Induction Agents

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  1. Barbiturate MOA?
    Depress the reticular activating system (a polysynaptic network of neurons & regulatory centers) located in the brainstem that controls vital functions, including consciousness. In clinical doses – they affect the function of nerve synapses rather than axons

    They suppress the transmission of excitatory neurotransmitters (ACh) & enhance transmission of inhibitory neurotransmitters (GABA) by interfering with transmitter release (presynaptic) and selectively interacting with receptors (postsynaptic)
  2. Oxybarbiturate structure? Examples?
    Structure: O2 on #2 Carbon atom

    Examples: phenobarbital, pentobarbital, secobarbital, methohexital
  3. Thiobarbiturate structure? Examples?
    Structure: sulfur on #2 Carbon atom

    Examples: thiopental, thiamylal
  4. Sodium Thiopental properties
    • onset = 30 seconds (high lipid solubility)
    • dose = 3 - 6mg/kg for induction
    • rapid awakening d/t redistribution
    • highly protein bound (up to 86%)
    • great affinity for fat (can lead to accumulation with large/repeated doses) --> doses should be calculated on IBW

Card Set Information

Author:
Anonymous
ID:
108652
Filename:
Induction Agents
Updated:
2011-10-13 10:42:48
Tags:
induction
Folders:

Description:
anesthesia
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