Path fall midterm GI one

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    Mallory-Weiss tears

    from severe retching/vomiting

    GI bleed and hematemesis

    Rarely perforation
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    Candida infection of esophagus
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    HSV inclusions

    "eggs in a basket"

    infects esophagus, gu in immunocompromised people.
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    CMV inclusion in esophageal infection
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    Hyperplasia of basal cells, mixed inflam cells, few eosinophils

    Dx endoscopically
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    Eosinophilic esophagitis

    more in males

    dysphagia or food impaction (food sticks to esoph)
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    Eosinophilic Esophagitis

    Trachealization of esophagus
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    Barret's esophagus

    Glandular tissue creeps up esophagus

    Increased risk of cancer
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    Barrett's esophagus

    bottom left is normal. top is dysplastic. hyperchromatic, stratified nuclei, little mucous production
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    Barrett's esophagus

    High grade dysplagia
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    Adenocarcinoma of the Esophagus (distal)

    M>F, caucasians>others
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    Esophageal adenocarcinoma

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    Esophageal squamous cell carcinoma

    • Very common world-wide
    • M>F
    • Inc risk with EtOH, tobacco, achalasia
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    Esophageal squamous cell carcinoma

    • No glands
    • Basal, dark cell. Sometimes keratin forms.
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    Normal fundic stomach

    V Pink parietal cells. Mucus cells
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    Normal antrum stomach

    Lots of mucin glands
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    Helicobacterial gastritis

    Curvilinear gram neg bacteria producing urease and toxin (CagA)
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    H. Pylori gastritis

    Inflammatory cell infiltration
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    Autoimmune gastritis

    Autoantibodies against parietal cells or intrinsic factor

    Causes hypochlorhydria and anemia
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    Gastric polyp
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    Gastric Polyp
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    Gastric Polyp. Fundic gland polyp.
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    Gastric adenoma. (Polyp)
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    Localized/intestinal Gastric Carcinoma
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    Diffuse infiltrating gastric carcinoma. More dangerous.
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    Intestinal type Gastric Carcinoma.

    Gland formation
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    Diffuse infiltrating gastric carcinoma

    Very differentiated. Signet ring cells all same, secrete mucin
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    Intestinal lymphoma with serosal nodules
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    GI lymphomas

    Diffuse thickening of small bowel
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    GI lymphoma

    Gastric MALT lymphoma. Invastion of glands
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    GI carcinoid tumor

    Ball like nests.

    • Look like carcinoma but less predictable behavior.
    • Neuroendocrine cell tumor.
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    GI carcinoid tumor

    Neuroendocine secreting tumor

    monomorphic cells. glands don't secrete into duct, straight to blood. Membrane bound granules.
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    Gastrointestinal stromal tumor

    connective tissue mesenchyme tissue
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    Fleshy, firm tumor. Just bulges, no penetration.
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    Stains for C-kit or CD117
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    Celiac disease

    Small intestine with villus atrophy. lots of lymphocyte infiltration.
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    Diffuse eosinophilic infiltrates in parasitic infection. (Ascaris and Strongyloides)
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    Schistosomiasis parasitic infection
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    Entamoeba histolytica parasitic infection
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    • Giardia lamblia
    • Parasitic enterocolitis
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    Cryptosporidia parasitic infection
Card Set
Path fall midterm GI one
gi neoplasia
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