolol (Alpha & Beta blocker)
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cimetidine effect on Propranolol?
Cimetidine inhibits CYP2D6 metabolism of Propranolol = extended effects
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Effect of barbituates, phenytoin, rifampin & smoking on propranolol?
increased metabolism of Propranolol through CYP2D6 system
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Ca channel effect if tagged with Propranolol?
Horrible bradycardia and HypoTN
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Which Beta blocker causes the worst fatigue?
Propranolol
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Problem with using Verapamil + Beta blocker?
Verapamil = Ca channel blocker, so if you are all ready causing braycardia it will become worse
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What drug type should you use if there is a lot of Epi present?
Alpha and Beta blocker
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